DNA Gyrase Inhibitory and Antimicrobial Activities of Some Diphenic Acid Monohydroxamides

The synthesis and inhibitory activity against DNA gyrase of a series of diphenic acid monohydroxamides 4a − f are described. A protocol of two biological assays showed conclusively that inhibition occurs specifically at the DNA−DNA gyrase complex and is not attributable to nonspecific inhibition. In...

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Veröffentlicht in:	Journal of medicinal chemistry 1997-09, Vol.40 (20), p.3292-3296
Hauptverfasser:	Ohemeng, Kwasi A, Podlogar, Brent L, Nguyen, Van N, Bernstein, Jeffrey I, Krause, Heather M, Hilliard, Jamese J, Barrett, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Biphenyl Compounds - chemistry Biphenyl Compounds - pharmacology Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Escherichia coli - enzymology Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Medical sciences Models, Chemical Models, Molecular Pharmacology. Drug treatments Topoisomerase II Inhibitors
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