Evidence that C4b-binding protein is an acute phase protein
C4b-binding protein is a regulatory factor for both complement and coagulation systems. We found that a human hepatoma cell line, Hep G2, was capable of synthesizing C4b-binding protein and that the secretion of C4b-binding protein was enhanced by interleukin-6 and tumor necrosis factor, which are k...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1989-11, Vol.164 (3), p.1446-1451 |
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| container_issue | 3 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Saeki, Toshihiko Hirose, Sakae Nukatsuka, Mamoru Kusunoki, Yukihiro Nagasawa, Shigeharu |
| description | C4b-binding protein is a regulatory factor for both complement and coagulation systems. We found that a human hepatoma cell line, Hep G2, was capable of synthesizing C4b-binding protein and that the secretion of C4b-binding protein was enhanced by interleukin-6 and tumor necrosis factor, which are known to be modulators of acute phase proteins. In addition, the plasma content of C4b-binding protein was found to increase in patients of acute pneumonia. These results suggest that C4b-binding protein is an acute phase protein. |
| doi_str_mv | 10.1016/0006-291X(89)91832-9 |
| format | Article |
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We found that a human hepatoma cell line, Hep G2, was capable of synthesizing C4b-binding protein and that the secretion of C4b-binding protein was enhanced by interleukin-6 and tumor necrosis factor, which are known to be modulators of acute phase proteins. In addition, the plasma content of C4b-binding protein was found to increase in patients of acute pneumonia. These results suggest that C4b-binding protein is an acute phase protein.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(89)91832-9</identifier><identifier>PMID: 2480119</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>acute phase substances ; Acute-Phase Proteins - biosynthesis ; Adult ; Analytical, structural and metabolic biochemistry ; Binding and carrier proteins ; Biological and medical sciences ; Carcinoma, Hepatocellular ; Carrier Proteins - biosynthesis ; Cell Line ; Child ; Complement C4b - metabolism ; Complement Inactivator Proteins ; Fundamental and applied biological sciences. Psychology ; Glycoproteins ; Humans ; interleukin 6 ; Interleukin-1 - pharmacology ; Kinetics ; Liver Neoplasms ; man ; Pneumonia - blood ; Proteins ; Recombinant Proteins - pharmacology ; Reference Values ; Tumor Cells, Cultured - drug effects ; Tumor Cells, Cultured - metabolism ; tumor necrosis factor ; Tumor Necrosis Factor-alpha - pharmacology</subject><ispartof>Biochemical and biophysical research communications, 1989-11, Vol.164 (3), p.1446-1451</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-9e80476c7e4f043ebc40f07dd16fbd5a032ba9389669b1a47963764efaa30b283</citedby><cites>FETCH-LOGICAL-c468t-9e80476c7e4f043ebc40f07dd16fbd5a032ba9389669b1a47963764efaa30b283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006291X89918329$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6671824$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2480119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saeki, Toshihiko</creatorcontrib><creatorcontrib>Hirose, Sakae</creatorcontrib><creatorcontrib>Nukatsuka, Mamoru</creatorcontrib><creatorcontrib>Kusunoki, Yukihiro</creatorcontrib><creatorcontrib>Nagasawa, Shigeharu</creatorcontrib><title>Evidence that C4b-binding protein is an acute phase protein</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>C4b-binding protein is a regulatory factor for both complement and coagulation systems. We found that a human hepatoma cell line, Hep G2, was capable of synthesizing C4b-binding protein and that the secretion of C4b-binding protein was enhanced by interleukin-6 and tumor necrosis factor, which are known to be modulators of acute phase proteins. In addition, the plasma content of C4b-binding protein was found to increase in patients of acute pneumonia. 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| ispartof | Biochemical and biophysical research communications, 1989-11, Vol.164 (3), p.1446-1451 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | acute phase substances Acute-Phase Proteins - biosynthesis Adult Analytical, structural and metabolic biochemistry Binding and carrier proteins Biological and medical sciences Carcinoma, Hepatocellular Carrier Proteins - biosynthesis Cell Line Child Complement C4b - metabolism Complement Inactivator Proteins Fundamental and applied biological sciences. Psychology Glycoproteins Humans interleukin 6 Interleukin-1 - pharmacology Kinetics Liver Neoplasms man Pneumonia - blood Proteins Recombinant Proteins - pharmacology Reference Values Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism tumor necrosis factor Tumor Necrosis Factor-alpha - pharmacology |
| title | Evidence that C4b-binding protein is an acute phase protein |
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