Concomitant and hormonally regulated expression of trp genes in bovine aortic endothelial cells
Recent findings have suggested that the vertebrate trp family of channel proteins is the structural basis for Ca 2+ influx through the capacitative calcium entry (CCE) pathway. We have discerned, in bovine aortic endothelial cells, the concomitant expression of four such vertebrate genes: trp-1 (two...
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| Veröffentlicht in: | FEBS letters 1997-10, Vol.415 (3), p.335-340 |
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| creator | Chang, Albert S. Chang, Sharon M. Garcia, Reynaldo L. Schilling, William P. |
| description | Recent findings have suggested that the vertebrate
trp family of channel proteins is the structural basis for Ca
2+ influx through the capacitative calcium entry (CCE) pathway. We have discerned, in bovine aortic endothelial cells, the concomitant expression of four such vertebrate genes:
trp-1 (two splice variants),
trp-3,
trp-4 and
trp-5. Exogenous hormones rendered dynamic effects on the transcript levels of these genes. Most notably, β-estradiol significantly down-regulated
trp-4 while
trans-retinoic acid dramatically up-regulated
trp-5; yet these hormones rendered little change in CCE. These findings suggest that the extent of a given
trp channel's participation in CCE is not reflected in alterations of its transcript level. |
| doi_str_mv | 10.1016/S0014-5793(97)01155-1 |
| format | Article |
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trp family of channel proteins is the structural basis for Ca
2+ influx through the capacitative calcium entry (CCE) pathway. We have discerned, in bovine aortic endothelial cells, the concomitant expression of four such vertebrate genes:
trp-1 (two splice variants),
trp-3,
trp-4 and
trp-5. Exogenous hormones rendered dynamic effects on the transcript levels of these genes. Most notably, β-estradiol significantly down-regulated
trp-4 while
trans-retinoic acid dramatically up-regulated
trp-5; yet these hormones rendered little change in CCE. These findings suggest that the extent of a given
trp channel's participation in CCE is not reflected in alterations of its transcript level.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(97)01155-1</identifier><identifier>PMID: 9357995</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Aorta ; Blotting, Southern ; Calcium - metabolism ; Calcium Channels - biosynthesis ; Calcium Channels - genetics ; Capacitative calcium entry ; Cattle ; Cells, Cultured ; DNA Primers ; Endothelium, Vascular - cytology ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - metabolism ; Estradiol - pharmacology ; Fura-2 ; Gene Expression Regulation - drug effects ; Hormones - pharmacology ; Molecular Sequence Data ; Polymerase Chain Reaction ; Semi-quantitative PCR ; Sequence Alignment ; Sequence Analysis, DNA ; Steroid hormone ; Thapsigargin ; Tretinoin - pharmacology ; TRPC Cation Channels ; Vascular endothelium</subject><ispartof>FEBS letters, 1997-10, Vol.415 (3), p.335-340</ispartof><rights>1997 Federation of European Biochemical Societies</rights><rights>FEBS Letters 415 (1997) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4721-b79507f982c8b5fa422651e93d09c71ac495c8329b69541b12a63c46520f1a653</citedby><cites>FETCH-LOGICAL-c4721-b79507f982c8b5fa422651e93d09c71ac495c8329b69541b12a63c46520f1a653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0014-5793%2897%2901155-1$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0014-5793(97)01155-1$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,1433,3550,27924,27925,45574,45575,45995,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9357995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Albert S.</creatorcontrib><creatorcontrib>Chang, Sharon M.</creatorcontrib><creatorcontrib>Garcia, Reynaldo L.</creatorcontrib><creatorcontrib>Schilling, William P.</creatorcontrib><title>Concomitant and hormonally regulated expression of trp genes in bovine aortic endothelial cells</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Recent findings have suggested that the vertebrate
trp family of channel proteins is the structural basis for Ca
2+ influx through the capacitative calcium entry (CCE) pathway. We have discerned, in bovine aortic endothelial cells, the concomitant expression of four such vertebrate genes:
trp-1 (two splice variants),
trp-3,
trp-4 and
trp-5. Exogenous hormones rendered dynamic effects on the transcript levels of these genes. Most notably, β-estradiol significantly down-regulated
trp-4 while
trans-retinoic acid dramatically up-regulated
trp-5; yet these hormones rendered little change in CCE. These findings suggest that the extent of a given
trp channel's participation in CCE is not reflected in alterations of its transcript level.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Aorta</subject><subject>Blotting, Southern</subject><subject>Calcium - metabolism</subject><subject>Calcium Channels - biosynthesis</subject><subject>Calcium Channels - genetics</subject><subject>Capacitative calcium entry</subject><subject>Cattle</subject><subject>Cells, Cultured</subject><subject>DNA Primers</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Estradiol - pharmacology</subject><subject>Fura-2</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Hormones - pharmacology</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>Semi-quantitative PCR</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, DNA</subject><subject>Steroid hormone</subject><subject>Thapsigargin</subject><subject>Tretinoin - pharmacology</subject><subject>TRPC Cation Channels</subject><subject>Vascular endothelium</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9P4zAQxS3ECsqfj4DkE2IP2fUkcRyfEFSwrITEAThbjjMBI8cudlq2356krbiyp9HMe_Nm9CPkDNgvYFD9fmQMyowLWVxI8ZMBcJ7BHplBLYqsKKt6n8y-LIfkKKU3NvY1yANyIItxKvmMqHnwJvR20H6g2rf0NcQ-eO3cmkZ8WTo9YEvx3yJiSjZ4Gjo6xAV9QY-JWk-bsLIeqQ5xsIaib8Pwis5qRw06l07Ij067hKe7ekyeb2-e5nfZ_cOfv_Or-8yUIoesEZIz0ck6N3XDO13mecUBZdEyaQRoU0pu6iKXTSV5CQ3kuipMWfGcdaArXhyT823uIob3JaZB9TZNH2iPYZnUyKDmUMrRyLdGE0NKETu1iLbXca2AqQms2oBVEzUlhdqAVTDune0OLJse26-tHclRv9vqH9bh-v9C1e3Ndb5RJkGKzXg6dbmNwhHYymJUyVj0Blsb0QyqDfabZz8BUvacAg</recordid><startdate>19971006</startdate><enddate>19971006</enddate><creator>Chang, Albert S.</creator><creator>Chang, Sharon M.</creator><creator>Garcia, Reynaldo L.</creator><creator>Schilling, William P.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971006</creationdate><title>Concomitant and hormonally regulated expression of trp genes in bovine aortic endothelial cells</title><author>Chang, Albert S. ; Chang, Sharon M. ; Garcia, Reynaldo L. ; Schilling, William P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4721-b79507f982c8b5fa422651e93d09c71ac495c8329b69541b12a63c46520f1a653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Aorta</topic><topic>Blotting, Southern</topic><topic>Calcium - metabolism</topic><topic>Calcium Channels - biosynthesis</topic><topic>Calcium Channels - genetics</topic><topic>Capacitative calcium entry</topic><topic>Cattle</topic><topic>Cells, Cultured</topic><topic>DNA Primers</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Estradiol - pharmacology</topic><topic>Fura-2</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Hormones - pharmacology</topic><topic>Molecular Sequence Data</topic><topic>Polymerase Chain Reaction</topic><topic>Semi-quantitative PCR</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, DNA</topic><topic>Steroid hormone</topic><topic>Thapsigargin</topic><topic>Tretinoin - pharmacology</topic><topic>TRPC Cation Channels</topic><topic>Vascular endothelium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Albert S.</creatorcontrib><creatorcontrib>Chang, Sharon M.</creatorcontrib><creatorcontrib>Garcia, Reynaldo L.</creatorcontrib><creatorcontrib>Schilling, William P.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Albert S.</au><au>Chang, Sharon M.</au><au>Garcia, Reynaldo L.</au><au>Schilling, William P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concomitant and hormonally regulated expression of trp genes in bovine aortic endothelial cells</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1997-10-06</date><risdate>1997</risdate><volume>415</volume><issue>3</issue><spage>335</spage><epage>340</epage><pages>335-340</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Recent findings have suggested that the vertebrate
trp family of channel proteins is the structural basis for Ca
2+ influx through the capacitative calcium entry (CCE) pathway. We have discerned, in bovine aortic endothelial cells, the concomitant expression of four such vertebrate genes:
trp-1 (two splice variants),
trp-3,
trp-4 and
trp-5. Exogenous hormones rendered dynamic effects on the transcript levels of these genes. Most notably, β-estradiol significantly down-regulated
trp-4 while
trans-retinoic acid dramatically up-regulated
trp-5; yet these hormones rendered little change in CCE. These findings suggest that the extent of a given
trp channel's participation in CCE is not reflected in alterations of its transcript level.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>9357995</pmid><doi>10.1016/S0014-5793(97)01155-1</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Free Content; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Aorta Blotting, Southern Calcium - metabolism Calcium Channels - biosynthesis Calcium Channels - genetics Capacitative calcium entry Cattle Cells, Cultured DNA Primers Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Estradiol - pharmacology Fura-2 Gene Expression Regulation - drug effects Hormones - pharmacology Molecular Sequence Data Polymerase Chain Reaction Semi-quantitative PCR Sequence Alignment Sequence Analysis, DNA Steroid hormone Thapsigargin Tretinoin - pharmacology TRPC Cation Channels Vascular endothelium |
| title | Concomitant and hormonally regulated expression of trp genes in bovine aortic endothelial cells |
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