Systemic glutathione deficiency in symptom-free hiv-seropositive individuals
To find out whether systemic glutathione deficiency is associated with human immunodeficiency virus (HIV) infection, thus contributing to the immunodeficiency state, glutathione concentrations in venous plasma and lung epithelial lining fluid (ELF) of symptom-free HIV-seropositive and normal individ...
Gespeichert in:
| Veröffentlicht in: | The Lancet (British edition) 1989-12, Vol.2 (8675), p.1294-1298 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1298 |
|---|---|
| container_issue | 8675 |
| container_start_page | 1294 |
| container_title | The Lancet (British edition) |
| container_volume | 2 |
| creator | BUHL, R ARI JAFFE, H HOLROYD, K. J WELLS, F. B MASTRANGELI, A SALTINI, C CANTIN, A. M CRYSTAL, R. G |
| description | To find out whether systemic glutathione deficiency is associated with human immunodeficiency virus (HIV) infection, thus contributing to the immunodeficiency state, glutathione concentrations in venous plasma and lung epithelial lining fluid (ELF) of symptom-free HIV-seropositive and normal individuals were measured. Total and reduced glutathione concentrations in the plasma of the HIV-infected subjects were about 30% of those in the normal individuals. Concentrations of these substances in the ELF of HIV-infected subjects were about 60% of those in the controls. There was no correlation between ELF and plasma concentrations of total or reduced glutathione. Since glutathione enhances immune function, glutathione deficiency may contribute to the progressive immune dysfunction of HIV infection. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_79368657</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79368657</sourcerecordid><originalsourceid>FETCH-LOGICAL-p168t-e11862cd0168291bad1a72475ba018a1e658061d2c54db9cda615e9a4366d7393</originalsourceid><addsrcrecordid>eNo9j0tLxDAYRYMo4zj6E4RudBfIO81SBnWEggsV3JU0-epE-rJJB_rvLVhcXS7ncOGeoS0VWmAp9Oc52hIqCFaaq0t0FeM3IUQoIjdow6QWTMotKt7mmKANLvtqpmTTMfQdZB7q4AJ0bs5Cl8W5HVLf4noEyI7hhCOM_dDHkMIJFsGHU_CTbeI1uqiXgJs1d-jj6fF9f8DF6_PL_qHAA1V5wkBprpjzZGnM0Mp6ajUTWlaW0NxSUDIninrmpPCVcd4qKsFYwZXymhu-Q_d_u8PY_0wQU9mG6KBpbAf9FEttuMqV1It4u4pT1YIvhzG0dpzL9f7C71Zuo7NNPdrOhfivUSMFU4bzX49qZQs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79368657</pqid></control><display><type>article</type><title>Systemic glutathione deficiency in symptom-free hiv-seropositive individuals</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>BUHL, R ; ARI JAFFE, H ; HOLROYD, K. J ; WELLS, F. B ; MASTRANGELI, A ; SALTINI, C ; CANTIN, A. M ; CRYSTAL, R. G</creator><creatorcontrib>BUHL, R ; ARI JAFFE, H ; HOLROYD, K. J ; WELLS, F. B ; MASTRANGELI, A ; SALTINI, C ; CANTIN, A. M ; CRYSTAL, R. G</creatorcontrib><description>To find out whether systemic glutathione deficiency is associated with human immunodeficiency virus (HIV) infection, thus contributing to the immunodeficiency state, glutathione concentrations in venous plasma and lung epithelial lining fluid (ELF) of symptom-free HIV-seropositive and normal individuals were measured. Total and reduced glutathione concentrations in the plasma of the HIV-infected subjects were about 30% of those in the normal individuals. Concentrations of these substances in the ELF of HIV-infected subjects were about 60% of those in the controls. There was no correlation between ELF and plasma concentrations of total or reduced glutathione. Since glutathione enhances immune function, glutathione deficiency may contribute to the progressive immune dysfunction of HIV infection.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>PMID: 2574255</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Lancet</publisher><subject>Adult ; AIDS/HIV ; Biological and medical sciences ; Bronchoalveolar Lavage Fluid - analysis ; Extracellular Space - analysis ; Extracellular Space - cytology ; Female ; Glutathione - analysis ; Glutathione - blood ; Glutathione - deficiency ; HIV Seropositivity - blood ; HIV Seropositivity - metabolism ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Leukocyte Count ; Lung - pathology ; Male ; Medical sciences ; Oxidation-Reduction ; Spectrophotometry ; T-Lymphocytes - pathology</subject><ispartof>The Lancet (British edition), 1989-12, Vol.2 (8675), p.1294-1298</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19542693$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2574255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BUHL, R</creatorcontrib><creatorcontrib>ARI JAFFE, H</creatorcontrib><creatorcontrib>HOLROYD, K. J</creatorcontrib><creatorcontrib>WELLS, F. B</creatorcontrib><creatorcontrib>MASTRANGELI, A</creatorcontrib><creatorcontrib>SALTINI, C</creatorcontrib><creatorcontrib>CANTIN, A. M</creatorcontrib><creatorcontrib>CRYSTAL, R. G</creatorcontrib><title>Systemic glutathione deficiency in symptom-free hiv-seropositive individuals</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>To find out whether systemic glutathione deficiency is associated with human immunodeficiency virus (HIV) infection, thus contributing to the immunodeficiency state, glutathione concentrations in venous plasma and lung epithelial lining fluid (ELF) of symptom-free HIV-seropositive and normal individuals were measured. Total and reduced glutathione concentrations in the plasma of the HIV-infected subjects were about 30% of those in the normal individuals. Concentrations of these substances in the ELF of HIV-infected subjects were about 60% of those in the controls. There was no correlation between ELF and plasma concentrations of total or reduced glutathione. Since glutathione enhances immune function, glutathione deficiency may contribute to the progressive immune dysfunction of HIV infection.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage Fluid - analysis</subject><subject>Extracellular Space - analysis</subject><subject>Extracellular Space - cytology</subject><subject>Female</subject><subject>Glutathione - analysis</subject><subject>Glutathione - blood</subject><subject>Glutathione - deficiency</subject><subject>HIV Seropositivity - blood</subject><subject>HIV Seropositivity - metabolism</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Leukocyte Count</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxidation-Reduction</subject><subject>Spectrophotometry</subject><subject>T-Lymphocytes - pathology</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j0tLxDAYRYMo4zj6E4RudBfIO81SBnWEggsV3JU0-epE-rJJB_rvLVhcXS7ncOGeoS0VWmAp9Oc52hIqCFaaq0t0FeM3IUQoIjdow6QWTMotKt7mmKANLvtqpmTTMfQdZB7q4AJ0bs5Cl8W5HVLf4noEyI7hhCOM_dDHkMIJFsGHU_CTbeI1uqiXgJs1d-jj6fF9f8DF6_PL_qHAA1V5wkBprpjzZGnM0Mp6ajUTWlaW0NxSUDIninrmpPCVcd4qKsFYwZXymhu-Q_d_u8PY_0wQU9mG6KBpbAf9FEttuMqV1It4u4pT1YIvhzG0dpzL9f7C71Zuo7NNPdrOhfivUSMFU4bzX49qZQs</recordid><startdate>19891202</startdate><enddate>19891202</enddate><creator>BUHL, R</creator><creator>ARI JAFFE, H</creator><creator>HOLROYD, K. J</creator><creator>WELLS, F. B</creator><creator>MASTRANGELI, A</creator><creator>SALTINI, C</creator><creator>CANTIN, A. M</creator><creator>CRYSTAL, R. G</creator><general>Lancet</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19891202</creationdate><title>Systemic glutathione deficiency in symptom-free hiv-seropositive individuals</title><author>BUHL, R ; ARI JAFFE, H ; HOLROYD, K. J ; WELLS, F. B ; MASTRANGELI, A ; SALTINI, C ; CANTIN, A. M ; CRYSTAL, R. G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p168t-e11862cd0168291bad1a72475ba018a1e658061d2c54db9cda615e9a4366d7393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Bronchoalveolar Lavage Fluid - analysis</topic><topic>Extracellular Space - analysis</topic><topic>Extracellular Space - cytology</topic><topic>Female</topic><topic>Glutathione - analysis</topic><topic>Glutathione - blood</topic><topic>Glutathione - deficiency</topic><topic>HIV Seropositivity - blood</topic><topic>HIV Seropositivity - metabolism</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Leukocyte Count</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxidation-Reduction</topic><topic>Spectrophotometry</topic><topic>T-Lymphocytes - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BUHL, R</creatorcontrib><creatorcontrib>ARI JAFFE, H</creatorcontrib><creatorcontrib>HOLROYD, K. J</creatorcontrib><creatorcontrib>WELLS, F. B</creatorcontrib><creatorcontrib>MASTRANGELI, A</creatorcontrib><creatorcontrib>SALTINI, C</creatorcontrib><creatorcontrib>CANTIN, A. M</creatorcontrib><creatorcontrib>CRYSTAL, R. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BUHL, R</au><au>ARI JAFFE, H</au><au>HOLROYD, K. J</au><au>WELLS, F. B</au><au>MASTRANGELI, A</au><au>SALTINI, C</au><au>CANTIN, A. M</au><au>CRYSTAL, R. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic glutathione deficiency in symptom-free hiv-seropositive individuals</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1989-12-02</date><risdate>1989</risdate><volume>2</volume><issue>8675</issue><spage>1294</spage><epage>1298</epage><pages>1294-1298</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>To find out whether systemic glutathione deficiency is associated with human immunodeficiency virus (HIV) infection, thus contributing to the immunodeficiency state, glutathione concentrations in venous plasma and lung epithelial lining fluid (ELF) of symptom-free HIV-seropositive and normal individuals were measured. Total and reduced glutathione concentrations in the plasma of the HIV-infected subjects were about 30% of those in the normal individuals. Concentrations of these substances in the ELF of HIV-infected subjects were about 60% of those in the controls. There was no correlation between ELF and plasma concentrations of total or reduced glutathione. Since glutathione enhances immune function, glutathione deficiency may contribute to the progressive immune dysfunction of HIV infection.</abstract><cop>London</cop><pub>Lancet</pub><pmid>2574255</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1989-12, Vol.2 (8675), p.1294-1298 |
| issn | 0140-6736 1474-547X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79368657 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult AIDS/HIV Biological and medical sciences Bronchoalveolar Lavage Fluid - analysis Extracellular Space - analysis Extracellular Space - cytology Female Glutathione - analysis Glutathione - blood Glutathione - deficiency HIV Seropositivity - blood HIV Seropositivity - metabolism Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Leukocyte Count Lung - pathology Male Medical sciences Oxidation-Reduction Spectrophotometry T-Lymphocytes - pathology |
| title | Systemic glutathione deficiency in symptom-free hiv-seropositive individuals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T07%3A45%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Systemic%20glutathione%20deficiency%20in%20symptom-free%20hiv-seropositive%20individuals&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=BUHL,%20R&rft.date=1989-12-02&rft.volume=2&rft.issue=8675&rft.spage=1294&rft.epage=1298&rft.pages=1294-1298&rft.issn=0140-6736&rft.eissn=1474-547X&rft.coden=LANCAO&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E79368657%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79368657&rft_id=info:pmid/2574255&rfr_iscdi=true |