Transduction potential of human retroviruses in highly proliferating small-cell lung cancer cells as well as non-proliferating hematopoietic stem cells

Direct gene transfer to solid tissues or metastatic cancer cells requires vectors capable of in vivo transduction to specific cells. The predominant retroviral vectors of murine origin are inactivated by human complement, which precludes their use in vivo. Such inactivation does not take place with...

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Veröffentlicht in:	APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 1997-09, Vol.105 (7-12), p.723-729
Hauptverfasser:	HANSEN, JOHN-ERIK S., GRAM, GREGERS J., NIELSEN, SUSANNE D., SØRENSEN, ANDERS, JENSEN, PETER B., SEHESTED, MAXWELL, NIELSEN, JENS O., RØRTH, MIKAEL
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antigens, CD34 - analysis Biological and medical sciences Carcinoma, Small Cell - virology Cell Division DNA, Viral - analysis gene therapy Gene Transfer Techniques Genetic Vectors hematopoietic stem cells Hematopoietic Stem Cells - virology HIV-1 - growth & development Human immunodeficiency virus 1 Human T-lymphotropic virus 1 Humans Medical sciences Other treatments Proviruses - genetics Retroviridae Retroviridae - genetics Retrovirus small-cell lung cancer Transduction, Genetic Treatment. General aspects Tumor Cells, Cultured Tumors vector
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