A follow-up study of vesico-ureteric reflux and renal scars in asymptomatic siblings of children with reflux
The objectives of this study were to follow up children with vesico-ureteric reflux (VUR) and renal scars, to evaluate kidney growth and to determine the incidence of urinary tract infection (UTI) and elevated blood pressure in 40 asymptomatic siblings of children with VUR, in whom VUR had been dete...
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| Veröffentlicht in: | Nuclear medicine communications 1997-09, Vol.18 (9), p.827-831 |
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| container_title | Nuclear medicine communications |
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| creator | KENDA, R B ZUPANCIC, Z FETTICH, J J MEGLIC, A |
| description | The objectives of this study were to follow up children with vesico-ureteric reflux (VUR) and renal scars, to evaluate kidney growth and to determine the incidence of urinary tract infection (UTI) and elevated blood pressure in 40 asymptomatic siblings of children with VUR, in whom VUR had been detected at an early age, and to gather additional data which could help to evaluate the need for screening for VUR in asymptomatic siblings. During the follow-up period of 3–7 years, two children (5%) had UTI; 66% of VUR grade 1 and 2 disappeared. The progression of scars was only detected in two of nine children with renal scars on the initial study, both of whom had high-grade VUR. Renal ultrasound was normal in all siblings and none developed hypertension. The results indicate that low-grade sterile VUR may not play a major role in renal scarring, but this may not be the case with high-grade sterile VUR. Considering the correlations among VUR, UTI and reflux nephropathy, routine screening for VUR at an early age in asymptomatic siblings of children with VUR seems to be justified to identify those at the greatest risk of subsequent renal damage. |
| doi_str_mv | 10.1097/00006231-199709000-00005 |
| format | Article |
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During the follow-up period of 3–7 years, two children (5%) had UTI; 66% of VUR grade 1 and 2 disappeared. The progression of scars was only detected in two of nine children with renal scars on the initial study, both of whom had high-grade VUR. Renal ultrasound was normal in all siblings and none developed hypertension. The results indicate that low-grade sterile VUR may not play a major role in renal scarring, but this may not be the case with high-grade sterile VUR. Considering the correlations among VUR, UTI and reflux nephropathy, routine screening for VUR at an early age in asymptomatic siblings of children with VUR seems to be justified to identify those at the greatest risk of subsequent renal damage.</description><identifier>ISSN: 0143-3636</identifier><identifier>EISSN: 1473-5628</identifier><identifier>DOI: 10.1097/00006231-199709000-00005</identifier><identifier>PMID: 9352548</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Biological and medical sciences ; Child ; Child, Preschool ; Cicatrix - diagnostic imaging ; Family ; Female ; Follow-Up Studies ; Humans ; Infant ; Kidney - diagnostic imaging ; Kidney - pathology ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Radionuclide Imaging ; Risk Factors ; Ultrasonography ; Urinary system involvement in other diseases. Miscellaneous ; Urinary Tract Infections - complications ; Urinary tract. Prostate gland ; Vesico-Ureteral Reflux - complications ; Vesico-Ureteral Reflux - diagnostic imaging ; Vesico-Ureteral Reflux - genetics</subject><ispartof>Nuclear medicine communications, 1997-09, Vol.18 (9), p.827-831</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3845-2b030615651284c638bb897ec72a4b5cf67565354e3907de9a50f708bb0686593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2836500$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9352548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KENDA, R B</creatorcontrib><creatorcontrib>ZUPANCIC, Z</creatorcontrib><creatorcontrib>FETTICH, J J</creatorcontrib><creatorcontrib>MEGLIC, A</creatorcontrib><title>A follow-up study of vesico-ureteric reflux and renal scars in asymptomatic siblings of children with reflux</title><title>Nuclear medicine communications</title><addtitle>Nucl Med Commun</addtitle><description>The objectives of this study were to follow up children with vesico-ureteric reflux (VUR) and renal scars, to evaluate kidney growth and to determine the incidence of urinary tract infection (UTI) and elevated blood pressure in 40 asymptomatic siblings of children with VUR, in whom VUR had been detected at an early age, and to gather additional data which could help to evaluate the need for screening for VUR in asymptomatic siblings. During the follow-up period of 3–7 years, two children (5%) had UTI; 66% of VUR grade 1 and 2 disappeared. The progression of scars was only detected in two of nine children with renal scars on the initial study, both of whom had high-grade VUR. Renal ultrasound was normal in all siblings and none developed hypertension. The results indicate that low-grade sterile VUR may not play a major role in renal scarring, but this may not be the case with high-grade sterile VUR. Considering the correlations among VUR, UTI and reflux nephropathy, routine screening for VUR at an early age in asymptomatic siblings of children with VUR seems to be justified to identify those at the greatest risk of subsequent renal damage.</description><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cicatrix - diagnostic imaging</subject><subject>Family</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Radionuclide Imaging</subject><subject>Risk Factors</subject><subject>Ultrasonography</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary Tract Infections - complications</subject><subject>Urinary tract. Prostate gland</subject><subject>Vesico-Ureteral Reflux - complications</subject><subject>Vesico-Ureteral Reflux - diagnostic imaging</subject><subject>Vesico-Ureteral Reflux - genetics</subject><issn>0143-3636</issn><issn>1473-5628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV9vFCEUxYmpadfqRzDhwfQNhWH499g0rZo08UWfCcMwLsoMW-6M6377su64b-UFuOd3D-RchDCjHxk16hOtSzacEWaMoqbeyLEkXqENaxUnQjb6Am0oaznhkssr9AbgVyU0l-oSXRouGtHqDUq3eMgp5T1ZdhjmpT_gPOA_AaLPZClhDiV6XMKQlr_YTX09Ti5h8K4AjhN2cBh3cx7dXDGIXYrTTzha-G1MfYXxPs7b1eAtej24BOHdul-jHw_33---kMdvn7_e3T4Sz3UrSNNRTiUTUrBGt15y3XXaqOBV49pO-EGqqnHRBm6o6oNxgg6KVopKLYXh1-jm5Lsr-WkJMNsxgg8puSnkBawyXGmheAX1CfQlA9RP2l2JoysHy6g9Bm3_B23PQf8ridr6fn1j6cbQnxvXZKv-YdVdDSsNxU0-whlr6iAEpRVrT9g-p5o1_E7LPhS7DS7NW_vSmPkzqXaU9g</recordid><startdate>199709</startdate><enddate>199709</enddate><creator>KENDA, R B</creator><creator>ZUPANCIC, Z</creator><creator>FETTICH, J J</creator><creator>MEGLIC, A</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199709</creationdate><title>A follow-up study of vesico-ureteric reflux and renal scars in asymptomatic siblings of children with reflux</title><author>KENDA, R B ; ZUPANCIC, Z ; FETTICH, J J ; MEGLIC, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3845-2b030615651284c638bb897ec72a4b5cf67565354e3907de9a50f708bb0686593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cicatrix - diagnostic imaging</topic><topic>Family</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Radionuclide Imaging</topic><topic>Risk Factors</topic><topic>Ultrasonography</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary Tract Infections - complications</topic><topic>Urinary tract. Prostate gland</topic><topic>Vesico-Ureteral Reflux - complications</topic><topic>Vesico-Ureteral Reflux - diagnostic imaging</topic><topic>Vesico-Ureteral Reflux - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KENDA, R B</creatorcontrib><creatorcontrib>ZUPANCIC, Z</creatorcontrib><creatorcontrib>FETTICH, J J</creatorcontrib><creatorcontrib>MEGLIC, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KENDA, R B</au><au>ZUPANCIC, Z</au><au>FETTICH, J J</au><au>MEGLIC, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A follow-up study of vesico-ureteric reflux and renal scars in asymptomatic siblings of children with reflux</atitle><jtitle>Nuclear medicine communications</jtitle><addtitle>Nucl Med Commun</addtitle><date>1997-09</date><risdate>1997</risdate><volume>18</volume><issue>9</issue><spage>827</spage><epage>831</epage><pages>827-831</pages><issn>0143-3636</issn><eissn>1473-5628</eissn><abstract>The objectives of this study were to follow up children with vesico-ureteric reflux (VUR) and renal scars, to evaluate kidney growth and to determine the incidence of urinary tract infection (UTI) and elevated blood pressure in 40 asymptomatic siblings of children with VUR, in whom VUR had been detected at an early age, and to gather additional data which could help to evaluate the need for screening for VUR in asymptomatic siblings. During the follow-up period of 3–7 years, two children (5%) had UTI; 66% of VUR grade 1 and 2 disappeared. The progression of scars was only detected in two of nine children with renal scars on the initial study, both of whom had high-grade VUR. Renal ultrasound was normal in all siblings and none developed hypertension. The results indicate that low-grade sterile VUR may not play a major role in renal scarring, but this may not be the case with high-grade sterile VUR. Considering the correlations among VUR, UTI and reflux nephropathy, routine screening for VUR at an early age in asymptomatic siblings of children with VUR seems to be justified to identify those at the greatest risk of subsequent renal damage.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9352548</pmid><doi>10.1097/00006231-199709000-00005</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0143-3636 |
| ispartof | Nuclear medicine communications, 1997-09, Vol.18 (9), p.827-831 |
| issn | 0143-3636 1473-5628 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences Child Child, Preschool Cicatrix - diagnostic imaging Family Female Follow-Up Studies Humans Infant Kidney - diagnostic imaging Kidney - pathology Male Medical sciences Nephrology. Urinary tract diseases Radionuclide Imaging Risk Factors Ultrasonography Urinary system involvement in other diseases. Miscellaneous Urinary Tract Infections - complications Urinary tract. Prostate gland Vesico-Ureteral Reflux - complications Vesico-Ureteral Reflux - diagnostic imaging Vesico-Ureteral Reflux - genetics |
| title | A follow-up study of vesico-ureteric reflux and renal scars in asymptomatic siblings of children with reflux |
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