Multiple anthelmintic resistance in Haemonchus contortus on a sheep farm in Kenya
Multiple resistance to albendazole, thiophanate, levamisole and orally administered invermectin was detected in an isolate of Haemonchus contortus in sheep on a farm where benzimidazole resistance had already been identified. Following a faecal egg count reduction test, this was confirmed by both cr...
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| Veröffentlicht in: | Veterinary research communications 1997-10, Vol.21 (7), p.483-491 |
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| creator | Waruiru, R M Ngotho, J W Mukiri, J G |
| description | Multiple resistance to albendazole, thiophanate, levamisole and orally administered invermectin was detected in an isolate of Haemonchus contortus in sheep on a farm where benzimidazole resistance had already been identified. Following a faecal egg count reduction test, this was confirmed by both critical and controlled anthelmintic tests. Different groups of sheep infected naturally or given an experimental infection with the benzimidazole-resistant isolate were treated with the recommended doses of various anthelmintics. Compared to the control group, the percentage reductions in the faecal egg counts of sheep treated with albendazole, thiophanate, levamisole and ivermectin varied between 38.2% and 79.1% and the residual worm counts between 27.3% and 57.5%. The results indicate the presence of multiple anthelmintic resistance in this isolate of H. contortus. Sheep treated with closantel showed 100% reductions in faecal egg and worm counts, indicating that this drug was very effective against the population of H. contortus on the farm. |
| doi_str_mv | 10.1023/A:1005990303552 |
| format | Article |
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Following a faecal egg count reduction test, this was confirmed by both critical and controlled anthelmintic tests. Different groups of sheep infected naturally or given an experimental infection with the benzimidazole-resistant isolate were treated with the recommended doses of various anthelmintics. Compared to the control group, the percentage reductions in the faecal egg counts of sheep treated with albendazole, thiophanate, levamisole and ivermectin varied between 38.2% and 79.1% and the residual worm counts between 27.3% and 57.5%. The results indicate the presence of multiple anthelmintic resistance in this isolate of H. contortus. Sheep treated with closantel showed 100% reductions in faecal egg and worm counts, indicating that this drug was very effective against the population of H. contortus on the farm.</description><identifier>ISSN: 0165-7380</identifier><identifier>DOI: 10.1023/A:1005990303552</identifier><identifier>PMID: 9345715</identifier><language>eng</language><publisher>Netherlands</publisher><subject><![CDATA[Administration, Oral ; Albendazole - administration & dosage ; Albendazole - pharmacology ; Albendazole - therapeutic use ; Animals ; Anthelmintics - administration & dosage ; Anthelmintics - pharmacology ; Anthelmintics - therapeutic use ; Benzimidazoles - administration & dosage ; Benzimidazoles - pharmacology ; Benzimidazoles - therapeutic use ; Dose-Response Relationship, Drug ; Drug Resistance, Multiple ; Feces - parasitology ; Haemonchiasis - drug therapy ; Haemonchiasis - epidemiology ; Haemonchiasis - veterinary ; Haemonchus - drug effects ; Haemonchus - isolation & purification ; Ivermectin - administration & dosage ; Ivermectin - pharmacology ; Ivermectin - therapeutic use ; Kenya - epidemiology ; Levamisole - administration & dosage ; Levamisole - pharmacology ; Levamisole - therapeutic use ; Parasite Egg Count - veterinary ; Salicylanilides - administration & dosage ; Salicylanilides - pharmacology ; Salicylanilides - therapeutic use ; Sheep ; Sheep Diseases - drug therapy ; Sheep Diseases - epidemiology ; Thiophanate - administration & dosage ; Thiophanate - pharmacology ; Thiophanate - therapeutic use]]></subject><ispartof>Veterinary research communications, 1997-10, Vol.21 (7), p.483-491</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c252t-26cd20bae9137b15bab3e9ecb52b4a6b6b85dddd3a60244489720166954aed423</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9345715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Waruiru, R M</creatorcontrib><creatorcontrib>Ngotho, J W</creatorcontrib><creatorcontrib>Mukiri, J G</creatorcontrib><title>Multiple anthelmintic resistance in Haemonchus contortus on a sheep farm in Kenya</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><description>Multiple resistance to albendazole, thiophanate, levamisole and orally administered invermectin was detected in an isolate of Haemonchus contortus in sheep on a farm where benzimidazole resistance had already been identified. Following a faecal egg count reduction test, this was confirmed by both critical and controlled anthelmintic tests. Different groups of sheep infected naturally or given an experimental infection with the benzimidazole-resistant isolate were treated with the recommended doses of various anthelmintics. Compared to the control group, the percentage reductions in the faecal egg counts of sheep treated with albendazole, thiophanate, levamisole and ivermectin varied between 38.2% and 79.1% and the residual worm counts between 27.3% and 57.5%. The results indicate the presence of multiple anthelmintic resistance in this isolate of H. contortus. Sheep treated with closantel showed 100% reductions in faecal egg and worm counts, indicating that this drug was very effective against the population of H. contortus on the farm.</description><subject>Administration, Oral</subject><subject>Albendazole - administration & dosage</subject><subject>Albendazole - pharmacology</subject><subject>Albendazole - therapeutic use</subject><subject>Animals</subject><subject>Anthelmintics - administration & dosage</subject><subject>Anthelmintics - pharmacology</subject><subject>Anthelmintics - therapeutic use</subject><subject>Benzimidazoles - administration & dosage</subject><subject>Benzimidazoles - pharmacology</subject><subject>Benzimidazoles - therapeutic use</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Resistance, Multiple</subject><subject>Feces - parasitology</subject><subject>Haemonchiasis - drug therapy</subject><subject>Haemonchiasis - epidemiology</subject><subject>Haemonchiasis - veterinary</subject><subject>Haemonchus - drug effects</subject><subject>Haemonchus - isolation & purification</subject><subject>Ivermectin - administration & dosage</subject><subject>Ivermectin - pharmacology</subject><subject>Ivermectin - therapeutic use</subject><subject>Kenya - epidemiology</subject><subject>Levamisole - administration & dosage</subject><subject>Levamisole - pharmacology</subject><subject>Levamisole - therapeutic use</subject><subject>Parasite Egg Count - veterinary</subject><subject>Salicylanilides - administration & dosage</subject><subject>Salicylanilides - pharmacology</subject><subject>Salicylanilides - therapeutic use</subject><subject>Sheep</subject><subject>Sheep Diseases - drug therapy</subject><subject>Sheep Diseases - epidemiology</subject><subject>Thiophanate - administration & dosage</subject><subject>Thiophanate - pharmacology</subject><subject>Thiophanate - therapeutic use</subject><issn>0165-7380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkD1PwzAYhD2ASinMTEie2AL-TsxWVUARRQgJ5ui181Y1SpwQOwP_niB6y93w6KQ7Qq44u-VMyLv1PWdMW8skk1qLE7Jk3OiilBU7I-cpfTHGbMXkgiysVLrkekneX6c2h6FFCjEfsO1CzMHTEVNIGaJHGiLdAnZ99IcpUd_H3I95Tn2kQNMBcaB7GLs_7gXjD1yQ0z20CS-PviKfjw8fm22xe3t63qx3hRda5EIY3wjmAC2XpePagZNo0TstnALjjKt0M0uCYUIpVdlSzHOM1QqwUUKuyM1_7zD23xOmXHcheWxbiNhPqS6tNEJbPYPXR3ByHTb1MIYOxp_6-IH8BanJXGs</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Waruiru, R M</creator><creator>Ngotho, J W</creator><creator>Mukiri, J G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19971001</creationdate><title>Multiple anthelmintic resistance in Haemonchus contortus on a sheep farm in Kenya</title><author>Waruiru, R M ; Ngotho, J W ; Mukiri, J G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c252t-26cd20bae9137b15bab3e9ecb52b4a6b6b85dddd3a60244489720166954aed423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Administration, Oral</topic><topic>Albendazole - administration & dosage</topic><topic>Albendazole - pharmacology</topic><topic>Albendazole - therapeutic use</topic><topic>Animals</topic><topic>Anthelmintics - administration & dosage</topic><topic>Anthelmintics - pharmacology</topic><topic>Anthelmintics - therapeutic use</topic><topic>Benzimidazoles - administration & dosage</topic><topic>Benzimidazoles - pharmacology</topic><topic>Benzimidazoles - therapeutic use</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Resistance, Multiple</topic><topic>Feces - parasitology</topic><topic>Haemonchiasis - drug therapy</topic><topic>Haemonchiasis - epidemiology</topic><topic>Haemonchiasis - veterinary</topic><topic>Haemonchus - drug effects</topic><topic>Haemonchus - isolation & purification</topic><topic>Ivermectin - administration & dosage</topic><topic>Ivermectin - pharmacology</topic><topic>Ivermectin - therapeutic use</topic><topic>Kenya - epidemiology</topic><topic>Levamisole - administration & dosage</topic><topic>Levamisole - pharmacology</topic><topic>Levamisole - therapeutic use</topic><topic>Parasite Egg Count - veterinary</topic><topic>Salicylanilides - administration & dosage</topic><topic>Salicylanilides - pharmacology</topic><topic>Salicylanilides - therapeutic use</topic><topic>Sheep</topic><topic>Sheep Diseases - drug therapy</topic><topic>Sheep Diseases - epidemiology</topic><topic>Thiophanate - administration & dosage</topic><topic>Thiophanate - pharmacology</topic><topic>Thiophanate - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Waruiru, R M</creatorcontrib><creatorcontrib>Ngotho, J W</creatorcontrib><creatorcontrib>Mukiri, J G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waruiru, R M</au><au>Ngotho, J W</au><au>Mukiri, J G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple anthelmintic resistance in Haemonchus contortus on a sheep farm in Kenya</atitle><jtitle>Veterinary research communications</jtitle><addtitle>Vet Res Commun</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>21</volume><issue>7</issue><spage>483</spage><epage>491</epage><pages>483-491</pages><issn>0165-7380</issn><abstract>Multiple resistance to albendazole, thiophanate, levamisole and orally administered invermectin was detected in an isolate of Haemonchus contortus in sheep on a farm where benzimidazole resistance had already been identified. Following a faecal egg count reduction test, this was confirmed by both critical and controlled anthelmintic tests. Different groups of sheep infected naturally or given an experimental infection with the benzimidazole-resistant isolate were treated with the recommended doses of various anthelmintics. Compared to the control group, the percentage reductions in the faecal egg counts of sheep treated with albendazole, thiophanate, levamisole and ivermectin varied between 38.2% and 79.1% and the residual worm counts between 27.3% and 57.5%. The results indicate the presence of multiple anthelmintic resistance in this isolate of H. contortus. Sheep treated with closantel showed 100% reductions in faecal egg and worm counts, indicating that this drug was very effective against the population of H. contortus on the farm.</abstract><cop>Netherlands</cop><pmid>9345715</pmid><doi>10.1023/A:1005990303552</doi><tpages>9</tpages></addata></record> |
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| ispartof | Veterinary research communications, 1997-10, Vol.21 (7), p.483-491 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Administration, Oral Albendazole - administration & dosage Albendazole - pharmacology Albendazole - therapeutic use Animals Anthelmintics - administration & dosage Anthelmintics - pharmacology Anthelmintics - therapeutic use Benzimidazoles - administration & dosage Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Dose-Response Relationship, Drug Drug Resistance, Multiple Feces - parasitology Haemonchiasis - drug therapy Haemonchiasis - epidemiology Haemonchiasis - veterinary Haemonchus - drug effects Haemonchus - isolation & purification Ivermectin - administration & dosage Ivermectin - pharmacology Ivermectin - therapeutic use Kenya - epidemiology Levamisole - administration & dosage Levamisole - pharmacology Levamisole - therapeutic use Parasite Egg Count - veterinary Salicylanilides - administration & dosage Salicylanilides - pharmacology Salicylanilides - therapeutic use Sheep Sheep Diseases - drug therapy Sheep Diseases - epidemiology Thiophanate - administration & dosage Thiophanate - pharmacology Thiophanate - therapeutic use |
| title | Multiple anthelmintic resistance in Haemonchus contortus on a sheep farm in Kenya |
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