Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice

The hormone leptin acts on the brain to regulate feeding, metabolism, and reproduction; however, its cellular targets and molecular mechanisms of action remain to be fully elucidated. The melanocortins, which are derived from the precursor proopiomelanocortin (POMC), are also implicated in the physi...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1997-11, Vol.138 (11), p.5063-5066
Hauptverfasser:	Thornton, J E, Cheung, C C, Clifton, D K, Steiner, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Count Eating - drug effects Hypothalamus - metabolism Hypothalamus - pathology Leptin Male Mice Mice, Mutant Strains - genetics Neurons - metabolism Neurons - pathology Obesity - genetics Obesity - metabolism Obesity - pathology Pro-Opiomelanocortin - genetics Proteins - genetics Proteins - metabolism Proteins - pharmacology RNA, Messenger - metabolism
Online-Zugang:	Volltext
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