MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells

The Mxi1 protein functions in a regulatory network with members of the c-Myc family, in which c-Myc activates transcription and stimulates cell proliferation, and Mxi1 negatively regulates these actions. Inactivation of the MXI1 gene could, therefore, inhibit differentiation and enhance proliferatio...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-11, Vol.57 (21), p.4905-4912
Hauptverfasser:	WECHSLER, D. S, SHELLY, C. A, PETROFF, C. A, DANG, C. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors Biological and medical sciences Cell Division - genetics Chromosomes, Human, Pair 10 - genetics Dexamethasone - pharmacology DNA-Binding Proteins - drug effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism G2 Phase - genetics Gene Deletion Genes, Tumor Suppressor - physiology Genetic Vectors - drug effects Genetic Vectors - genetics Glioblastoma - genetics Glioblastoma - pathology Glucocorticoids - pharmacology Humans Medical sciences Neurology Transcription Factors - drug effects Transcription Factors - genetics Transcription Factors - metabolism Transfection Tumor Suppressor Proteins Tumors of the nervous system. Phacomatoses
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