Pulmonary deposition of salbutamol aerosol delivered by metered dose inhaler, jet nebulizer, and ultrasonic nebulizer in mechanically ventilated rabbits
The deposition efficiency of three methods of aerosol delivery of salbutamol into lungs of ventilated rabbits was compared: 1) metered dose inhaler (MDI) with holding chamber (HC), 2) jet nebulizer (JN), and 3) ultrasonic (US) nebulizer. The latter system was tested using two different sized medicat...
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| Veröffentlicht in: | Pediatric research 1997-11, Vol.42 (5), p.721-727 |
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| creator | FOK, T.-F AL-ESSA, M MONKMAN, S DOLOVICH, M GIRARD, L COATES, G KIRPALANI, H |
| description | The deposition efficiency of three methods of aerosol delivery of salbutamol into lungs of ventilated rabbits was compared: 1) metered dose inhaler (MDI) with holding chamber (HC), 2) jet nebulizer (JN), and 3) ultrasonic (US) nebulizer. The latter system was tested using two different sized medication reservoirs, a large (20 mL) cup (US20) and a small (10 mL) cup (US10). After delivery of technetium-99m-labeled salbutamol aerosol, deposition in the lungs, trachea, and ventilator circuit were estimated by a gamma counter. Total pulmonary deposition [mean(SEM)] as a percentage of the prescribed drug was: MDI + HC 0.22(0.05)%; JN 0.48(0.05)%; US20 0.90(0.13)%; US10 3.05(0.49)%. Only the deposition from the US10 was statistically significantly higher than the other modes (p < 0.05). Dynamic scintigraphy showed that, among the nebulizers, the US10 continued to deliver medication for longer than either the JN or the US20. We conclude that the US10 appears to be more efficient in delivering aerosol to the lung in this rabbit model and merits further evaluation for clinical efficiency. |
| doi_str_mv | 10.1203/00006450-199711000-00027 |
| format | Article |
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The latter system was tested using two different sized medication reservoirs, a large (20 mL) cup (US20) and a small (10 mL) cup (US10). After delivery of technetium-99m-labeled salbutamol aerosol, deposition in the lungs, trachea, and ventilator circuit were estimated by a gamma counter. Total pulmonary deposition [mean(SEM)] as a percentage of the prescribed drug was: MDI + HC 0.22(0.05)%; JN 0.48(0.05)%; US20 0.90(0.13)%; US10 3.05(0.49)%. Only the deposition from the US10 was statistically significantly higher than the other modes (p < 0.05). Dynamic scintigraphy showed that, among the nebulizers, the US10 continued to deliver medication for longer than either the JN or the US20. We conclude that the US10 appears to be more efficient in delivering aerosol to the lung in this rabbit model and merits further evaluation for clinical efficiency.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/00006450-199711000-00027</identifier><identifier>PMID: 9357949</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Administration, Inhalation ; Aerosols ; Albuterol - pharmacokinetics ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Bronchodilator Agents - pharmacokinetics ; Dose-Response Relationship, Drug ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Gamma Rays ; Intensive care medicine ; Medical sciences ; Nebulizers and Vaporizers ; Particle Size ; Rabbits ; Radionuclide Imaging ; Respiration, Artificial ; Trachea - metabolism</subject><ispartof>Pediatric research, 1997-11, Vol.42 (5), p.721-727</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-a5c48aa94b5411db9c8b3601df0c4ec91f658300bd6e6b30f56cbaed94d5c6563</citedby><cites>FETCH-LOGICAL-c389t-a5c48aa94b5411db9c8b3601df0c4ec91f658300bd6e6b30f56cbaed94d5c6563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2055452$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9357949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FOK, T.-F</creatorcontrib><creatorcontrib>AL-ESSA, M</creatorcontrib><creatorcontrib>MONKMAN, S</creatorcontrib><creatorcontrib>DOLOVICH, M</creatorcontrib><creatorcontrib>GIRARD, L</creatorcontrib><creatorcontrib>COATES, G</creatorcontrib><creatorcontrib>KIRPALANI, H</creatorcontrib><title>Pulmonary deposition of salbutamol aerosol delivered by metered dose inhaler, jet nebulizer, and ultrasonic nebulizer in mechanically ventilated rabbits</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><description>The deposition efficiency of three methods of aerosol delivery of salbutamol into lungs of ventilated rabbits was compared: 1) metered dose inhaler (MDI) with holding chamber (HC), 2) jet nebulizer (JN), and 3) ultrasonic (US) nebulizer. The latter system was tested using two different sized medication reservoirs, a large (20 mL) cup (US20) and a small (10 mL) cup (US10). After delivery of technetium-99m-labeled salbutamol aerosol, deposition in the lungs, trachea, and ventilator circuit were estimated by a gamma counter. Total pulmonary deposition [mean(SEM)] as a percentage of the prescribed drug was: MDI + HC 0.22(0.05)%; JN 0.48(0.05)%; US20 0.90(0.13)%; US10 3.05(0.49)%. Only the deposition from the US10 was statistically significantly higher than the other modes (p < 0.05). Dynamic scintigraphy showed that, among the nebulizers, the US10 continued to deliver medication for longer than either the JN or the US20. We conclude that the US10 appears to be more efficient in delivering aerosol to the lung in this rabbit model and merits further evaluation for clinical efficiency.</description><subject>Administration, Inhalation</subject><subject>Aerosols</subject><subject>Albuterol - pharmacokinetics</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bronchodilator Agents - pharmacokinetics</subject><subject>Dose-Response Relationship, Drug</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Gamma Rays</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Nebulizers and Vaporizers</subject><subject>Particle Size</subject><subject>Rabbits</subject><subject>Radionuclide Imaging</subject><subject>Respiration, Artificial</subject><subject>Trachea - metabolism</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUdFuFSEQJUZTb6ufYMKD8clVWGB3eTRN1SZN9EGfNwPMpjQsXIFtcv0SP1faXq8kZBjOmTPJOYRQzj7wnomPrJ1BKtZxrUfOW9e124_PyI4r0Ropx-dkx5jgndB6eknOS7ljjEs1yTNypoUatdQ78uf7FtYUIR-ow30qvvoUaVpogWC2CmsKFDCn0qrD4O8xo6PmQFesj0-XClIfbyFgfk_vsNKIZgv-90ML0dEt1AwlRW__I22gCdhbaL8QwoHeY6w-QG2CGYzxtbwiLxYIBV8f6wX5-fnqx-XX7ubbl-vLTzedFZOuHSgrJwAtjZKcO6PtZMTAuFuYlWg1XwY1CcaMG3Awgi1qsAbQaemUHdQgLsi7J919Tr82LHVefbEYAkRMW5lH3fboXjfi9ES0zY2ScZn32a_NuJmz-SGU-V8o8ymU-TGUNvrmuGMzK7rT4DGFhr894lCaH0uGaH050XqmlFS9-AvG7JjC</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>FOK, T.-F</creator><creator>AL-ESSA, M</creator><creator>MONKMAN, S</creator><creator>DOLOVICH, M</creator><creator>GIRARD, L</creator><creator>COATES, G</creator><creator>KIRPALANI, H</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971101</creationdate><title>Pulmonary deposition of salbutamol aerosol delivered by metered dose inhaler, jet nebulizer, and ultrasonic nebulizer in mechanically ventilated rabbits</title><author>FOK, T.-F ; AL-ESSA, M ; MONKMAN, S ; DOLOVICH, M ; GIRARD, L ; COATES, G ; KIRPALANI, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-a5c48aa94b5411db9c8b3601df0c4ec91f658300bd6e6b30f56cbaed94d5c6563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Administration, Inhalation</topic><topic>Aerosols</topic><topic>Albuterol - pharmacokinetics</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bronchodilator Agents - pharmacokinetics</topic><topic>Dose-Response Relationship, Drug</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Gamma Rays</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Nebulizers and Vaporizers</topic><topic>Particle Size</topic><topic>Rabbits</topic><topic>Radionuclide Imaging</topic><topic>Respiration, Artificial</topic><topic>Trachea - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FOK, T.-F</creatorcontrib><creatorcontrib>AL-ESSA, M</creatorcontrib><creatorcontrib>MONKMAN, S</creatorcontrib><creatorcontrib>DOLOVICH, M</creatorcontrib><creatorcontrib>GIRARD, L</creatorcontrib><creatorcontrib>COATES, G</creatorcontrib><creatorcontrib>KIRPALANI, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FOK, T.-F</au><au>AL-ESSA, M</au><au>MONKMAN, S</au><au>DOLOVICH, M</au><au>GIRARD, L</au><au>COATES, G</au><au>KIRPALANI, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary deposition of salbutamol aerosol delivered by metered dose inhaler, jet nebulizer, and ultrasonic nebulizer in mechanically ventilated rabbits</atitle><jtitle>Pediatric research</jtitle><addtitle>Pediatr Res</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>42</volume><issue>5</issue><spage>721</spage><epage>727</epage><pages>721-727</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>The deposition efficiency of three methods of aerosol delivery of salbutamol into lungs of ventilated rabbits was compared: 1) metered dose inhaler (MDI) with holding chamber (HC), 2) jet nebulizer (JN), and 3) ultrasonic (US) nebulizer. The latter system was tested using two different sized medication reservoirs, a large (20 mL) cup (US20) and a small (10 mL) cup (US10). After delivery of technetium-99m-labeled salbutamol aerosol, deposition in the lungs, trachea, and ventilator circuit were estimated by a gamma counter. Total pulmonary deposition [mean(SEM)] as a percentage of the prescribed drug was: MDI + HC 0.22(0.05)%; JN 0.48(0.05)%; US20 0.90(0.13)%; US10 3.05(0.49)%. Only the deposition from the US10 was statistically significantly higher than the other modes (p < 0.05). Dynamic scintigraphy showed that, among the nebulizers, the US10 continued to deliver medication for longer than either the JN or the US20. We conclude that the US10 appears to be more efficient in delivering aerosol to the lung in this rabbit model and merits further evaluation for clinical efficiency.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9357949</pmid><doi>10.1203/00006450-199711000-00027</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatric research, 1997-11, Vol.42 (5), p.721-727 |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Administration, Inhalation Aerosols Albuterol - pharmacokinetics Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bronchodilator Agents - pharmacokinetics Dose-Response Relationship, Drug Emergency and intensive care: neonates and children. Prematurity. Sudden death Gamma Rays Intensive care medicine Medical sciences Nebulizers and Vaporizers Particle Size Rabbits Radionuclide Imaging Respiration, Artificial Trachea - metabolism |
| title | Pulmonary deposition of salbutamol aerosol delivered by metered dose inhaler, jet nebulizer, and ultrasonic nebulizer in mechanically ventilated rabbits |
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