Vancomycin-resistant Enterococcus raffinosus: Molecular epidemiology, species identification error, and frequency of occurrence in a national resistance surveillance program
Enterococcal blood stream infections are the third most common among all nosocomial blood stream infections in the United States and the occurrence of glycopeptide (vancomycin, teicoplanin) resistance in these isolates has markedly increased. Control of hospital-acquired infections with vancomycin-r...
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Veröffentlicht in: | Diagnostic microbiology and infectious disease 1997-09, Vol.29 (1), p.43-49 |
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description | Enterococcal blood stream infections are the third most common among all nosocomial blood stream infections in the United States and the occurrence of glycopeptide (vancomycin, teicoplanin) resistance in these isolates has markedly increased. Control of hospital-acquired infections with vancomycin-resistant enterococci requires high quality antimicrobial susceptibility test methods and species identification procedures as a supplement to epidemiologic investigation and appropriate infection control procedures. In this report, bacteremias caused by
Enterococcus avium (BioMerieux Vitek, Hazelwood, MO, USA) were observed to be
Enterococcus raffinosus infections (six of eight cases; 1.1% of all cases) when reference biochemical identification methods were applied. The vancomycin-susceptible
E. raffinosis (two strains) and
E. avium (two strains) had unique phenotypic and genotypic molecular profiles. In contrast, four vancomycin-resistant
E. raffinosus strains (
van A by polymerase chain reaction) from a single institution had the same phenotypic and molecular (PCR, PFGE, ribotyping) pattern, indicating clonal dissemination among four patients over a 66-day period. Clinical laboratories should be aware of the high probability that
van A genes may be transferred from
Enterococcus faecium or
Enterococcus faecalis to other more rarely encountered
Enterococcus species. Also contemporary, widely used commercial identification systems may fail to accurately identify those rare species. Errors appear to be most prevalent for
E. avium, Enterococcus durans, and
E. raffinosus based on the experience of the SCOPE Program. |
doi_str_mv | 10.1016/S0732-8893(97)00059-X |
format | Article |
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Enterococcus avium (BioMerieux Vitek, Hazelwood, MO, USA) were observed to be
Enterococcus raffinosus infections (six of eight cases; 1.1% of all cases) when reference biochemical identification methods were applied. The vancomycin-susceptible
E. raffinosis (two strains) and
E. avium (two strains) had unique phenotypic and genotypic molecular profiles. In contrast, four vancomycin-resistant
E. raffinosus strains (
van A by polymerase chain reaction) from a single institution had the same phenotypic and molecular (PCR, PFGE, ribotyping) pattern, indicating clonal dissemination among four patients over a 66-day period. Clinical laboratories should be aware of the high probability that
van A genes may be transferred from
Enterococcus faecium or
Enterococcus faecalis to other more rarely encountered
Enterococcus species. Also contemporary, widely used commercial identification systems may fail to accurately identify those rare species. Errors appear to be most prevalent for
E. avium, Enterococcus durans, and
E. raffinosus based on the experience of the SCOPE Program.</description><identifier>ISSN: 0732-8893</identifier><identifier>EISSN: 1879-0070</identifier><identifier>DOI: 10.1016/S0732-8893(97)00059-X</identifier><identifier>PMID: 9350415</identifier><identifier>CODEN: DMIDDZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial Typing Techniques ; Bacteriology ; Biological and medical sciences ; Cross Infection - blood ; Cross Infection - microbiology ; Drug Resistance, Microbial - genetics ; Enterococcus - classification ; Enterococcus - drug effects ; Enterococcus - genetics ; Enterococcus - isolation & purification ; Fundamental and applied biological sciences. Psychology ; Humans ; Medical sciences ; Microbial Sensitivity Tests ; Microbiology ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Vancomycin - pharmacology</subject><ispartof>Diagnostic microbiology and infectious disease, 1997-09, Vol.29 (1), p.43-49</ispartof><rights>1997</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-7234038ad3769ce64df437a06743854520f9fbc824aeec2c1a7d7cda5e012b423</citedby><cites>FETCH-LOGICAL-c389t-7234038ad3769ce64df437a06743854520f9fbc824aeec2c1a7d7cda5e012b423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0732-8893(97)00059-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2093857$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9350415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilke, Werner W.</creatorcontrib><creatorcontrib>Marshall, Steven A.</creatorcontrib><creatorcontrib>Coffman, Stacy L.</creatorcontrib><creatorcontrib>Pfaller, Michael A.</creatorcontrib><creatorcontrib>Edmund, Michael B.</creatorcontrib><creatorcontrib>Wenzel, Richard P.</creatorcontrib><creatorcontrib>Jones, Ronald N.</creatorcontrib><title>Vancomycin-resistant Enterococcus raffinosus: Molecular epidemiology, species identification error, and frequency of occurrence in a national resistance surveillance program</title><title>Diagnostic microbiology and infectious disease</title><addtitle>Diagn Microbiol Infect Dis</addtitle><description>Enterococcal blood stream infections are the third most common among all nosocomial blood stream infections in the United States and the occurrence of glycopeptide (vancomycin, teicoplanin) resistance in these isolates has markedly increased. Control of hospital-acquired infections with vancomycin-resistant enterococci requires high quality antimicrobial susceptibility test methods and species identification procedures as a supplement to epidemiologic investigation and appropriate infection control procedures. In this report, bacteremias caused by
Enterococcus avium (BioMerieux Vitek, Hazelwood, MO, USA) were observed to be
Enterococcus raffinosus infections (six of eight cases; 1.1% of all cases) when reference biochemical identification methods were applied. The vancomycin-susceptible
E. raffinosis (two strains) and
E. avium (two strains) had unique phenotypic and genotypic molecular profiles. In contrast, four vancomycin-resistant
E. raffinosus strains (
van A by polymerase chain reaction) from a single institution had the same phenotypic and molecular (PCR, PFGE, ribotyping) pattern, indicating clonal dissemination among four patients over a 66-day period. Clinical laboratories should be aware of the high probability that
van A genes may be transferred from
Enterococcus faecium or
Enterococcus faecalis to other more rarely encountered
Enterococcus species. Also contemporary, widely used commercial identification systems may fail to accurately identify those rare species. Errors appear to be most prevalent for
E. avium, Enterococcus durans, and
E. raffinosus based on the experience of the SCOPE Program.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial Typing Techniques</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Cross Infection - blood</subject><subject>Cross Infection - microbiology</subject><subject>Drug Resistance, Microbial - genetics</subject><subject>Enterococcus - classification</subject><subject>Enterococcus - drug effects</subject><subject>Enterococcus - genetics</subject><subject>Enterococcus - isolation & purification</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Vancomycin - pharmacology</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuKFTEQhoMo43H0EQayEFGY1nQn3em4ERnGC4y48MLsQk66MkS6k2NV98B5KN_RnItn6ypU6qvUn_9n7KIWr2tRd2--CS2bqu-NfGn0KyFEa6rbB2xV99pUQmjxkK1OyGP2hOiXEHVjlDhjZ0a2QtXtiv356ZLP09bHVCFQpNmlmV-nGTD77P1CHF0IMWVa6C3_kkfwy-iQwyYOMMU85rvtJacN-AjEy12aY4jezTEnDogZL7lLAw8IvxdIfstz4LuHEUsFPCbueNrjbuT_JJQGLXgPcRz3xQbzHbrpKXsU3Ejw7Hiesx8frr9ffapuvn78fPX-pvKyN3OlG6mE7N0gdWc8dGoISmonOq1k36q2EcGEte8b5QB842unB-0H10IxaK0aec5eHN4te4tqmu0UycNODOSFrDay61XXFbA9gB4zEUKwG4yTw62thd3FZPcx2V0G1mi7j8nelrmL44JlPcFwmjrmUvrPj31H3o0BiwuRTlgjTPmILti7AwbFjPsIaKnEUAwbIoKf7ZDjf4T8Beh_tKw</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Wilke, Werner W.</creator><creator>Marshall, Steven A.</creator><creator>Coffman, Stacy L.</creator><creator>Pfaller, Michael A.</creator><creator>Edmund, Michael B.</creator><creator>Wenzel, Richard P.</creator><creator>Jones, Ronald N.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970901</creationdate><title>Vancomycin-resistant Enterococcus raffinosus: Molecular epidemiology, species identification error, and frequency of occurrence in a national resistance surveillance program</title><author>Wilke, Werner W. ; Marshall, Steven A. ; Coffman, Stacy L. ; Pfaller, Michael A. ; Edmund, Michael B. ; Wenzel, Richard P. ; Jones, Ronald N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-7234038ad3769ce64df437a06743854520f9fbc824aeec2c1a7d7cda5e012b423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial Typing Techniques</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Cross Infection - blood</topic><topic>Cross Infection - microbiology</topic><topic>Drug Resistance, Microbial - genetics</topic><topic>Enterococcus - classification</topic><topic>Enterococcus - drug effects</topic><topic>Enterococcus - genetics</topic><topic>Enterococcus - isolation & purification</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Vancomycin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilke, Werner W.</creatorcontrib><creatorcontrib>Marshall, Steven A.</creatorcontrib><creatorcontrib>Coffman, Stacy L.</creatorcontrib><creatorcontrib>Pfaller, Michael A.</creatorcontrib><creatorcontrib>Edmund, Michael B.</creatorcontrib><creatorcontrib>Wenzel, Richard P.</creatorcontrib><creatorcontrib>Jones, Ronald N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic microbiology and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilke, Werner W.</au><au>Marshall, Steven A.</au><au>Coffman, Stacy L.</au><au>Pfaller, Michael A.</au><au>Edmund, Michael B.</au><au>Wenzel, Richard P.</au><au>Jones, Ronald N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vancomycin-resistant Enterococcus raffinosus: Molecular epidemiology, species identification error, and frequency of occurrence in a national resistance surveillance program</atitle><jtitle>Diagnostic microbiology and infectious disease</jtitle><addtitle>Diagn Microbiol Infect Dis</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>29</volume><issue>1</issue><spage>43</spage><epage>49</epage><pages>43-49</pages><issn>0732-8893</issn><eissn>1879-0070</eissn><coden>DMIDDZ</coden><abstract>Enterococcal blood stream infections are the third most common among all nosocomial blood stream infections in the United States and the occurrence of glycopeptide (vancomycin, teicoplanin) resistance in these isolates has markedly increased. Control of hospital-acquired infections with vancomycin-resistant enterococci requires high quality antimicrobial susceptibility test methods and species identification procedures as a supplement to epidemiologic investigation and appropriate infection control procedures. In this report, bacteremias caused by
Enterococcus avium (BioMerieux Vitek, Hazelwood, MO, USA) were observed to be
Enterococcus raffinosus infections (six of eight cases; 1.1% of all cases) when reference biochemical identification methods were applied. The vancomycin-susceptible
E. raffinosis (two strains) and
E. avium (two strains) had unique phenotypic and genotypic molecular profiles. In contrast, four vancomycin-resistant
E. raffinosus strains (
van A by polymerase chain reaction) from a single institution had the same phenotypic and molecular (PCR, PFGE, ribotyping) pattern, indicating clonal dissemination among four patients over a 66-day period. Clinical laboratories should be aware of the high probability that
van A genes may be transferred from
Enterococcus faecium or
Enterococcus faecalis to other more rarely encountered
Enterococcus species. Also contemporary, widely used commercial identification systems may fail to accurately identify those rare species. Errors appear to be most prevalent for
E. avium, Enterococcus durans, and
E. raffinosus based on the experience of the SCOPE Program.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9350415</pmid><doi>10.1016/S0732-8893(97)00059-X</doi><tpages>7</tpages></addata></record> |
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source | MEDLINE; Access via ScienceDirect (Elsevier) |
subjects | Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Typing Techniques Bacteriology Biological and medical sciences Cross Infection - blood Cross Infection - microbiology Drug Resistance, Microbial - genetics Enterococcus - classification Enterococcus - drug effects Enterococcus - genetics Enterococcus - isolation & purification Fundamental and applied biological sciences. Psychology Humans Medical sciences Microbial Sensitivity Tests Microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Pharmacology. Drug treatments Polymerase Chain Reaction Vancomycin - pharmacology |
title | Vancomycin-resistant Enterococcus raffinosus: Molecular epidemiology, species identification error, and frequency of occurrence in a national resistance surveillance program |
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