OPC-6535, a Superoxide Anion Production Inhibitor, Attenuates Acute Lung Injury

A large body of evidence has demonstrated that inhibition of the neutrophil's oxidant burst attenuates sepsis-induced acute lung injury. The present study sought to evaluate the ability of OPC-6535, a superoxide anion production inhibitor, to attenuate sepsis-induced acute lung injury. Four gro...

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Veröffentlicht in:	The Journal of surgical research 1997-09, Vol.72 (1), p.70-77
Hauptverfasser:	Bloomfield, Geoffrey L., Ridings, Philip C., Blocher, Charles R., Fisher, Bernard J., Sugerman, Harvey J., Nagamoto, Hisashi, Fowler, Alpha A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Anions - metabolism Biological and medical sciences Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Cell Cycle Disease Models, Animal Endothelium - enzymology Endothelium - immunology Hemodynamics Integrins - analysis Leukocyte Count Lung Diseases - drug therapy Lung Diseases - etiology Lung Diseases - metabolism Medical sciences Neutrophil Activation - immunology Neutrophils - chemistry Neutrophils - cytology Neutrophils - immunology Oxygen - blood Peroxidase - analysis Pharmacology. Drug treatments Pulmonary Circulation Respiratory Burst - immunology Respiratory system Sepsis - complications Sepsis - immunology Sepsis - metabolism Superoxides - metabolism Swine Thiazoles - pharmacology
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