Sodium nuclear magnetic resonance imaging of acute cardiac rejection in heterotopic heart transplantation
Nuclear magnetic resonance (NMR) imaging was used to measure tissue sodium-23 in the myocardium undergoing cardiac rejection. In six dogs, the donor heart was heterotopically transplanted into the recipient's chest cavity. The dogs were then killed and sodium-23 images of the excised hearts wer...
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| Veröffentlicht in: | Cardiovascular research 1989-07, Vol.23 (7), p.561-566 |
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| container_title | Cardiovascular research |
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| creator | NISHIMURA, TSUNEHIKO SADA, MASAHARU SASAKI, HIDEMIKI YAMADA, NAOAKI YAMADA, YUKINORI YUTANI, CHIKAO AMEMIYA, HIROSHI FUJITA, TSUYOSHI AKUTSU, TETSUZO MANABE, HISAO |
| description | Nuclear magnetic resonance (NMR) imaging was used to measure tissue sodium-23 in the myocardium undergoing cardiac rejection. In six dogs, the donor heart was heterotopically transplanted into the recipient's chest cavity. The dogs were then killed and sodium-23 images of the excised hearts were obtained using a high field (1.5 Tesla) NMR imaging system. Proton NMR imaging of each excised heart was also performed and T1, T2 relaxation times were calculated. Subsequently, these data were correlated with pathological findings of mild, moderate and severe rejection. The correlation coefficients between the rejection score and the T1, T2 relaxation times and sodium NMR signal intensity were 0.79, 0.70 and 0.84, respectively. Severely rejected areas of the myocardium were visualised by increased sodium NMR signals. These findings suggest that an increase of sodium NMR intensity is mainly caused by an increase of intracellular sodium content due to irreversible myocardial necrosis. Sodium NMR allows evaluation of the location and extent of rejection of myocardium after heart transplantation. |
| doi_str_mv | 10.1093/cvr/23.7.561 |
| format | Article |
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In six dogs, the donor heart was heterotopically transplanted into the recipient's chest cavity. The dogs were then killed and sodium-23 images of the excised hearts were obtained using a high field (1.5 Tesla) NMR imaging system. Proton NMR imaging of each excised heart was also performed and T1, T2 relaxation times were calculated. Subsequently, these data were correlated with pathological findings of mild, moderate and severe rejection. The correlation coefficients between the rejection score and the T1, T2 relaxation times and sodium NMR signal intensity were 0.79, 0.70 and 0.84, respectively. Severely rejected areas of the myocardium were visualised by increased sodium NMR signals. These findings suggest that an increase of sodium NMR intensity is mainly caused by an increase of intracellular sodium content due to irreversible myocardial necrosis. Sodium NMR allows evaluation of the location and extent of rejection of myocardium after heart transplantation.</description><identifier>ISSN: 0008-6363</identifier><identifier>EISSN: 1755-3245</identifier><identifier>DOI: 10.1093/cvr/23.7.561</identifier><identifier>PMID: 2598211</identifier><identifier>CODEN: CVREAU</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; cardiac rejection ; Dogs ; Graft Rejection ; Heart Septal Defects, Atrial - pathology ; Heart Transplantation - pathology ; heterotopic heart transplantation ; Intracellular Fluid - analysis ; Magnetic Resonance Imaging ; Medical sciences ; Myocardium - pathology ; Necrosis ; Orthopedic surgery ; Sodium - analysis ; sodium MRI ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Thorax ; Transplantation, Heterotopic ; Tricuspid Valve Insufficiency - pathology</subject><ispartof>Cardiovascular research, 1989-07, Vol.23 (7), p.561-566</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-a1956dcd752d15298a753a2a0ca8631a83574a43e5ca3e70c7a831bf696adf4c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7373390$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2598211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NISHIMURA, TSUNEHIKO</creatorcontrib><creatorcontrib>SADA, MASAHARU</creatorcontrib><creatorcontrib>SASAKI, HIDEMIKI</creatorcontrib><creatorcontrib>YAMADA, NAOAKI</creatorcontrib><creatorcontrib>YAMADA, YUKINORI</creatorcontrib><creatorcontrib>YUTANI, CHIKAO</creatorcontrib><creatorcontrib>AMEMIYA, HIROSHI</creatorcontrib><creatorcontrib>FUJITA, TSUYOSHI</creatorcontrib><creatorcontrib>AKUTSU, TETSUZO</creatorcontrib><creatorcontrib>MANABE, HISAO</creatorcontrib><title>Sodium nuclear magnetic resonance imaging of acute cardiac rejection in heterotopic heart transplantation</title><title>Cardiovascular research</title><addtitle>Cardiovasc Res</addtitle><description>Nuclear magnetic resonance (NMR) imaging was used to measure tissue sodium-23 in the myocardium undergoing cardiac rejection. In six dogs, the donor heart was heterotopically transplanted into the recipient's chest cavity. The dogs were then killed and sodium-23 images of the excised hearts were obtained using a high field (1.5 Tesla) NMR imaging system. Proton NMR imaging of each excised heart was also performed and T1, T2 relaxation times were calculated. Subsequently, these data were correlated with pathological findings of mild, moderate and severe rejection. The correlation coefficients between the rejection score and the T1, T2 relaxation times and sodium NMR signal intensity were 0.79, 0.70 and 0.84, respectively. Severely rejected areas of the myocardium were visualised by increased sodium NMR signals. These findings suggest that an increase of sodium NMR intensity is mainly caused by an increase of intracellular sodium content due to irreversible myocardial necrosis. Sodium NMR allows evaluation of the location and extent of rejection of myocardium after heart transplantation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>cardiac rejection</subject><subject>Dogs</subject><subject>Graft Rejection</subject><subject>Heart Septal Defects, Atrial - pathology</subject><subject>Heart Transplantation - pathology</subject><subject>heterotopic heart transplantation</subject><subject>Intracellular Fluid - analysis</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Myocardium - pathology</subject><subject>Necrosis</subject><subject>Orthopedic surgery</subject><subject>Sodium - analysis</subject><subject>sodium MRI</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Thorax</subject><subject>Transplantation, Heterotopic</subject><subject>Tricuspid Valve Insufficiency - pathology</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFvGyEQhVHUKnHT3nKNxKHqKesAs8DuMbKapG2kHtpKVS5owrIJyRpcYKvm3xfLlk8j5n3zxHuEnHG25KyHS_s3XQpY6qVU_IgsuJayAdHKN2TBGOsaBQpOyLucn-tTSt0ek2Mh-05wviD-Rxz8vKZhtpPDRNf4GFzxliaXY8BgHfV158MjjSNFOxdHLabB4xZ5drb4GKgP9MkVl2KJm3r7VJ0KLQlD3kwYCm6h9-TtiFN2H_bzlPy6_vxzddvcfb_5srq6a2wroDTIe6kGO2gpBi5F36GWgAKZxU4Bxw5qAmzBSYvgNLO6rvjDqHqFw9haOCWfdr6bFP_MLhez9tm6qX7ExTkb3UPHO6kqeLEDbYo5JzeaTapZ06vhzGybNbVZI8BoU5ut-Pned35Yu-EA76us-se9jtniNNb01ucDpkED9KxizQ7zubh_BxnTi1GVkeb2972Bm_7b9dd7Zjr4D4_Gkgs</recordid><startdate>19890701</startdate><enddate>19890701</enddate><creator>NISHIMURA, TSUNEHIKO</creator><creator>SADA, MASAHARU</creator><creator>SASAKI, HIDEMIKI</creator><creator>YAMADA, NAOAKI</creator><creator>YAMADA, YUKINORI</creator><creator>YUTANI, CHIKAO</creator><creator>AMEMIYA, HIROSHI</creator><creator>FUJITA, TSUYOSHI</creator><creator>AKUTSU, TETSUZO</creator><creator>MANABE, HISAO</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890701</creationdate><title>Sodium nuclear magnetic resonance imaging of acute cardiac rejection in heterotopic heart transplantation</title><author>NISHIMURA, TSUNEHIKO ; SADA, MASAHARU ; SASAKI, HIDEMIKI ; YAMADA, NAOAKI ; YAMADA, YUKINORI ; YUTANI, CHIKAO ; AMEMIYA, HIROSHI ; FUJITA, TSUYOSHI ; AKUTSU, TETSUZO ; MANABE, HISAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-a1956dcd752d15298a753a2a0ca8631a83574a43e5ca3e70c7a831bf696adf4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>cardiac rejection</topic><topic>Dogs</topic><topic>Graft Rejection</topic><topic>Heart Septal Defects, Atrial - pathology</topic><topic>Heart Transplantation - pathology</topic><topic>heterotopic heart transplantation</topic><topic>Intracellular Fluid - analysis</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Myocardium - pathology</topic><topic>Necrosis</topic><topic>Orthopedic surgery</topic><topic>Sodium - analysis</topic><topic>sodium MRI</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Thorax</topic><topic>Transplantation, Heterotopic</topic><topic>Tricuspid Valve Insufficiency - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NISHIMURA, TSUNEHIKO</creatorcontrib><creatorcontrib>SADA, MASAHARU</creatorcontrib><creatorcontrib>SASAKI, HIDEMIKI</creatorcontrib><creatorcontrib>YAMADA, NAOAKI</creatorcontrib><creatorcontrib>YAMADA, YUKINORI</creatorcontrib><creatorcontrib>YUTANI, CHIKAO</creatorcontrib><creatorcontrib>AMEMIYA, HIROSHI</creatorcontrib><creatorcontrib>FUJITA, TSUYOSHI</creatorcontrib><creatorcontrib>AKUTSU, TETSUZO</creatorcontrib><creatorcontrib>MANABE, HISAO</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NISHIMURA, TSUNEHIKO</au><au>SADA, MASAHARU</au><au>SASAKI, HIDEMIKI</au><au>YAMADA, NAOAKI</au><au>YAMADA, YUKINORI</au><au>YUTANI, CHIKAO</au><au>AMEMIYA, HIROSHI</au><au>FUJITA, TSUYOSHI</au><au>AKUTSU, TETSUZO</au><au>MANABE, HISAO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sodium nuclear magnetic resonance imaging of acute cardiac rejection in heterotopic heart transplantation</atitle><jtitle>Cardiovascular research</jtitle><addtitle>Cardiovasc Res</addtitle><date>1989-07-01</date><risdate>1989</risdate><volume>23</volume><issue>7</issue><spage>561</spage><epage>566</epage><pages>561-566</pages><issn>0008-6363</issn><eissn>1755-3245</eissn><coden>CVREAU</coden><abstract>Nuclear magnetic resonance (NMR) imaging was used to measure tissue sodium-23 in the myocardium undergoing cardiac rejection. In six dogs, the donor heart was heterotopically transplanted into the recipient's chest cavity. The dogs were then killed and sodium-23 images of the excised hearts were obtained using a high field (1.5 Tesla) NMR imaging system. Proton NMR imaging of each excised heart was also performed and T1, T2 relaxation times were calculated. Subsequently, these data were correlated with pathological findings of mild, moderate and severe rejection. The correlation coefficients between the rejection score and the T1, T2 relaxation times and sodium NMR signal intensity were 0.79, 0.70 and 0.84, respectively. Severely rejected areas of the myocardium were visualised by increased sodium NMR signals. These findings suggest that an increase of sodium NMR intensity is mainly caused by an increase of intracellular sodium content due to irreversible myocardial necrosis. Sodium NMR allows evaluation of the location and extent of rejection of myocardium after heart transplantation.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>2598211</pmid><doi>10.1093/cvr/23.7.561</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences cardiac rejection Dogs Graft Rejection Heart Septal Defects, Atrial - pathology Heart Transplantation - pathology heterotopic heart transplantation Intracellular Fluid - analysis Magnetic Resonance Imaging Medical sciences Myocardium - pathology Necrosis Orthopedic surgery Sodium - analysis sodium MRI Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thorax Transplantation, Heterotopic Tricuspid Valve Insufficiency - pathology |
| title | Sodium nuclear magnetic resonance imaging of acute cardiac rejection in heterotopic heart transplantation |
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