A Case of Fatal Hemolytic Disease of the Newborn Associated With-D-/-D-Phenotype
ABSTRACT -D- is a rare haplotype that determines D without C, c, E or e, and exalted D activity. The extremely rare homozygote propositi (-D-/-D-) are usually ascertained through their immune antibodies, anti-Rh17 (Hô), which react with red cells of all common Rh phenotypes. The authors experienced...
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| Veröffentlicht in: | American journal of perinatology 1997-09, Vol.14 (8), p.495-497 |
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| container_title | American journal of perinatology |
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| creator | Han, Kyou Sup Kim, Hee Chung Han, Kwang Soo Shim, Woo Sup |
| description | ABSTRACT
-D- is a rare haplotype that determines D without C, c, E or e, and exalted D activity. The extremely rare homozygote propositi (-D-/-D-) are usually ascertained through their immune antibodies, anti-Rh17 (Hô), which react with red cells of all common Rh phenotypes. The authors experienced the first case in Korea of a woman with -D- phenotype. She had a history of spontaneous abortion, therapeutic termination and red cell transfusion, and at her third pregnancy she delivered a baby with severe hemolytic disease of the newborn. In spite of intensive medical intervention, the baby died of hydrops fetalis. An immune antibody to high incidence Rh antigen, namely anti-Rhi 7 (Hô), was demonstrated in the woman's serum. A family study revealed that the -D- gene complex was present in all its members and one of the woman's sisters was also -D- homozygote. In the serum of this sister, anti-Rh1 7 (Hô) was also present. |
| doi_str_mv | 10.1055/s-2007-994188 |
| format | Article |
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-D- is a rare haplotype that determines D without C, c, E or e, and exalted D activity. The extremely rare homozygote propositi (-D-/-D-) are usually ascertained through their immune antibodies, anti-Rh17 (Hô), which react with red cells of all common Rh phenotypes. The authors experienced the first case in Korea of a woman with -D- phenotype. She had a history of spontaneous abortion, therapeutic termination and red cell transfusion, and at her third pregnancy she delivered a baby with severe hemolytic disease of the newborn. In spite of intensive medical intervention, the baby died of hydrops fetalis. An immune antibody to high incidence Rh antigen, namely anti-Rhi 7 (Hô), was demonstrated in the woman's serum. A family study revealed that the -D- gene complex was present in all its members and one of the woman's sisters was also -D- homozygote. In the serum of this sister, anti-Rh1 7 (Hô) was also present.</description><identifier>ISSN: 0735-1631</identifier><identifier>EISSN: 1098-8785</identifier><identifier>DOI: 10.1055/s-2007-994188</identifier><identifier>PMID: 9376014</identifier><identifier>CODEN: AJPEEK</identifier><language>eng</language><publisher>New York, NY: Thieme</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Erythroblastosis, Fetal - blood ; Erythroblastosis, Fetal - genetics ; Erythroblastosis, Fetal - immunology ; Fatal Outcome ; Female ; Haplotypes ; Humans ; Infant, Newborn ; Intensive care medicine ; Isoantibodies - analysis ; Medical sciences ; ORIGINAL ARTICLE ; Pedigree ; Phenotype ; Pregnancy ; Rh-Hr Blood-Group System - genetics</subject><ispartof>American journal of perinatology, 1997-09, Vol.14 (8), p.495-497</ispartof><rights>1997 by Thieme Medical Publishers, Inc.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-20e5882955239b261d83376fba08bd0ad9612f4e6824c1a75114082df33a7a303</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-994188.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2007-994188$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3004,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2815425$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9376014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Kyou Sup</creatorcontrib><creatorcontrib>Kim, Hee Chung</creatorcontrib><creatorcontrib>Han, Kwang Soo</creatorcontrib><creatorcontrib>Shim, Woo Sup</creatorcontrib><title>A Case of Fatal Hemolytic Disease of the Newborn Associated With-D-/-D-Phenotype</title><title>American journal of perinatology</title><addtitle>Amer J Perinatol</addtitle><description>ABSTRACT
-D- is a rare haplotype that determines D without C, c, E or e, and exalted D activity. The extremely rare homozygote propositi (-D-/-D-) are usually ascertained through their immune antibodies, anti-Rh17 (Hô), which react with red cells of all common Rh phenotypes. The authors experienced the first case in Korea of a woman with -D- phenotype. She had a history of spontaneous abortion, therapeutic termination and red cell transfusion, and at her third pregnancy she delivered a baby with severe hemolytic disease of the newborn. In spite of intensive medical intervention, the baby died of hydrops fetalis. An immune antibody to high incidence Rh antigen, namely anti-Rhi 7 (Hô), was demonstrated in the woman's serum. A family study revealed that the -D- gene complex was present in all its members and one of the woman's sisters was also -D- homozygote. In the serum of this sister, anti-Rh1 7 (Hô) was also present.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Erythroblastosis, Fetal - blood</subject><subject>Erythroblastosis, Fetal - genetics</subject><subject>Erythroblastosis, Fetal - immunology</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Intensive care medicine</subject><subject>Isoantibodies - analysis</subject><subject>Medical sciences</subject><subject>ORIGINAL ARTICLE</subject><subject>Pedigree</subject><subject>Phenotype</subject><subject>Pregnancy</subject><subject>Rh-Hr Blood-Group System - genetics</subject><issn>0735-1631</issn><issn>1098-8785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0EKqUwMiJlQEyY-hEnzli1lCJV0AHEaDnJjRKUxCV2hPrvcZWoG8PVHb6j-zgI3VLyRIkQc4sZITFOkpBKeYamlCQSy1iKczQlMReYRpxeoitrvwmhTBI5QZOExxGh4RTtFsFSWwhMEay103WwgcbUB1dlwaqyMEauhOANflPTtcHCWpNV2kEefFWuxCs897UroTXusIdrdFHo2sLN2Gfoc_38sdzg7fvL63KxxRkXofM3g5CSJUIwnqQsornk_qYi1USmOdF5ElFWhBBJFmZUx4LSkEiWF5zrWHPCZ-hhmLvvzE8P1qmmshnUtW7B9FbF_kWvhHoQD2DWGWs7KNS-qxrdHRQl6mhQWXU0qAaDnr8bB_dpA_mJHpX5_H7Mtc10XXS6zSp7wpikImTCY48D5soKGlDfpu9aL-SfrX-q-YLO</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Han, Kyou Sup</creator><creator>Kim, Hee Chung</creator><creator>Han, Kwang Soo</creator><creator>Shim, Woo Sup</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970901</creationdate><title>A Case of Fatal Hemolytic Disease of the Newborn Associated With-D-/-D-Phenotype</title><author>Han, Kyou Sup ; Kim, Hee Chung ; Han, Kwang Soo ; Shim, Woo Sup</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-20e5882955239b261d83376fba08bd0ad9612f4e6824c1a75114082df33a7a303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Erythroblastosis, Fetal - blood</topic><topic>Erythroblastosis, Fetal - genetics</topic><topic>Erythroblastosis, Fetal - immunology</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Intensive care medicine</topic><topic>Isoantibodies - analysis</topic><topic>Medical sciences</topic><topic>ORIGINAL ARTICLE</topic><topic>Pedigree</topic><topic>Phenotype</topic><topic>Pregnancy</topic><topic>Rh-Hr Blood-Group System - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Kyou Sup</creatorcontrib><creatorcontrib>Kim, Hee Chung</creatorcontrib><creatorcontrib>Han, Kwang Soo</creatorcontrib><creatorcontrib>Shim, Woo Sup</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Kyou Sup</au><au>Kim, Hee Chung</au><au>Han, Kwang Soo</au><au>Shim, Woo Sup</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case of Fatal Hemolytic Disease of the Newborn Associated With-D-/-D-Phenotype</atitle><jtitle>American journal of perinatology</jtitle><addtitle>Amer J Perinatol</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>14</volume><issue>8</issue><spage>495</spage><epage>497</epage><pages>495-497</pages><issn>0735-1631</issn><eissn>1098-8785</eissn><coden>AJPEEK</coden><abstract>ABSTRACT
-D- is a rare haplotype that determines D without C, c, E or e, and exalted D activity. The extremely rare homozygote propositi (-D-/-D-) are usually ascertained through their immune antibodies, anti-Rh17 (Hô), which react with red cells of all common Rh phenotypes. The authors experienced the first case in Korea of a woman with -D- phenotype. She had a history of spontaneous abortion, therapeutic termination and red cell transfusion, and at her third pregnancy she delivered a baby with severe hemolytic disease of the newborn. In spite of intensive medical intervention, the baby died of hydrops fetalis. An immune antibody to high incidence Rh antigen, namely anti-Rhi 7 (Hô), was demonstrated in the woman's serum. A family study revealed that the -D- gene complex was present in all its members and one of the woman's sisters was also -D- homozygote. In the serum of this sister, anti-Rh1 7 (Hô) was also present.</abstract><cop>New York, NY</cop><pub>Thieme</pub><pmid>9376014</pmid><doi>10.1055/s-2007-994188</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive care: neonates and children. Prematurity. Sudden death Erythroblastosis, Fetal - blood Erythroblastosis, Fetal - genetics Erythroblastosis, Fetal - immunology Fatal Outcome Female Haplotypes Humans Infant, Newborn Intensive care medicine Isoantibodies - analysis Medical sciences ORIGINAL ARTICLE Pedigree Phenotype Pregnancy Rh-Hr Blood-Group System - genetics |
| title | A Case of Fatal Hemolytic Disease of the Newborn Associated With-D-/-D-Phenotype |
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