Inhibition of HIV-1 Infection by the β-Chemokine MDC

CD8$^+$ T lymphocytes from individuals infected with human immunodeficiency virus-type 1 (HIV-1) secrete a soluble activity that suppresses infection by HIV-1. A protein associated with this activity was purified from the culture supernatant of an immortalized CD8$^+$ T cell clone and identified as...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1997-10, Vol.278 (5338), p.695-698
Hauptverfasser:	Pal, Ranajit, Garzino-Demo, Alfredo, Markham, Phillip D., Burns, Jennifer, Brown, Michelle, Gallo, Robert C., DeVico, Anthony L.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Amino acids Antiviral Agents - immunology Biological and medical sciences Blotting, Northern Calcium - blood CD8-Positive T-Lymphocytes - immunology Cell Line Cell Line, Transformed Cell lines Cells, Cultured Cellular biology Chemokine CCL22 Chemokines Chemokines, CC - chemistry Chemokines, CC - immunology Chemokines, CC - isolation & purification Chemokines, CC - metabolism Cultured cells Cytokines Fractions Fundamental and applied biological sciences. Psychology HIV HIV (Viruses) HIV 1 HIV Core Protein p24 - biosynthesis HIV infection HIV infections HIV Infections - immunology HIV-1 - immunology HIV-1 - physiology Human immunodeficiency virus Humans Inactivation Infections Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - virology Lymphocyte Activation Microbiology Physiological aspects Prevention Receptors Receptors, Chemokine - metabolism Receptors, HIV - metabolism Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains RNA T cells T lymphocytes T-Lymphocytes - immunology Virology Virus inactivation Viruses
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