Parsing Schizophrenia with Neurocognitive Tests: Evidence of Stability and Validity
The stability and validity of a neurocognitive typology for schizophrenia were studied in 55 chronic patients who met DSMIII-R criteria for the illness. Subtypes were based on an earlier cluster analytic study by Heinrichs and Awad (1993) that utilized the following variables: IQ (WAIS-R), categorie...
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| Veröffentlicht in: | Brain and cognition 1997-11, Vol.35 (2), p.207-224 |
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| creator | Heinrichs, R.Walter Ruttan, Lesley Zakzanis, Konstantine K. Case, Danielle |
| description | The stability and validity of a neurocognitive typology for schizophrenia were studied in 55 chronic patients who met DSMIII-R criteria for the illness. Subtypes were based on an earlier cluster analytic study by Heinrichs and Awad (1993) that utilized the following variables: IQ (WAIS-R), categories (Wisconsin Card Sorting Test), free recall intrusions (California Verbal Learning Test), and bilateral motor performance (Purdue Pegboard). Stability was examined by analyzing subtype assignment at the original assessment and 3 years later at follow-up. Stability over this interval was variable with an overall kappa of .45 and individual kappas from .12 to .66. Adjunct cognitive and clinical data gathered at follow-up provide evidence for the validity of several subtypes, especially in terms of their cognitive and functional differences. There was no evidence of symptom differences in this relatively asymptomatic medicated sample of patients. The results are discussed in terms of the possibility that several patterns of neurocognitive dysfunction may underlie schizophrenia, with implications for understanding the heterogeneity of the illness and its variable functional outcomes. |
| doi_str_mv | 10.1006/brcg.1997.0938 |
| format | Article |
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The results are discussed in terms of the possibility that several patterns of neurocognitive dysfunction may underlie schizophrenia, with implications for understanding the heterogeneity of the illness and its variable functional outcomes.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Psychiatry</topic><topic>Psychoses</topic><topic>Reproducibility of Results</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heinrichs, R.Walter</creatorcontrib><creatorcontrib>Ruttan, Lesley</creatorcontrib><creatorcontrib>Zakzanis, Konstantine K.</creatorcontrib><creatorcontrib>Case, Danielle</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Brain and cognition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heinrichs, R.Walter</au><au>Ruttan, Lesley</au><au>Zakzanis, Konstantine K.</au><au>Case, Danielle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parsing Schizophrenia with Neurocognitive Tests: Evidence of Stability and Validity</atitle><jtitle>Brain and cognition</jtitle><addtitle>Brain Cogn</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>35</volume><issue>2</issue><spage>207</spage><epage>224</epage><pages>207-224</pages><issn>0278-2626</issn><eissn>1090-2147</eissn><coden>BRCOEI</coden><abstract>The stability and validity of a neurocognitive typology for schizophrenia were studied in 55 chronic patients who met DSMIII-R criteria for the illness. 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| ispartof | Brain and cognition, 1997-11, Vol.35 (2), p.207-224 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Chronic Disease Cognition Disorders - diagnosis Cognition Disorders - etiology Female Follow-Up Studies Humans Male Medical sciences Middle Aged Neuropsychological Tests Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reproducibility of Results Schizophrenia Schizophrenia - complications |
| title | Parsing Schizophrenia with Neurocognitive Tests: Evidence of Stability and Validity |
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