Identification of Two Nucleotide-Binding Domains on the PB1 Subunit of Influenza Virus RNA Polymerase

Influenza virus RNA polymerase is a multifunctional and multisubunit enzyme consisting of three viral P proteins, PB1, PB2, and PA. We have previously shown that radioactive 8-azido GTP (8-N3 GTP) was photo-crosslinked specifically to the PB1 subunit. Here we confirmed the specific crosslinking of P...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 1997-09, Vol.122 (3), p.627-634
Hauptverfasser:	Asano, Yukiyasu, Ishihama, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Azides - analysis Azides - metabolism Binding Sites cross-linking Cross-Linking Reagents - analysis Cross-Linking Reagents - metabolism DNA-Directed RNA Polymerases - analysis DNA-Directed RNA Polymerases - metabolism Escherichia coli - enzymology Escherichia coli - genetics Guanosine Triphosphate - analogs & derivatives Guanosine Triphosphate - analysis Guanosine Triphosphate - metabolism Influenza A virus - enzymology influenza virus Macromolecular Substances Peptide Hydrolases - metabolism Peptide Mapping RNA polymerase Serine Endopeptidases - metabolism Serine Endopeptidases - pharmacology substrate binding Viral Proteins - analysis Viral Proteins - metabolism
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