Purinergic modulation in the flounder gut
1. Spontaneous mechanical responses of ileum and rectum of the flounder were recorded isometrically. 2. Both ileal and rectal segments showed positive dose-dependent inotropic but not chronotropic responses to ATP. 3. The P2 receptor antagonist α-β-M-ATP induced contractures in flounder ileum and re...
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| Veröffentlicht in: | General pharmacology 1989, Vol.20 (6), p.849-853 |
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| creator | Lennard, Roger Huddart, Henry |
| description | 1. Spontaneous mechanical responses of ileum and rectum of the flounder were recorded isometrically.
2. Both ileal and rectal segments showed positive dose-dependent inotropic but not chronotropic responses to ATP.
3. The P2 receptor antagonist α-β-M-ATP induced contractures in flounder ileum and rectum. Pretreatment with this agent blocked the responses of both ileum and rectum to ATP.
4. Adenosine abolished rhythmic activity and lowered basal tonus in the ileum but in the rectum adenosine induced dose-dependent positive inotropic responses.
5. Theophylline pretreatment abolished the positive inotropic effects of adenosine in the rectum and it prevented the inhibitory actions of adenosine in the ileum.
6. It is concluded that the positive actions of ATP in ileum and rectum are mediated via P2 purinoreceptors. The positive response of the rectum and inhibition of the ileum seen with adenosine appear to be mediated via mixed populations of excitatory and inhibitory P1 purinoreceptors. |
| doi_str_mv | 10.1016/0306-3623(89)90342-X |
| format | Article |
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2. Both ileal and rectal segments showed positive dose-dependent inotropic but not chronotropic responses to ATP.
3. The P2 receptor antagonist α-β-M-ATP induced contractures in flounder ileum and rectum. Pretreatment with this agent blocked the responses of both ileum and rectum to ATP.
4. Adenosine abolished rhythmic activity and lowered basal tonus in the ileum but in the rectum adenosine induced dose-dependent positive inotropic responses.
5. Theophylline pretreatment abolished the positive inotropic effects of adenosine in the rectum and it prevented the inhibitory actions of adenosine in the ileum.
6. It is concluded that the positive actions of ATP in ileum and rectum are mediated via P2 purinoreceptors. The positive response of the rectum and inhibition of the ileum seen with adenosine appear to be mediated via mixed populations of excitatory and inhibitory P1 purinoreceptors.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/0306-3623(89)90342-X</identifier><identifier>PMID: 2591713</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adenosine Triphosphate - pharmacology ; Animals ; ATP ; Digestive System Physiological Phenomena ; Female ; fish physiology ; Flatfishes - physiology ; Flounder - physiology ; gut ; Humans ; Ileum - drug effects ; Male ; Marine ; Muscle Contraction - drug effects ; Muscle, Smooth - physiology ; muscles ; neurotransmitters ; Platichthys flesus ; purines ; receptors ; Receptors, Purinergic - physiology ; Rectum - drug effects ; Xanthines - pharmacology</subject><ispartof>General pharmacology, 1989, Vol.20 (6), p.849-853</ispartof><rights>1989</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-1be01df0e6cd6f4d0080d26100c5829bede4d402aa374dbf34906b5e21d0b40f3</citedby><cites>FETCH-LOGICAL-c388t-1be01df0e6cd6f4d0080d26100c5829bede4d402aa374dbf34906b5e21d0b40f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2591713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lennard, Roger</creatorcontrib><creatorcontrib>Huddart, Henry</creatorcontrib><title>Purinergic modulation in the flounder gut</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1. Spontaneous mechanical responses of ileum and rectum of the flounder were recorded isometrically.
2. Both ileal and rectal segments showed positive dose-dependent inotropic but not chronotropic responses to ATP.
3. The P2 receptor antagonist α-β-M-ATP induced contractures in flounder ileum and rectum. Pretreatment with this agent blocked the responses of both ileum and rectum to ATP.
4. Adenosine abolished rhythmic activity and lowered basal tonus in the ileum but in the rectum adenosine induced dose-dependent positive inotropic responses.
5. Theophylline pretreatment abolished the positive inotropic effects of adenosine in the rectum and it prevented the inhibitory actions of adenosine in the ileum.
6. It is concluded that the positive actions of ATP in ileum and rectum are mediated via P2 purinoreceptors. The positive response of the rectum and inhibition of the ileum seen with adenosine appear to be mediated via mixed populations of excitatory and inhibitory P1 purinoreceptors.</description><subject>Adenosine Triphosphate - pharmacology</subject><subject>Animals</subject><subject>ATP</subject><subject>Digestive System Physiological Phenomena</subject><subject>Female</subject><subject>fish physiology</subject><subject>Flatfishes - physiology</subject><subject>Flounder - physiology</subject><subject>gut</subject><subject>Humans</subject><subject>Ileum - drug effects</subject><subject>Male</subject><subject>Marine</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - physiology</subject><subject>muscles</subject><subject>neurotransmitters</subject><subject>Platichthys flesus</subject><subject>purines</subject><subject>receptors</subject><subject>Receptors, Purinergic - physiology</subject><subject>Rectum - drug effects</subject><subject>Xanthines - pharmacology</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AUhQdRaq3-A4WsxC6idx6ZZDZCKb6goAuF7oZk5qaO5FFnEsF_b2pLl7q6i_Odc-Ej5JzCNQUqb4CDjLlk_CpTUwVcsHh5QMY0S1UMQOkhGe-RY3ISwgcAsISxERmxRNGU8jGZvvTeNehXzkR1a_sq71zbRK6JuneMyqrtG4s-WvXdKTkq8yrg2e5OyNv93ev8MV48PzzNZ4vY8CzrYlogUFsCSmNlKSxABpZJCmCSjKkCLQorgOU5T4UtSi4UyCJBRi0UAko-IZfb3bVvP3sMna5dMFhVeYNtH3SquASp5L8gTWQiQagBFFvQ-DYEj6Vee1fn_ltT0BuVeuNJbzzpTOlflXo51C52-31Ro92Xdu6G_Hab42Djy6HXwThsDFrn0XTatu7vBz-SsYGN</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Lennard, Roger</creator><creator>Huddart, Henry</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Purinergic modulation in the flounder gut</title><author>Lennard, Roger ; Huddart, Henry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-1be01df0e6cd6f4d0080d26100c5829bede4d402aa374dbf34906b5e21d0b40f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adenosine Triphosphate - pharmacology</topic><topic>Animals</topic><topic>ATP</topic><topic>Digestive System Physiological Phenomena</topic><topic>Female</topic><topic>fish physiology</topic><topic>Flatfishes - physiology</topic><topic>Flounder - physiology</topic><topic>gut</topic><topic>Humans</topic><topic>Ileum - drug effects</topic><topic>Male</topic><topic>Marine</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>muscles</topic><topic>neurotransmitters</topic><topic>Platichthys flesus</topic><topic>purines</topic><topic>receptors</topic><topic>Receptors, Purinergic - physiology</topic><topic>Rectum - drug effects</topic><topic>Xanthines - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Lennard, Roger</creatorcontrib><creatorcontrib>Huddart, Henry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lennard, Roger</au><au>Huddart, Henry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Purinergic modulation in the flounder gut</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1989</date><risdate>1989</risdate><volume>20</volume><issue>6</issue><spage>849</spage><epage>853</epage><pages>849-853</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><abstract>1. Spontaneous mechanical responses of ileum and rectum of the flounder were recorded isometrically.
2. Both ileal and rectal segments showed positive dose-dependent inotropic but not chronotropic responses to ATP.
3. The P2 receptor antagonist α-β-M-ATP induced contractures in flounder ileum and rectum. Pretreatment with this agent blocked the responses of both ileum and rectum to ATP.
4. Adenosine abolished rhythmic activity and lowered basal tonus in the ileum but in the rectum adenosine induced dose-dependent positive inotropic responses.
5. Theophylline pretreatment abolished the positive inotropic effects of adenosine in the rectum and it prevented the inhibitory actions of adenosine in the ileum.
6. It is concluded that the positive actions of ATP in ileum and rectum are mediated via P2 purinoreceptors. The positive response of the rectum and inhibition of the ileum seen with adenosine appear to be mediated via mixed populations of excitatory and inhibitory P1 purinoreceptors.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>2591713</pmid><doi>10.1016/0306-3623(89)90342-X</doi><tpages>5</tpages></addata></record> |
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| ispartof | General pharmacology, 1989, Vol.20 (6), p.849-853 |
| issn | 0306-3623 1879-0011 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenosine Triphosphate - pharmacology Animals ATP Digestive System Physiological Phenomena Female fish physiology Flatfishes - physiology Flounder - physiology gut Humans Ileum - drug effects Male Marine Muscle Contraction - drug effects Muscle, Smooth - physiology muscles neurotransmitters Platichthys flesus purines receptors Receptors, Purinergic - physiology Rectum - drug effects Xanthines - pharmacology |
| title | Purinergic modulation in the flounder gut |
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