Bacterial pneumonia causes augmented expression of the secretory leukoprotease inhibitor gene in the murine lung

The cDNA of murine secretory leukoprotease inhibitor (SLPI) was cloned from a mouse lung cDNA library. The amino acid sequence deduced from the cDNA showed 58 and 51% homology with those of human and porcine SLPI, respectively. A two-domain structure with similar amino acid sequences, four intradoma...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 1997-10, Vol.156 (4), p.1235-1240
Hauptverfasser:	ABE, T, TOMINAGA, Y, KIKUCHI, T, WATANABE, A, SATOH, K, WATANABE, Y, NUKIWA, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal bacterial diseases Animals Bacterial diseases Base Sequence Biological and medical sciences Blotting, Northern Blotting, Southern Cells, Cultured Disease Models, Animal DNA Probes - chemistry Gene Expression Regulation, Enzymologic Humans Infectious diseases Lung - enzymology Lung - pathology Male Medical sciences Mice Mice, Inbred C57BL Molecular Sequence Data Pneumonia, Pneumococcal - enzymology Pneumonia, Pneumococcal - pathology Polymerase Chain Reaction Protein Biosynthesis Proteinase Inhibitory Proteins, Secretory Proteins - genetics RNA, Messenger - analysis Secretory Leukocyte Peptidase Inhibitor Serine Proteinase Inhibitors - biosynthesis Serine Proteinase Inhibitors - genetics Spleen - enzymology Spleen - pathology Streptococcus pneumoniae Swine
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