The proximity of DNA sequences in interphase cell nuclei is correlated to genomic distance and permits ordering of cosmids spanning 250 kilobase pairs

The physical distance between DNA sequences in interphase nuclei was determined using eight cosmids containing fragments of the Chinese hamster genome that span 273 kb surrounding the dihydrofolate reductase (DHFR) gene. The distance between these sequences at the molecular level has been determined...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1989-11, Vol.5 (4), p.710-717
Hauptverfasser:	Trask, Barbara, Pinkel, Dan, van den Engh, Ger
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cell Line Cosmids Cricetinae DNA - genetics DNA Probes Interphase Nucleic Acid Hybridization Restriction Mapping Tetrahydrofolate Dehydrogenase - genetics
Online-Zugang:	Volltext
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