$Conserved Repetitive Epitope Recognized by CD4$^{+}$ Clones from a Malaria-Immunized Volunteer$

Conserved Repetitive Epitope Recognized by CD4$^{+}$ Clones from a Malaria-Immunized Volunteer

T cell clones obtained from a human volunteer immunized with Plasmodium falciparum sporozoites specifically recognized the native circumsporozoite (CS) antigen expressed on P. falciparum sporozoites, as well as bacteria- and yeast-derived recombinant falciparum CS proteins. The response of these CD4...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1989-12, Vol.246 (4937), p.1603-1606
Hauptverfasser:	Nardin, Elizabeth H., Herrington, Deirdre A., Davis, Jonathan, Levine, Myron, Stuber, Dietrich, Takacs, Bela, Caspers, Patrick, Barr, Philip, Altszuler, Rita, Clavijo, Pedro, Nussenzweig, Ruth S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Antigenic determinants, haptens, artificial antigens Antigens Antigens, Protozoan - immunology Biological and medical sciences CD4 Antigens - immunology Cells, Cultured Clone Cells Epitopes Epitopes - analysis Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Interferon-gamma - biosynthesis Lymphocyte Activation Lymphocytes Malaria Malaria - immunology Malaria vaccine Malaria vaccines Medical research Molecular immunology Molecular Sequence Data Neutrophils Physiological aspects Plasmodium falciparum Plasmodium falciparum - immunology Protozoan diseases Protozoan Proteins Recombinant proteins Recombinant Proteins - immunology Sporozoites T cells T lymphocytes T-Lymphocytes - immunology Volunteerism
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