Substrate-bound carbohydrates stimulate signal transduction and neurite outgrowth in an olfactory neuron cell line
SUBPOPULATIONS of olfactory receptor neurons, which are dispersed throughout the olfactory neuroepithelium, express specific cell surface carbohydrates and project to discrete regions of the olfactory bulb. Cell surface carbohydrates such as N-acetyl-lactosamine have been postulated to mediate sorti...
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| Veröffentlicht in: | Neuroreport 1997-10, Vol.8 (15), p.3183-3188 |
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| creator | Puche, A C Bartlett, P F Key, B |
| description | SUBPOPULATIONS of olfactory receptor neurons, which are dispersed throughout the olfactory neuroepithelium, express specific cell surface carbohydrates and project to discrete regions of the olfactory bulb. Cell surface carbohydrates such as N-acetyl-lactosamine have been postulated to mediate sorting and selective fasciculation of discrete axon subpopulations during development of the olfactory pathway. Substrate-bound N-acetyl-lactosamine promotes neurite outgrowth by both clonal olfactory receptor neuron cell lines and olfactory receptor neurons in vitro, indicating that cell surface carbohydrates may be ligands for receptor-mediated stimulation of axon growth in vivo. In the present study, the role of transmembrane signaling in N-acetyl-lactosamine-stimulated neurite outgrowth was examined in the clonal olfactory neuron cell line 4.4.2. Substrate-bound N-acetyl-lactosamine stimulated neurite outgrowth which was specifically inhibited by antagonists to N- and L-type calcium channels and to tyrosine kinase phosphorylation. These results indicate that N-acetyl-lactosamine can evoke transmembrane receptor-mediated responses capable of influencing neurite outgrowth. |
| doi_str_mv | 10.1097/00001756-199710200-00001 |
| format | Article |
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Cell surface carbohydrates such as N-acetyl-lactosamine have been postulated to mediate sorting and selective fasciculation of discrete axon subpopulations during development of the olfactory pathway. Substrate-bound N-acetyl-lactosamine promotes neurite outgrowth by both clonal olfactory receptor neuron cell lines and olfactory receptor neurons in vitro, indicating that cell surface carbohydrates may be ligands for receptor-mediated stimulation of axon growth in vivo. In the present study, the role of transmembrane signaling in N-acetyl-lactosamine-stimulated neurite outgrowth was examined in the clonal olfactory neuron cell line 4.4.2. Substrate-bound N-acetyl-lactosamine stimulated neurite outgrowth which was specifically inhibited by antagonists to N- and L-type calcium channels and to tyrosine kinase phosphorylation. 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Sensory receptors ; Stimulation, Chemical ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 1997-10, Vol.8 (15), p.3183-3188</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4151-5e886c8b74c9bd1a9381bf699784842a356db925f02a27f332197ad4533fa3203</citedby><cites>FETCH-LOGICAL-c4151-5e886c8b74c9bd1a9381bf699784842a356db925f02a27f332197ad4533fa3203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2845515$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9351640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puche, A C</creatorcontrib><creatorcontrib>Bartlett, P F</creatorcontrib><creatorcontrib>Key, B</creatorcontrib><title>Substrate-bound carbohydrates stimulate signal transduction and neurite outgrowth in an olfactory neuron cell line</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>SUBPOPULATIONS of olfactory receptor neurons, which are dispersed throughout the olfactory neuroepithelium, express specific cell surface carbohydrates and project to discrete regions of the olfactory bulb. Cell surface carbohydrates such as N-acetyl-lactosamine have been postulated to mediate sorting and selective fasciculation of discrete axon subpopulations during development of the olfactory pathway. Substrate-bound N-acetyl-lactosamine promotes neurite outgrowth by both clonal olfactory receptor neuron cell lines and olfactory receptor neurons in vitro, indicating that cell surface carbohydrates may be ligands for receptor-mediated stimulation of axon growth in vivo. In the present study, the role of transmembrane signaling in N-acetyl-lactosamine-stimulated neurite outgrowth was examined in the clonal olfactory neuron cell line 4.4.2. Substrate-bound N-acetyl-lactosamine stimulated neurite outgrowth which was specifically inhibited by antagonists to N- and L-type calcium channels and to tyrosine kinase phosphorylation. These results indicate that N-acetyl-lactosamine can evoke transmembrane receptor-mediated responses capable of influencing neurite outgrowth.</description><subject>Amino Sugars - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Agonists - pharmacology</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cell Line</subject><subject>Clone Cells</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mice</subject><subject>Neurites - drug effects</subject><subject>Olfactory Bulb - drug effects</subject><subject>Olfactory Bulb - physiology</subject><subject>Phospholipases A - metabolism</subject><subject>Phosphorylation</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Signal Transduction - drug effects</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. 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Psychology</topic><topic>Mice</topic><topic>Neurites - drug effects</topic><topic>Olfactory Bulb - drug effects</topic><topic>Olfactory Bulb - physiology</topic><topic>Phospholipases A - metabolism</topic><topic>Phosphorylation</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Stimulation, Chemical</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puche, A C</creatorcontrib><creatorcontrib>Bartlett, P F</creatorcontrib><creatorcontrib>Key, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Puche, A C</au><au>Bartlett, P F</au><au>Key, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substrate-bound carbohydrates stimulate signal transduction and neurite outgrowth in an olfactory neuron cell line</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1997-10-20</date><risdate>1997</risdate><volume>8</volume><issue>15</issue><spage>3183</spage><epage>3188</epage><pages>3183-3188</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>SUBPOPULATIONS of olfactory receptor neurons, which are dispersed throughout the olfactory neuroepithelium, express specific cell surface carbohydrates and project to discrete regions of the olfactory bulb. Cell surface carbohydrates such as N-acetyl-lactosamine have been postulated to mediate sorting and selective fasciculation of discrete axon subpopulations during development of the olfactory pathway. Substrate-bound N-acetyl-lactosamine promotes neurite outgrowth by both clonal olfactory receptor neuron cell lines and olfactory receptor neurons in vitro, indicating that cell surface carbohydrates may be ligands for receptor-mediated stimulation of axon growth in vivo. In the present study, the role of transmembrane signaling in N-acetyl-lactosamine-stimulated neurite outgrowth was examined in the clonal olfactory neuron cell line 4.4.2. Substrate-bound N-acetyl-lactosamine stimulated neurite outgrowth which was specifically inhibited by antagonists to N- and L-type calcium channels and to tyrosine kinase phosphorylation. These results indicate that N-acetyl-lactosamine can evoke transmembrane receptor-mediated responses capable of influencing neurite outgrowth.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9351640</pmid><doi>10.1097/00001756-199710200-00001</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Amino Sugars - pharmacology Animals Biological and medical sciences Calcium Channel Agonists - pharmacology Calcium Channel Blockers - pharmacology Cell Line Clone Cells Fundamental and applied biological sciences. Psychology Mice Neurites - drug effects Olfactory Bulb - drug effects Olfactory Bulb - physiology Phospholipases A - metabolism Phosphorylation Protein-Tyrosine Kinases - metabolism Signal Transduction - drug effects Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Stimulation, Chemical Vertebrates: nervous system and sense organs |
| title | Substrate-bound carbohydrates stimulate signal transduction and neurite outgrowth in an olfactory neuron cell line |
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