Protease Activation Is Required for Glucocorticoid-Induced Apoptosis in Chronic Lymphocytic Leukemic Lymphocytes

Recent work has demonstrated that glucocorticoids, nucleoside analogues, and other cancer chemotherapeutics induce apoptosis in chronic lymphocytic leukemia (CLL) cells. In this study, we investigated the involvement of protease activation in these responses using selective peptide inhibitors of the...

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Veröffentlicht in:	Blood 1997-11, Vol.90 (9), p.3673-3681
Hauptverfasser:	Chandra, Joya, Gilbreath, Joyce, Freireich, Emil J, Kliche, Kay-Oliver, Andreeff, Michael, Keating, Michael, McConkey, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Caspase 1 Chemotherapy Cysteine Endopeptidases - metabolism Endopeptidases - metabolism Enzyme Activation Glucocorticoids - pharmacology Humans Leukemia, Lymphocytic, Chronic, B-Cell - enzymology Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphocytes - enzymology Lymphocytes - pathology Medical sciences Pharmacology. Drug treatments Tumor Cells, Cultured
Online-Zugang:	Volltext
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