The ubiquitin system

The ubiquitin system

Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Trends in Biochemical Sciences 1997-10, Vol.22 (10), p.383-387
1. Verfasser: Varshavsky, Alexander
Format: Artikel
Sprache:eng
Schlagworte:
Cysteine Endopeptidases - chemistry
Multienzyme Complexes - chemistry
Proteasome Endopeptidase Complex
Proteins - chemistry
Ubiquitins - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(97)01122-5