Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells
Helicobacter pylori is a major etiological agent in gastroduodenal disorders, with the adhesion of H. pylori to gastric epithelial cells being the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in preventing H. pylori infection. We evaluated the ef...
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| Veröffentlicht in: | Journal of gastroenterology 1997-10, Vol.32 (5), p.593-597 |
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| container_issue | 5 |
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| container_title | Journal of gastroenterology |
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| creator | Hayashi, S Sugiyama, T Yachi, A Yokota, K Hirai, Y Oguma, K Fujii, N |
| description | Helicobacter pylori is a major etiological agent in gastroduodenal disorders, with the adhesion of H. pylori to gastric epithelial cells being the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in preventing H. pylori infection. We evaluated the effect of ecabet sodium, an antiulcer agent, on H. pylori adhesion to gastric epithelial cells, using our previously established enzyme-linked immunosorbent assay. The adhesion of H. pylori was significantly inhibited by ecabet sodium in a dose-dependent manner. Our studies suggest that ecabet sodium inhibits the adhesion of H. pylori to gastric epithelial cells. |
| doi_str_mv | 10.1007/bf02934107 |
| format | Article |
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| subjects | Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - therapeutic use Bacterial Adhesion - drug effects Carcinoma - pathology Diterpenes - pharmacology Diterpenes - therapeutic use Diterpenes, Abietane Dose-Response Relationship, Drug Epithelial Cells - drug effects Epithelial Cells - microbiology Epithelial Cells - pathology Gastric Mucosa - drug effects Gastric Mucosa - microbiology Gastric Mucosa - pathology Helicobacter pylori - drug effects Helicobacter pylori - physiology Humans Peptic Ulcer - pathology Stomach Neoplasms - pathology Tumor Cells, Cultured |
| title | Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells |
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