Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase

The epidermal growth factor receptor (EGFR) is overexpressed in a significant percentage of carcinomas and contributes to the malignant phenotype. CP-358,774 is a directly acting inhibitor of human EGFR tyrosine kinase with an IC50 of 2 nM and reduces EGFR autophosphorylation in intact tumor cells w...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-11, Vol.57 (21), p.4838-4848
Hauptverfasser:	MOYER, J. D, BARBACCI, E. G, NEVEU, M, POLLACK, V. A, PUSTILNIK, L. R, REYNOLDS, M. M, SLOAN, D, THELEMAN, A, MILLER, P, IWATA, K. K, ARNOLD, L, BOMAN, B, CUNNINGHAM, A, DIORIO, C, DOTY, J, MORIN, M. J, MOYER, M. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Antineoplastic agents Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Cell Cycle - drug effects Cell Cycle - genetics Cell Division - drug effects DNA Fragmentation DNA, Neoplasm - drug effects Enzyme Inhibitors - pharmacology Epidermal Growth Factor - metabolism General aspects Humans Medical sciences Mice Mice, Nude Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Pharmacology. Drug treatments Phosphorylation - drug effects Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Retinoblastoma Protein - metabolism Tumor Cells, Cultured
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