Synthesis of Macromolecular Prodrugs of Procaine, Histamine and Isoniazid

The attachment of various drugs bearing-NH2 groups to poly-α, β-aspartic acid as a biodegradable carrier afforded in good yields macromolecular prodrugs which were characterized with respect to composition and drug load by spectroscopic and analytical method. N-Ethyl-N'-(3-dimethylaminopropyl)c...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1989/08/25, Vol.37(8), pp.2245-2247
Hauptverfasser:	GIAMMONA, Gaetano, GIANNOLA, Libero Italo, CARLISI, Bianca, BAJARDI, Maria Luisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemical Phenomena Chemistry General pharmacology histamine Histamine - administration & dosage Histamine - analogs & derivatives isoniazid Isoniazid - administration & dosage Isoniazid - analogs & derivatives macromolecular prodrug Medical sciences Molecular Weight pendant-chains system Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments poly-α, β-aspartic acid procaine Procaine - administration & dosage Procaine - analogs & derivatives Prodrugs - chemical synthesis
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