Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats
Learning/memory deficits in senescent animals are widely used as a tool to evaluate the therapeutic potential of agents for treatment of age-associated cognitive dysfunction. As assessed in the Morris water maze test, aged (21-24 months) rats showed a variable loss of spatial memory. Aged non-impair...
Gespeichert in:
| Veröffentlicht in: | Psychopharmacologia 1989-11, Vol.99 (3), p.316-321 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 321 |
|---|---|
| container_issue | 3 |
| container_start_page | 316 |
| container_title | Psychopharmacologia |
| container_volume | 99 |
| creator | ZANOTTI, A VALZELLI, L TOFFANO, G |
| description | Learning/memory deficits in senescent animals are widely used as a tool to evaluate the therapeutic potential of agents for treatment of age-associated cognitive dysfunction. As assessed in the Morris water maze test, aged (21-24 months) rats showed a variable loss of spatial memory. Aged non-impaired rats performed as well as young subjects, while aged impaired rats exhibited a severe and persistent place-navigation deficit. Passive avoidance retention was similarly affected in the two aged subpopulations. Chronic oral administration of phosphatidylserine (50 mg/kg/day for up to 12 weeks), a pharmacologically active phospholipid, was found to improve both the spatial memory and the passive avoidance retention of aged impaired rats. Results are discussed with reference to the phosphatidylserine-induced improvement of age-associated deterioration of brain functions in rats. |
| doi_str_mv | 10.1007/bf00445550 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79374117</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79374117</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-b7a2e96f4794f5ae8262f3dbe967ea1a157d18e06208c3f987212adffeaf22f13</originalsourceid><addsrcrecordid>eNo9kM1Lw0AQxRdRaq1evAt7EA9CdL-STY5arAoFL3oOk-ysXcmXu2mh_70rjc5lYN6Px7xHyCVnd5wxfV9ZxpRK05QdkTlXUiSCaXFM5oxJmUie5qfkLIQvFkflakZmIi1UXhRzUi43vu9cTYdNH4YNjM7sm4DedUhHjzC22I3UtYPvdxhoGCIBDW2x7f2eQmfoACG4HVLY9c5AVyN1HYVPNNTDGM7JiYVoeDHtBflYPb0vX5L12_Pr8mGd1FLrMak0CCwyq3ShbAqYi0xYaap40wgceKoNz5FlguW1tEWuBRdgrEWwQlguF-Tm4Bsf_d5iGMvWhRqbBjrst6HUhdSKcx3B2wNY-z4Ej7YcvGvB70vOyt82y8fVX5sRvppct1WL5h-d6ov69aRDqKGxPuZ34R_LMh4xJX8AA_p9vQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79374117</pqid></control><display><type>article</type><title>Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>ZANOTTI, A ; VALZELLI, L ; TOFFANO, G</creator><creatorcontrib>ZANOTTI, A ; VALZELLI, L ; TOFFANO, G</creatorcontrib><description>Learning/memory deficits in senescent animals are widely used as a tool to evaluate the therapeutic potential of agents for treatment of age-associated cognitive dysfunction. As assessed in the Morris water maze test, aged (21-24 months) rats showed a variable loss of spatial memory. Aged non-impaired rats performed as well as young subjects, while aged impaired rats exhibited a severe and persistent place-navigation deficit. Passive avoidance retention was similarly affected in the two aged subpopulations. Chronic oral administration of phosphatidylserine (50 mg/kg/day for up to 12 weeks), a pharmacologically active phospholipid, was found to improve both the spatial memory and the passive avoidance retention of aged impaired rats. Results are discussed with reference to the phosphatidylserine-induced improvement of age-associated deterioration of brain functions in rats.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/bf00445550</identifier><identifier>PMID: 2594899</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Aging - physiology ; Animals ; Avoidance Learning - drug effects ; Biological and medical sciences ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; Learning - drug effects ; Male ; Medical sciences ; Memory - drug effects ; Miscellaneous ; Motivation ; Neuropharmacology ; Pharmacology. Drug treatments ; Phosphatidylserines - metabolism ; Phosphatidylserines - pharmacology ; Rats ; Rats, Inbred Strains ; Space Perception - drug effects</subject><ispartof>Psychopharmacologia, 1989-11, Vol.99 (3), p.316-321</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-b7a2e96f4794f5ae8262f3dbe967ea1a157d18e06208c3f987212adffeaf22f13</citedby><cites>FETCH-LOGICAL-c377t-b7a2e96f4794f5ae8262f3dbe967ea1a157d18e06208c3f987212adffeaf22f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6614894$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2594899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZANOTTI, A</creatorcontrib><creatorcontrib>VALZELLI, L</creatorcontrib><creatorcontrib>TOFFANO, G</creatorcontrib><title>Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>Learning/memory deficits in senescent animals are widely used as a tool to evaluate the therapeutic potential of agents for treatment of age-associated cognitive dysfunction. As assessed in the Morris water maze test, aged (21-24 months) rats showed a variable loss of spatial memory. Aged non-impaired rats performed as well as young subjects, while aged impaired rats exhibited a severe and persistent place-navigation deficit. Passive avoidance retention was similarly affected in the two aged subpopulations. Chronic oral administration of phosphatidylserine (50 mg/kg/day for up to 12 weeks), a pharmacologically active phospholipid, was found to improve both the spatial memory and the passive avoidance retention of aged impaired rats. Results are discussed with reference to the phosphatidylserine-induced improvement of age-associated deterioration of brain functions in rats.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>Learning - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Miscellaneous</subject><subject>Motivation</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphatidylserines - metabolism</subject><subject>Phosphatidylserines - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Space Perception - drug effects</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1Lw0AQxRdRaq1evAt7EA9CdL-STY5arAoFL3oOk-ysXcmXu2mh_70rjc5lYN6Px7xHyCVnd5wxfV9ZxpRK05QdkTlXUiSCaXFM5oxJmUie5qfkLIQvFkflakZmIi1UXhRzUi43vu9cTYdNH4YNjM7sm4DedUhHjzC22I3UtYPvdxhoGCIBDW2x7f2eQmfoACG4HVLY9c5AVyN1HYVPNNTDGM7JiYVoeDHtBflYPb0vX5L12_Pr8mGd1FLrMak0CCwyq3ShbAqYi0xYaap40wgceKoNz5FlguW1tEWuBRdgrEWwQlguF-Tm4Bsf_d5iGMvWhRqbBjrst6HUhdSKcx3B2wNY-z4Ej7YcvGvB70vOyt82y8fVX5sRvppct1WL5h-d6ov69aRDqKGxPuZ34R_LMh4xJX8AA_p9vQ</recordid><startdate>198911</startdate><enddate>198911</enddate><creator>ZANOTTI, A</creator><creator>VALZELLI, L</creator><creator>TOFFANO, G</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198911</creationdate><title>Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats</title><author>ZANOTTI, A ; VALZELLI, L ; TOFFANO, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-b7a2e96f4794f5ae8262f3dbe967ea1a157d18e06208c3f987212adffeaf22f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>Avoidance Learning - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - metabolism</topic><topic>Learning - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Miscellaneous</topic><topic>Motivation</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphatidylserines - metabolism</topic><topic>Phosphatidylserines - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Space Perception - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZANOTTI, A</creatorcontrib><creatorcontrib>VALZELLI, L</creatorcontrib><creatorcontrib>TOFFANO, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZANOTTI, A</au><au>VALZELLI, L</au><au>TOFFANO, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>1989-11</date><risdate>1989</risdate><volume>99</volume><issue>3</issue><spage>316</spage><epage>321</epage><pages>316-321</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>Learning/memory deficits in senescent animals are widely used as a tool to evaluate the therapeutic potential of agents for treatment of age-associated cognitive dysfunction. As assessed in the Morris water maze test, aged (21-24 months) rats showed a variable loss of spatial memory. Aged non-impaired rats performed as well as young subjects, while aged impaired rats exhibited a severe and persistent place-navigation deficit. Passive avoidance retention was similarly affected in the two aged subpopulations. Chronic oral administration of phosphatidylserine (50 mg/kg/day for up to 12 weeks), a pharmacologically active phospholipid, was found to improve both the spatial memory and the passive avoidance retention of aged impaired rats. Results are discussed with reference to the phosphatidylserine-induced improvement of age-associated deterioration of brain functions in rats.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2594899</pmid><doi>10.1007/bf00445550</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacologia, 1989-11, Vol.99 (3), p.316-321 |
| issn | 0033-3158 1432-2072 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79374117 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Aging - physiology Animals Avoidance Learning - drug effects Biological and medical sciences Cerebral Cortex - drug effects Cerebral Cortex - metabolism Learning - drug effects Male Medical sciences Memory - drug effects Miscellaneous Motivation Neuropharmacology Pharmacology. Drug treatments Phosphatidylserines - metabolism Phosphatidylserines - pharmacology Rats Rats, Inbred Strains Space Perception - drug effects |
| title | Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T09%3A58%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20phosphatidylserine%20treatment%20improves%20spatial%20memory%20and%20passive%20avoidance%20in%20aged%20rats&rft.jtitle=Psychopharmacologia&rft.au=ZANOTTI,%20A&rft.date=1989-11&rft.volume=99&rft.issue=3&rft.spage=316&rft.epage=321&rft.pages=316-321&rft.issn=0033-3158&rft.eissn=1432-2072&rft.coden=PSYPAG&rft_id=info:doi/10.1007/bf00445550&rft_dat=%3Cproquest_cross%3E79374117%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79374117&rft_id=info:pmid/2594899&rfr_iscdi=true |