Involvement of noradrenergic system in a remarkably rapid tongue clonus produced by acute hypnotic doses of ethanol in Fischer F344 rats
Ethanol (2.95 g/kg, IP) eliminated the righting reflex and induced vigorous tongue clonus spontaneously or following tactile tongue stimulation in Fischer F344 rats. Responses normally lasted 30-60 min, and was reinstated by tactile stimulation in those cases where it subsided quickly. Sub-hypnotic...
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| Veröffentlicht in: | Psychopharmacologia 1989-01, Vol.99 (4), p.497-500 |
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| container_title | Psychopharmacologia |
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| creator | MENON, M. K LLOYD, R. L |
| description | Ethanol (2.95 g/kg, IP) eliminated the righting reflex and induced vigorous tongue clonus spontaneously or following tactile tongue stimulation in Fischer F344 rats. Responses normally lasted 30-60 min, and was reinstated by tactile stimulation in those cases where it subsided quickly. Sub-hypnotic (1.95 g/kg) or high (3.95 g/kg) doses failed to elicit clonus, even after tactile stimulation. A lipophilic alpha 1-adrenergic agonist (St 587) promptly initiated tongue clonus in rats treated with a 3.95 g/kg dose of ethanol. Prazosin, a selective alpha 1-adrenergic antagonist, blocked clonus, while the dopamine selective antagonist pimozide failed to modify this response. We infer an alpha 1-adrenergic effect in which norepinephrine is released by ethanol. |
| doi_str_mv | 10.1007/BF00589898 |
| format | Article |
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We infer an alpha 1-adrenergic effect in which norepinephrine is released by ethanol.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/BF00589898</identifier><identifier>PMID: 2594916</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Alcoholism and acute alcohol poisoning ; Animals ; Biological and medical sciences ; Brain Chemistry - drug effects ; Clonidine - analogs & derivatives ; Clonidine - pharmacology ; Ethanol - pharmacology ; Hypnotics and Sedatives - pharmacology ; Male ; Medical sciences ; Muscles - drug effects ; Norepinephrine - physiology ; Pimozide - pharmacology ; Prazosin - pharmacology ; Rats ; Rats, Inbred F344 ; Rats, Inbred Strains ; Tongue - drug effects ; Toxicology</subject><ispartof>Psychopharmacologia, 1989-01, Vol.99 (4), p.497-500</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-643e411e49d63f57b5991215eb8ed67919d5c18256b91436e9b519ad4fab41fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6662670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2594916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MENON, M. K</creatorcontrib><creatorcontrib>LLOYD, R. L</creatorcontrib><title>Involvement of noradrenergic system in a remarkably rapid tongue clonus produced by acute hypnotic doses of ethanol in Fischer F344 rats</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>Ethanol (2.95 g/kg, IP) eliminated the righting reflex and induced vigorous tongue clonus spontaneously or following tactile tongue stimulation in Fischer F344 rats. Responses normally lasted 30-60 min, and was reinstated by tactile stimulation in those cases where it subsided quickly. Sub-hypnotic (1.95 g/kg) or high (3.95 g/kg) doses failed to elicit clonus, even after tactile stimulation. A lipophilic alpha 1-adrenergic agonist (St 587) promptly initiated tongue clonus in rats treated with a 3.95 g/kg dose of ethanol. Prazosin, a selective alpha 1-adrenergic antagonist, blocked clonus, while the dopamine selective antagonist pimozide failed to modify this response. We infer an alpha 1-adrenergic effect in which norepinephrine is released by ethanol.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - drug effects</subject><subject>Clonidine - analogs & derivatives</subject><subject>Clonidine - pharmacology</subject><subject>Ethanol - pharmacology</subject><subject>Hypnotics and Sedatives - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscles - drug effects</subject><subject>Norepinephrine - physiology</subject><subject>Pimozide - pharmacology</subject><subject>Prazosin - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Inbred Strains</subject><subject>Tongue - drug effects</subject><subject>Toxicology</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1P3DAQQC1URLfbXrhX8qHiUCnF34mPgFiKhMSFniPHnrBpE3uxnZXyD_jZ9YoVeA4-zNPT6CF0TskvSkh9eb0hRDa6zAlaUcFZxUjNPqEVIZxXnMrmM_qS0l9SnmjEGTpjUgtN1Qq93vt9GPcwgc849NiHaFwED_F5sDgtKcOEB48NjjCZ-M9044Kj2Q0O5-CfZ8B2DH5OeBeDmy043C3Y2DkD3i47H3KxuJAgHeSQt8aH8eDbDMluIeINF6L4cvqKTnszJvh2_Nfoz-b26eZ39fB4d39z9VBZVpNcKcFBUApCO8V7WXdSa8qohK4Bp2pNtZOWNkyqTpcSCnQnqTZO9KYTtAe-Rhdv3nLwywwpt1M5BcbReAhzamvNa8kaXcCfb6CNIaUIfbuLQ0mwtJS0h-ztR_YCfz9a524C944eO5f9j-PeJGvGPhpvh_SOKaWYqgn_DwXCip4</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>MENON, M. 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L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-643e411e49d63f57b5991215eb8ed67919d5c18256b91436e9b519ad4fab41fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry - drug effects</topic><topic>Clonidine - analogs & derivatives</topic><topic>Clonidine - pharmacology</topic><topic>Ethanol - pharmacology</topic><topic>Hypnotics and Sedatives - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscles - drug effects</topic><topic>Norepinephrine - physiology</topic><topic>Pimozide - pharmacology</topic><topic>Prazosin - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rats, Inbred Strains</topic><topic>Tongue - drug effects</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MENON, M. K</creatorcontrib><creatorcontrib>LLOYD, R. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MENON, M. K</au><au>LLOYD, R. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of noradrenergic system in a remarkably rapid tongue clonus produced by acute hypnotic doses of ethanol in Fischer F344 rats</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>1989-01-01</date><risdate>1989</risdate><volume>99</volume><issue>4</issue><spage>497</spage><epage>500</epage><pages>497-500</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>Ethanol (2.95 g/kg, IP) eliminated the righting reflex and induced vigorous tongue clonus spontaneously or following tactile tongue stimulation in Fischer F344 rats. Responses normally lasted 30-60 min, and was reinstated by tactile stimulation in those cases where it subsided quickly. Sub-hypnotic (1.95 g/kg) or high (3.95 g/kg) doses failed to elicit clonus, even after tactile stimulation. A lipophilic alpha 1-adrenergic agonist (St 587) promptly initiated tongue clonus in rats treated with a 3.95 g/kg dose of ethanol. Prazosin, a selective alpha 1-adrenergic antagonist, blocked clonus, while the dopamine selective antagonist pimozide failed to modify this response. We infer an alpha 1-adrenergic effect in which norepinephrine is released by ethanol.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2594916</pmid><doi>10.1007/BF00589898</doi><tpages>4</tpages></addata></record> |
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| ispartof | Psychopharmacologia, 1989-01, Vol.99 (4), p.497-500 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Brain Chemistry - drug effects Clonidine - analogs & derivatives Clonidine - pharmacology Ethanol - pharmacology Hypnotics and Sedatives - pharmacology Male Medical sciences Muscles - drug effects Norepinephrine - physiology Pimozide - pharmacology Prazosin - pharmacology Rats Rats, Inbred F344 Rats, Inbred Strains Tongue - drug effects Toxicology |
| title | Involvement of noradrenergic system in a remarkably rapid tongue clonus produced by acute hypnotic doses of ethanol in Fischer F344 rats |
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