The cytosolic phosphoprotein stathmin is expressed in the olfactory system of the adult rat
STATHMIN is a cytosolic protein expressed particularly in the developing nervous system, whose phosphorylation is correlated with the action of multiple extracellular stimuli regulating cell proliferation and differentiation. In this study, we used an antibody that specifically recognizes the carbox...
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| Veröffentlicht in: | Neuroreport 1997-09, Vol.8 (13), p.2825-2829 |
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| container_issue | 13 |
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| container_title | Neuroreport |
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| creator | Camoletto, Paola Peretto, Paolo Bonfanti, Luca Manceau, Valérie Sobel, André Fasolo, Aldo |
| description | STATHMIN is a cytosolic protein expressed particularly in the developing nervous system, whose phosphorylation is correlated with the action of multiple extracellular stimuli regulating cell proliferation and differentiation. In this study, we used an antibody that specifically recognizes the carboxyterminal region of stathmin to analyze the distribution of this protein in the olfactory system of adult rats, and found a high and selective immunoreactivity in immature olfactory receptors of the olfactory neuroepithelium and in cells of the rostral migratory stream. These results reveal an expression of stathmin in regions of the adult nervous system characterized by striking structural plasticity and cell renewal, suggesting that this protein could play a role in the differentiation of newly generated cell populations. |
| doi_str_mv | 10.1097/00001756-199709080-00004 |
| format | Article |
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Gustatory system and gustation</topic><topic>Phosphoproteins - analysis</topic><topic>Prosencephalon - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stathmin</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Camoletto, Paola</creatorcontrib><creatorcontrib>Peretto, Paolo</creatorcontrib><creatorcontrib>Bonfanti, Luca</creatorcontrib><creatorcontrib>Manceau, Valérie</creatorcontrib><creatorcontrib>Sobel, André</creatorcontrib><creatorcontrib>Fasolo, Aldo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Camoletto, Paola</au><au>Peretto, Paolo</au><au>Bonfanti, Luca</au><au>Manceau, Valérie</au><au>Sobel, André</au><au>Fasolo, Aldo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The cytosolic phosphoprotein stathmin is expressed in the olfactory system of the adult rat</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1997-09-08</date><risdate>1997</risdate><volume>8</volume><issue>13</issue><spage>2825</spage><epage>2829</epage><pages>2825-2829</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>STATHMIN is a cytosolic protein expressed particularly in the developing nervous system, whose phosphorylation is correlated with the action of multiple extracellular stimuli regulating cell proliferation and differentiation. In this study, we used an antibody that specifically recognizes the carboxyterminal region of stathmin to analyze the distribution of this protein in the olfactory system of adult rats, and found a high and selective immunoreactivity in immature olfactory receptors of the olfactory neuroepithelium and in cells of the rostral migratory stream. These results reveal an expression of stathmin in regions of the adult nervous system characterized by striking structural plasticity and cell renewal, suggesting that this protein could play a role in the differentiation of newly generated cell populations.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9376512</pmid><doi>10.1097/00001756-199709080-00004</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroreport, 1997-09, Vol.8 (13), p.2825-2829 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Brain Mapping - methods Cytosol - chemistry Fundamental and applied biological sciences. Psychology Immunohistochemistry Microtubule Proteins Nerve Tissue Proteins - analysis Olfactory Bulb - chemistry Olfactory Mucosa - chemistry Olfactory Pathways - chemistry Olfactory system and olfaction. Gustatory system and gustation Phosphoproteins - analysis Prosencephalon - chemistry Rats Rats, Wistar Stathmin Vertebrates: nervous system and sense organs |
| title | The cytosolic phosphoprotein stathmin is expressed in the olfactory system of the adult rat |
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