Inhibition of HIV-1 Infection by the β-Chemokine MDC
CD8$^+$ T lymphocytes from individuals infected with human immunodeficiency virus-type 1 (HIV-1) secrete a soluble activity that suppresses infection by HIV-1. A protein associated with this activity was purified from the culture supernatant of an immortalized CD8$^+$ T cell clone and identified as...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1997-10, Vol.278 (5338), p.695-698 |
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| creator | Pal, Ranajit Garzino-Demo, Alfredo Markham, Phillip D. Burns, Jennifer Brown, Michelle Gallo, Robert C. DeVico, Anthony L. |
| description | CD8$^+$ T lymphocytes from individuals infected with human immunodeficiency virus-type 1 (HIV-1) secrete a soluble activity that suppresses infection by HIV-1. A protein associated with this activity was purified from the culture supernatant of an immortalized CD8$^+$ T cell clone and identified as the β-chemokine macrophage-derived chemokine (MDC). MDC suppressed infection of CD8$^+$ cell-depleted peripheral blood mononuclear cells by primary non-syncytium-inducing and syncytium-inducing isolates of HIV-1 and the T cell line-adapted isolate HIV-1$_{IIIB}$. MDC was expressed in activated, but not resting, peripheral blood mononuclear cells and binds a receptor on activated primary T cells. These observations indicate that β-chemokines are responsible for a major proportion of HIV-1-specific suppressor activity produced by primary T cells. |
| doi_str_mv | 10.1126/science.278.5338.695 |
| format | Article |
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A protein associated with this activity was purified from the culture supernatant of an immortalized CD8$^+$ T cell clone and identified as the β-chemokine macrophage-derived chemokine (MDC). MDC suppressed infection of CD8$^+$ cell-depleted peripheral blood mononuclear cells by primary non-syncytium-inducing and syncytium-inducing isolates of HIV-1 and the T cell line-adapted isolate HIV-1$_{IIIB}$. MDC was expressed in activated, but not resting, peripheral blood mononuclear cells and binds a receptor on activated primary T cells. These observations indicate that β-chemokines are responsible for a major proportion of HIV-1-specific suppressor activity produced by primary T cells.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.278.5338.695</identifier><identifier>PMID: 9381181</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>AIDS/HIV ; Amino Acid Sequence ; Amino acids ; Antiviral Agents - immunology ; Biological and medical sciences ; Blotting, Northern ; Calcium - blood ; CD8-Positive T-Lymphocytes - immunology ; Cell Line ; Cell Line, Transformed ; Cell lines ; Cells, Cultured ; Cellular biology ; Chemokine CCL22 ; Chemokines ; Chemokines, CC - chemistry ; Chemokines, CC - immunology ; Chemokines, CC - isolation & purification ; Chemokines, CC - metabolism ; Cultured cells ; Cytokines ; Fractions ; Fundamental and applied biological sciences. Psychology ; HIV ; HIV (Viruses) ; HIV 1 ; HIV Core Protein p24 - biosynthesis ; HIV infection ; HIV infections ; HIV Infections - immunology ; HIV-1 - immunology ; HIV-1 - physiology ; Human immunodeficiency virus ; Humans ; Inactivation ; Infections ; Leukocytes, Mononuclear - immunology ; Leukocytes, Mononuclear - metabolism ; Leukocytes, Mononuclear - virology ; Lymphocyte Activation ; Microbiology ; Physiological aspects ; Prevention ; Receptors ; Receptors, Chemokine - metabolism ; Receptors, HIV - metabolism ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; RNA ; T cells ; T lymphocytes ; T-Lymphocytes - immunology ; Virology ; Virus inactivation ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1997-10, Vol.278 (5338), p.695-698</ispartof><rights>Copyright 1997 American Association for the Advancement of Science</rights><rights>1998 INIST-CNRS</rights><rights>COPYRIGHT 1997 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1997 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Oct 24, 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c686t-a4c5458b48b264abf4f331436bdab401ab7b276f0135aa696e67f8c9f0c841613</citedby><cites>FETCH-LOGICAL-c686t-a4c5458b48b264abf4f331436bdab401ab7b276f0135aa696e67f8c9f0c841613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2901176$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2901176$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2055100$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9381181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pal, Ranajit</creatorcontrib><creatorcontrib>Garzino-Demo, Alfredo</creatorcontrib><creatorcontrib>Markham, Phillip D.</creatorcontrib><creatorcontrib>Burns, Jennifer</creatorcontrib><creatorcontrib>Brown, Michelle</creatorcontrib><creatorcontrib>Gallo, Robert C.</creatorcontrib><creatorcontrib>DeVico, Anthony L.</creatorcontrib><title>Inhibition of HIV-1 Infection by the β-Chemokine MDC</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>CD8$^+$ T lymphocytes from individuals infected with human immunodeficiency virus-type 1 (HIV-1) secrete a soluble activity that suppresses infection by HIV-1. A protein associated with this activity was purified from the culture supernatant of an immortalized CD8$^+$ T cell clone and identified as the β-chemokine macrophage-derived chemokine (MDC). MDC suppressed infection of CD8$^+$ cell-depleted peripheral blood mononuclear cells by primary non-syncytium-inducing and syncytium-inducing isolates of HIV-1 and the T cell line-adapted isolate HIV-1$_{IIIB}$. MDC was expressed in activated, but not resting, peripheral blood mononuclear cells and binds a receptor on activated primary T cells. These observations indicate that β-chemokines are responsible for a major proportion of HIV-1-specific suppressor activity produced by primary T cells.</description><subject>AIDS/HIV</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Antiviral Agents - immunology</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Calcium - blood</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cell Line</subject><subject>Cell Line, Transformed</subject><subject>Cell lines</subject><subject>Cells, Cultured</subject><subject>Cellular biology</subject><subject>Chemokine CCL22</subject><subject>Chemokines</subject><subject>Chemokines, CC - chemistry</subject><subject>Chemokines, CC - immunology</subject><subject>Chemokines, CC - isolation & purification</subject><subject>Chemokines, CC - metabolism</subject><subject>Cultured cells</subject><subject>Cytokines</subject><subject>Fractions</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>HIV (Viruses)</subject><subject>HIV 1</subject><subject>HIV Core Protein p24 - biosynthesis</subject><subject>HIV infection</subject><subject>HIV infections</subject><subject>HIV Infections - immunology</subject><subject>HIV-1 - immunology</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Inactivation</subject><subject>Infections</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Leukocytes, Mononuclear - virology</subject><subject>Lymphocyte Activation</subject><subject>Microbiology</subject><subject>Physiological aspects</subject><subject>Prevention</subject><subject>Receptors</subject><subject>Receptors, Chemokine - metabolism</subject><subject>Receptors, HIV - metabolism</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>RNA</subject><subject>T cells</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>Virology</subject><subject>Virus inactivation</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN001uEzEYBmALgUoI3KBII1QBi06wx__LEiCNFMgC6NbyOHbiMLHLeCK11-pBOBNOExUFRRB5Ycnf4z_5NQCnCA4Qqti7ZLwNxg4qLgYUYzFgkj4CPQQlLWUF8WPQgxCzUkBOn4JnKS0hzDWJT8CJxAIhgXqAjsPC177zMRTRFZfjqxIV4-CsuR-qb4tuYYtfd-VwYVfxhw-2-Pxh-Bw8cbpJ9sWu74Pvnz5-G16Wk-loPLyYlIYJ1pWaGEqoqImoK0Z07YjDGBHM6pmuCUS65nXFmYMIU62ZZJZxJ4x00AiCGMJ98Hq77nUbf65t6tTKJ2ObRgcb10nx-3sQmeGbf0OCOZSSV_9dErGqkkSIDF_9BZdx3YZ8XVXl83JO0Wbf8y2a68YqH1zsWm3mNthWNzFY5_PwBco7Z73h5QGe28yuvDnk3-75TDp70831OiU1_vrlaDq9Opq-Hx1LxWiyR88PURObxs6tyrkYTvc42XLTxpRa69R161e6vVUIqk2-1S7fKudbbfKtcr7ztJe7V1nXKzt7mLQLdK6f7eo6Gd24Vgfj0wOrIKUo_4o-ON2yZepi-6csIUKc4d9_MAXc</recordid><startdate>19971024</startdate><enddate>19971024</enddate><creator>Pal, Ranajit</creator><creator>Garzino-Demo, Alfredo</creator><creator>Markham, Phillip D.</creator><creator>Burns, Jennifer</creator><creator>Brown, Michelle</creator><creator>Gallo, Robert C.</creator><creator>DeVico, Anthony L.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>19971024</creationdate><title>Inhibition of HIV-1 Infection by the β-Chemokine MDC</title><author>Pal, Ranajit ; Garzino-Demo, Alfredo ; Markham, Phillip D. ; Burns, Jennifer ; Brown, Michelle ; Gallo, Robert C. ; DeVico, Anthony L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c686t-a4c5458b48b264abf4f331436bdab401ab7b276f0135aa696e67f8c9f0c841613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>AIDS/HIV</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Antiviral Agents - immunology</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Calcium - blood</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cell Line</topic><topic>Cell Line, Transformed</topic><topic>Cell lines</topic><topic>Cells, Cultured</topic><topic>Cellular biology</topic><topic>Chemokine CCL22</topic><topic>Chemokines</topic><topic>Chemokines, CC - chemistry</topic><topic>Chemokines, CC - immunology</topic><topic>Chemokines, CC - isolation & purification</topic><topic>Chemokines, CC - metabolism</topic><topic>Cultured cells</topic><topic>Cytokines</topic><topic>Fractions</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV</topic><topic>HIV (Viruses)</topic><topic>HIV 1</topic><topic>HIV Core Protein p24 - biosynthesis</topic><topic>HIV infection</topic><topic>HIV infections</topic><topic>HIV Infections - immunology</topic><topic>HIV-1 - immunology</topic><topic>HIV-1 - physiology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Inactivation</topic><topic>Infections</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Leukocytes, Mononuclear - virology</topic><topic>Lymphocyte Activation</topic><topic>Microbiology</topic><topic>Physiological aspects</topic><topic>Prevention</topic><topic>Receptors</topic><topic>Receptors, Chemokine - metabolism</topic><topic>Receptors, HIV - metabolism</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>RNA</topic><topic>T cells</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - 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secrete a soluble activity that suppresses infection by HIV-1. A protein associated with this activity was purified from the culture supernatant of an immortalized CD8$^+$ T cell clone and identified as the β-chemokine macrophage-derived chemokine (MDC). MDC suppressed infection of CD8$^+$ cell-depleted peripheral blood mononuclear cells by primary non-syncytium-inducing and syncytium-inducing isolates of HIV-1 and the T cell line-adapted isolate HIV-1$_{IIIB}$. MDC was expressed in activated, but not resting, peripheral blood mononuclear cells and binds a receptor on activated primary T cells. These observations indicate that β-chemokines are responsible for a major proportion of HIV-1-specific suppressor activity produced by primary T cells.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>9381181</pmid><doi>10.1126/science.278.5338.695</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1997-10, Vol.278 (5338), p.695-698 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79381149 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | AIDS/HIV Amino Acid Sequence Amino acids Antiviral Agents - immunology Biological and medical sciences Blotting, Northern Calcium - blood CD8-Positive T-Lymphocytes - immunology Cell Line Cell Line, Transformed Cell lines Cells, Cultured Cellular biology Chemokine CCL22 Chemokines Chemokines, CC - chemistry Chemokines, CC - immunology Chemokines, CC - isolation & purification Chemokines, CC - metabolism Cultured cells Cytokines Fractions Fundamental and applied biological sciences. Psychology HIV HIV (Viruses) HIV 1 HIV Core Protein p24 - biosynthesis HIV infection HIV infections HIV Infections - immunology HIV-1 - immunology HIV-1 - physiology Human immunodeficiency virus Humans Inactivation Infections Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - virology Lymphocyte Activation Microbiology Physiological aspects Prevention Receptors Receptors, Chemokine - metabolism Receptors, HIV - metabolism Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains RNA T cells T lymphocytes T-Lymphocytes - immunology Virology Virus inactivation Viruses |
| title | Inhibition of HIV-1 Infection by the β-Chemokine MDC |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T01%3A53%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inhibition%20of%20HIV-1%20Infection%20by%20the%20%CE%B2-Chemokine%20MDC&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Pal,%20Ranajit&rft.date=1997-10-24&rft.volume=278&rft.issue=5338&rft.spage=695&rft.epage=698&rft.pages=695-698&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.278.5338.695&rft_dat=%3Cgale_proqu%3EA19975199%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213577519&rft_id=info:pmid/9381181&rft_galeid=A19975199&rft_jstor_id=2901176&rfr_iscdi=true |