Effect of fluconazole on the pharmacokinetics of eprosartan and losartan in healthy male volunteers

Objective To investigate the effect of steady‐state fluconazole administration on the disposition of eprosartan, losartan, and E‐3174. Methods Sixteen healthy male subjects received 300 mg eprosartan every 12 hours, and 16 received 100 mg losartan every 24 hours on study days 1 to 20. All 32 subject...

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