The successful treatment of finger Trichophyton rubrum onychomycosis with oral terbinafine
Summary Eleven patients with distal subungal onychomycosis of the fingers by Trichophyton rubrum infection were treated with daily doses of oral terbinafine, a new allylamine derivative. A 125‐mg capsule was given twice daily. Each patient's nailplate was marked appropriately following the Zaia...
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| Veröffentlicht in: | Clinical and experimental dermatology 1989-03, Vol.14 (2), p.120-123 |
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| container_title | Clinical and experimental dermatology |
| container_volume | 14 |
| creator | ZAIAS, N. SERRANO, L. |
| description | Summary
Eleven patients with distal subungal onychomycosis of the fingers by Trichophyton rubrum infection were treated with daily doses of oral terbinafine, a new allylamine derivative. A 125‐mg capsule was given twice daily. Each patient's nailplate was marked appropriately following the Zaias and Drachman method for the determination of antifungal efficacy in onychomycosis.1 Patients were monitored monthly for the antifungal effect of the drug, as well as side‐effects, including laboratory values for liver and kidney function tests and a full blood count. At the end of 6 months, all 11 patients were clinically and mycologically normal. It can be concluded that 250 mg (125 mg b.i.d.) oral terbinafine is the most appropriate drug for the treatment of finger onychomycosis. No side‐effects of any kind were noted in this 6‐month period. |
| doi_str_mv | 10.1111/j.1365-2230.1989.tb00907.x |
| format | Article |
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Eleven patients with distal subungal onychomycosis of the fingers by Trichophyton rubrum infection were treated with daily doses of oral terbinafine, a new allylamine derivative. A 125‐mg capsule was given twice daily. Each patient's nailplate was marked appropriately following the Zaias and Drachman method for the determination of antifungal efficacy in onychomycosis.1 Patients were monitored monthly for the antifungal effect of the drug, as well as side‐effects, including laboratory values for liver and kidney function tests and a full blood count. At the end of 6 months, all 11 patients were clinically and mycologically normal. It can be concluded that 250 mg (125 mg b.i.d.) oral terbinafine is the most appropriate drug for the treatment of finger onychomycosis. No side‐effects of any kind were noted in this 6‐month period.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/j.1365-2230.1989.tb00907.x</identifier><identifier>PMID: 2532084</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Oral ; Antifungal Agents - administration & dosage ; Hand Dermatoses - drug therapy ; Humans ; Male ; Naphthalenes - administration & dosage ; Onychomycosis - drug therapy ; Terbinafine ; Trichophyton</subject><ispartof>Clinical and experimental dermatology, 1989-03, Vol.14 (2), p.120-123</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4070-46009beef55781f6c655c36b2d5c17561fb28b544164fee09d87a939059bfc2d3</citedby><cites>FETCH-LOGICAL-c4070-46009beef55781f6c655c36b2d5c17561fb28b544164fee09d87a939059bfc2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2532084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZAIAS, N.</creatorcontrib><creatorcontrib>SERRANO, L.</creatorcontrib><title>The successful treatment of finger Trichophyton rubrum onychomycosis with oral terbinafine</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Eleven patients with distal subungal onychomycosis of the fingers by Trichophyton rubrum infection were treated with daily doses of oral terbinafine, a new allylamine derivative. A 125‐mg capsule was given twice daily. Each patient's nailplate was marked appropriately following the Zaias and Drachman method for the determination of antifungal efficacy in onychomycosis.1 Patients were monitored monthly for the antifungal effect of the drug, as well as side‐effects, including laboratory values for liver and kidney function tests and a full blood count. At the end of 6 months, all 11 patients were clinically and mycologically normal. It can be concluded that 250 mg (125 mg b.i.d.) oral terbinafine is the most appropriate drug for the treatment of finger onychomycosis. No side‐effects of any kind were noted in this 6‐month period.</description><subject>Administration, Oral</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Hand Dermatoses - drug therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Naphthalenes - administration & dosage</subject><subject>Onychomycosis - drug therapy</subject><subject>Terbinafine</subject><subject>Trichophyton</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1v0zAYxy3ENMrGR0CyOHBLZ8exHXNAYmVsExPsUATiYsXuY-qSxMVOtObbz1Wr3vHF0vN_8eMfQu8omdN8rjZzygQvypLlgarVfDCEKCLnuxdodpJeohlhRBZCsfoVep3ShhDKqOTn6LzkrCR1NUO_l2vAabQWUnJji4cIzdBBP-DgsPP9H4h4Gb1dh-16GkKP42ji2OHQT3nWTTYkn_CTH9Y4xCbnIRrfNzkJl-jMNW2CN8f7Av34crNc3BUP32_vF58eClsRSYpK5N0NgONc1tQJKzi3TJhyxW1eVlBnytrwqqKicgBErWrZKKYIV8bZcsUu0PtD7zaGfyOkQXc-WWjbpocwJi3z_7NfZeOHg9HGkFIEp7fRd02cNCV6D1Zv9J6e3tPTe7D6CFbvcvjt8ZXRdLA6RY8ks_7xoD_5Fqb_aNaLm8-0JLmgOBT4NMDuVNDEv1pIJrn--e1W8zvKyPXXX_qRPQO7IZi_</recordid><startdate>198903</startdate><enddate>198903</enddate><creator>ZAIAS, N.</creator><creator>SERRANO, L.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198903</creationdate><title>The successful treatment of finger Trichophyton rubrum onychomycosis with oral terbinafine</title><author>ZAIAS, N. ; SERRANO, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4070-46009beef55781f6c655c36b2d5c17561fb28b544164fee09d87a939059bfc2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Administration, Oral</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Hand Dermatoses - drug therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Naphthalenes - administration & dosage</topic><topic>Onychomycosis - drug therapy</topic><topic>Terbinafine</topic><topic>Trichophyton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZAIAS, N.</creatorcontrib><creatorcontrib>SERRANO, L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZAIAS, N.</au><au>SERRANO, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The successful treatment of finger Trichophyton rubrum onychomycosis with oral terbinafine</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>1989-03</date><risdate>1989</risdate><volume>14</volume><issue>2</issue><spage>120</spage><epage>123</epage><pages>120-123</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><abstract>Summary
Eleven patients with distal subungal onychomycosis of the fingers by Trichophyton rubrum infection were treated with daily doses of oral terbinafine, a new allylamine derivative. A 125‐mg capsule was given twice daily. Each patient's nailplate was marked appropriately following the Zaias and Drachman method for the determination of antifungal efficacy in onychomycosis.1 Patients were monitored monthly for the antifungal effect of the drug, as well as side‐effects, including laboratory values for liver and kidney function tests and a full blood count. At the end of 6 months, all 11 patients were clinically and mycologically normal. It can be concluded that 250 mg (125 mg b.i.d.) oral terbinafine is the most appropriate drug for the treatment of finger onychomycosis. No side‐effects of any kind were noted in this 6‐month period.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2532084</pmid><doi>10.1111/j.1365-2230.1989.tb00907.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-6938 |
| ispartof | Clinical and experimental dermatology, 1989-03, Vol.14 (2), p.120-123 |
| issn | 0307-6938 1365-2230 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Administration, Oral Antifungal Agents - administration & dosage Hand Dermatoses - drug therapy Humans Male Naphthalenes - administration & dosage Onychomycosis - drug therapy Terbinafine Trichophyton |
| title | The successful treatment of finger Trichophyton rubrum onychomycosis with oral terbinafine |
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