Normal Platelets and Megakaryocytes Are Produced In Vivo in the Absence of Thrombopoietin

Thrombopoietin (TPO) has been established as the major regulator of megakaryocyte and platelet production. In vitro and in vivo studies have demonstrated that TPO affects both megakaryocyte proliferation and maturation. In vitro, TPO has been reported to be essential for full development of megakary...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 1997-11, Vol.90 (9), p.3423-3429
Hauptverfasser:	Bunting, Stuart, Widmer, Ramon, Lipari, Terry, Rangell, Linda, Steinmetz, Hope, Carver-Moore, Karen, Moore, Mark W., Keller, Gilbert-Andre, de Sauvage, Frederic J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Platelets - cytology Blood Platelets - physiology Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell physiology Fundamental and applied biological sciences. Psychology Megakaryocytes - cytology Megakaryocytes - physiology Mice Mice, Knockout Microscopy, Electron Molecular and cellular biology Neoplasm Proteins Platelet Count Proto-Oncogene Proteins - deficiency Receptors, Cytokine Receptors, Thrombopoietin Thrombopoietin - deficiency
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!