Increasing the chance to accept HLA-ABDR mismatched donor in kidney transplantation
Two hundred and fifty-three kidney transplantations (KT) which included 68 (26.9%) living-related (L) and 185 (73.1%) cadaveric (C) KT with 0-6 HLA-ABDR mismatches (MM) were studied for the association of HLA-ABDR-MM specificities and the occurrence of graft rejection (GR). It was found that the inc...
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| Veröffentlicht in: | Journal of the Medical Association of Thailand 1997-09, Vol.80 Suppl 1, p.S43-S51 |
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| container_title | Journal of the Medical Association of Thailand |
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| creator | Sujirachato, K Chiewsilp, P Mongkolsuk, T Junpong, S Sumethkul, V Jirasiritham, S Sriphojanart, S Kanjanapanjapol, S Domrongkitchaiporn, S |
| description | Two hundred and fifty-three kidney transplantations (KT) which included 68 (26.9%) living-related (L) and 185 (73.1%) cadaveric (C) KT with 0-6 HLA-ABDR mismatches (MM) were studied for the association of HLA-ABDR-MM specificities and the occurrence of graft rejection (GR). It was found that the incidence of acute and chronic rejection in CKT was significantly higher than that of LKT (42.1% vs 22.1%, p < 0.005). It was also observed that the number of ABDR-MM, AB-MM and BDR-MM which is important in GR were 2 times in CKT compared with LKT. The analysis revealed that HLA-A11, B16, B22, B35, B5, B17 and DR3 were good responders, whereas, HLA-A30, A2, B62, B18, B40, B44, B46 and DR10 were good stimulators for KT. GR were significantly increased with p < 0.01 and < 0.05, respectively. Specific HLA-MM specificities played a significant role in GR, i.e., some HLA-MM specificities were permissible, whereas, some were immunogenic. Careful selection of donor and recipient for KT by avoiding immunogenic HLA-MM and/or accepting permissible HLA-MM will improve graft survival and reduce the demand of kidney for retransplantation. |
| format | Article |
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It was found that the incidence of acute and chronic rejection in CKT was significantly higher than that of LKT (42.1% vs 22.1%, p < 0.005). It was also observed that the number of ABDR-MM, AB-MM and BDR-MM which is important in GR were 2 times in CKT compared with LKT. The analysis revealed that HLA-A11, B16, B22, B35, B5, B17 and DR3 were good responders, whereas, HLA-A30, A2, B62, B18, B40, B44, B46 and DR10 were good stimulators for KT. GR were significantly increased with p < 0.01 and < 0.05, respectively. Specific HLA-MM specificities played a significant role in GR, i.e., some HLA-MM specificities were permissible, whereas, some were immunogenic. Careful selection of donor and recipient for KT by avoiding immunogenic HLA-MM and/or accepting permissible HLA-MM will improve graft survival and reduce the demand of kidney for retransplantation.</description><identifier>ISSN: 0125-2208</identifier><identifier>PMID: 9347645</identifier><language>eng</language><publisher>Thailand</publisher><subject>Alleles ; Cadaver ; Chi-Square Distribution ; Graft Rejection - epidemiology ; Graft Rejection - immunology ; Graft Survival - immunology ; Haplotypes ; Histocompatibility Testing ; HLA Antigens - analysis ; Humans ; Incidence ; Kidney Transplantation - immunology ; Retrospective Studies ; Thailand - epidemiology</subject><ispartof>Journal of the Medical Association of Thailand, 1997-09, Vol.80 Suppl 1, p.S43-S51</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9347645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sujirachato, K</creatorcontrib><creatorcontrib>Chiewsilp, P</creatorcontrib><creatorcontrib>Mongkolsuk, T</creatorcontrib><creatorcontrib>Junpong, S</creatorcontrib><creatorcontrib>Sumethkul, V</creatorcontrib><creatorcontrib>Jirasiritham, S</creatorcontrib><creatorcontrib>Sriphojanart, S</creatorcontrib><creatorcontrib>Kanjanapanjapol, S</creatorcontrib><creatorcontrib>Domrongkitchaiporn, S</creatorcontrib><title>Increasing the chance to accept HLA-ABDR mismatched donor in kidney transplantation</title><title>Journal of the Medical Association of Thailand</title><addtitle>J Med Assoc Thai</addtitle><description>Two hundred and fifty-three kidney transplantations (KT) which included 68 (26.9%) living-related (L) and 185 (73.1%) cadaveric (C) KT with 0-6 HLA-ABDR mismatches (MM) were studied for the association of HLA-ABDR-MM specificities and the occurrence of graft rejection (GR). It was found that the incidence of acute and chronic rejection in CKT was significantly higher than that of LKT (42.1% vs 22.1%, p < 0.005). It was also observed that the number of ABDR-MM, AB-MM and BDR-MM which is important in GR were 2 times in CKT compared with LKT. The analysis revealed that HLA-A11, B16, B22, B35, B5, B17 and DR3 were good responders, whereas, HLA-A30, A2, B62, B18, B40, B44, B46 and DR10 were good stimulators for KT. GR were significantly increased with p < 0.01 and < 0.05, respectively. Specific HLA-MM specificities played a significant role in GR, i.e., some HLA-MM specificities were permissible, whereas, some were immunogenic. Careful selection of donor and recipient for KT by avoiding immunogenic HLA-MM and/or accepting permissible HLA-MM will improve graft survival and reduce the demand of kidney for retransplantation.</description><subject>Alleles</subject><subject>Cadaver</subject><subject>Chi-Square Distribution</subject><subject>Graft Rejection - epidemiology</subject><subject>Graft Rejection - immunology</subject><subject>Graft Survival - immunology</subject><subject>Haplotypes</subject><subject>Histocompatibility Testing</subject><subject>HLA Antigens - analysis</subject><subject>Humans</subject><subject>Incidence</subject><subject>Kidney Transplantation - immunology</subject><subject>Retrospective Studies</subject><subject>Thailand - epidemiology</subject><issn>0125-2208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkDtPwzAURj2ASin8BCRPbJH8Sm4yhvJopUpIPOboxr6hgcQJtjv031OJTt9y9OnoXLClkCrPlBLlFbuO8VsIk1eFXrBFpQ0UJl-y9623gTD2_ounPXG7R2-Jp4mjtTQnvtnVWf3w-MbHPo6Y7J4cd5OfAu89_-mdpyNPAX2cB_QJUz_5G3bZ4RDp9rwr9vn89LHeZLvXl-263mWzVDJlqgDVOahAIAhwDgVoUASAuZJtm7dSS63b1oAzpTOkCEvZVUaUJenOWr1i9_-_c5h-DxRTc3K0NJxEaDrEBipd5KDUCbw7g4d2JNfMoR8xHJtzBf0HlthXUQ</recordid><startdate>199709</startdate><enddate>199709</enddate><creator>Sujirachato, K</creator><creator>Chiewsilp, P</creator><creator>Mongkolsuk, T</creator><creator>Junpong, S</creator><creator>Sumethkul, V</creator><creator>Jirasiritham, S</creator><creator>Sriphojanart, S</creator><creator>Kanjanapanjapol, S</creator><creator>Domrongkitchaiporn, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199709</creationdate><title>Increasing the chance to accept HLA-ABDR mismatched donor in kidney transplantation</title><author>Sujirachato, K ; Chiewsilp, P ; Mongkolsuk, T ; Junpong, S ; Sumethkul, V ; Jirasiritham, S ; Sriphojanart, S ; Kanjanapanjapol, S ; Domrongkitchaiporn, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p121t-2672fd7970a707dda07372e77a521bb5b13133bb47d48d4e2ea81f94088e3fcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Alleles</topic><topic>Cadaver</topic><topic>Chi-Square Distribution</topic><topic>Graft Rejection - epidemiology</topic><topic>Graft Rejection - immunology</topic><topic>Graft Survival - immunology</topic><topic>Haplotypes</topic><topic>Histocompatibility Testing</topic><topic>HLA Antigens - analysis</topic><topic>Humans</topic><topic>Incidence</topic><topic>Kidney Transplantation - immunology</topic><topic>Retrospective Studies</topic><topic>Thailand - epidemiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Sujirachato, K</creatorcontrib><creatorcontrib>Chiewsilp, P</creatorcontrib><creatorcontrib>Mongkolsuk, T</creatorcontrib><creatorcontrib>Junpong, S</creatorcontrib><creatorcontrib>Sumethkul, V</creatorcontrib><creatorcontrib>Jirasiritham, S</creatorcontrib><creatorcontrib>Sriphojanart, S</creatorcontrib><creatorcontrib>Kanjanapanjapol, S</creatorcontrib><creatorcontrib>Domrongkitchaiporn, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Medical Association of Thailand</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sujirachato, K</au><au>Chiewsilp, P</au><au>Mongkolsuk, T</au><au>Junpong, S</au><au>Sumethkul, V</au><au>Jirasiritham, S</au><au>Sriphojanart, S</au><au>Kanjanapanjapol, S</au><au>Domrongkitchaiporn, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increasing the chance to accept HLA-ABDR mismatched donor in kidney transplantation</atitle><jtitle>Journal of the Medical Association of Thailand</jtitle><addtitle>J Med Assoc Thai</addtitle><date>1997-09</date><risdate>1997</risdate><volume>80 Suppl 1</volume><spage>S43</spage><epage>S51</epage><pages>S43-S51</pages><issn>0125-2208</issn><abstract>Two hundred and fifty-three kidney transplantations (KT) which included 68 (26.9%) living-related (L) and 185 (73.1%) cadaveric (C) KT with 0-6 HLA-ABDR mismatches (MM) were studied for the association of HLA-ABDR-MM specificities and the occurrence of graft rejection (GR). It was found that the incidence of acute and chronic rejection in CKT was significantly higher than that of LKT (42.1% vs 22.1%, p < 0.005). It was also observed that the number of ABDR-MM, AB-MM and BDR-MM which is important in GR were 2 times in CKT compared with LKT. The analysis revealed that HLA-A11, B16, B22, B35, B5, B17 and DR3 were good responders, whereas, HLA-A30, A2, B62, B18, B40, B44, B46 and DR10 were good stimulators for KT. GR were significantly increased with p < 0.01 and < 0.05, respectively. Specific HLA-MM specificities played a significant role in GR, i.e., some HLA-MM specificities were permissible, whereas, some were immunogenic. Careful selection of donor and recipient for KT by avoiding immunogenic HLA-MM and/or accepting permissible HLA-MM will improve graft survival and reduce the demand of kidney for retransplantation.</abstract><cop>Thailand</cop><pmid>9347645</pmid></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Alleles Cadaver Chi-Square Distribution Graft Rejection - epidemiology Graft Rejection - immunology Graft Survival - immunology Haplotypes Histocompatibility Testing HLA Antigens - analysis Humans Incidence Kidney Transplantation - immunology Retrospective Studies Thailand - epidemiology |
| title | Increasing the chance to accept HLA-ABDR mismatched donor in kidney transplantation |
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