A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

In S. cerevisiae, the G1/S transition requires Cdc4p, Cdc34p, Cdc53p, Skp1p, and the Cln/Cdc28p cyclin-dependent kinase (Cdk). These proteins are thought to promote the proteolytic inactivation of the S-phase Cdk inhibitor Sic1p. We show here that Cdc4p, Cdc53p, and Skp1p assemble into a ubiquitin l...

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Veröffentlicht in:	Cell 1997-10, Vol.91 (2), p.221-230
Hauptverfasser:	Feldman, R.M.Renny, Correll, Craig C, Kaplan, Kenneth B, Deshaies, Raymond J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - genetics Cell Cycle Proteins - isolation & purification Cell Cycle Proteins - metabolism Cullin Proteins Cyclin-Dependent Kinase Inhibitor Proteins Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - metabolism F-Box Proteins Fungal Proteins - isolation & purification Fungal Proteins - metabolism Insecta Phosphorylation Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Recombinant Proteins - metabolism S-Phase Kinase-Associated Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Ubiquitin-Protein Ligases Ubiquitins - metabolism
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