Activation of the phosphorothionate insecticide parathion by rat brain in situ
The ability of the rat brain to activate the phosphorothionate insecticide parathion to its potent anticholinesterase metabolite paraoxon in situ was observed by ligating the posterior portion of the circulatory system and thus removing the liver from the circulation. Under these conditions no acety...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1989-11, Vol.165 (1), p.327-333 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Chambers, J.E. (Mississippi State University, Mississippi State, MS) Munson, J.R Chambers, H.W |
| description | The ability of the rat brain to activate the phosphorothionate insecticide parathion to its potent anticholinesterase metabolite paraoxon in situ was observed by ligating the posterior portion of the circulatory system and thus removing the liver from the circulation. Under these conditions no acetylcholinesterase inhibition was observed in 15 min at a dosage of parathion (nominally 2.4 mg/kg) which yielded 95% inhibition when the liver was in the circulation. However, at a higher dose (nominally 48 mg/kg) there was substantial (about 70%) inhibition of brain acetylcholinesterase after 15 min, suggesting that the brain does have the ability to activate parathion in the intact situation. |
| doi_str_mv | 10.1016/0006-291X(89)91073-5 |
| format | Article |
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However, at a higher dose (nominally 48 mg/kg) there was substantial (about 70%) inhibition of brain acetylcholinesterase after 15 min, suggesting that the brain does have the ability to activate parathion in the intact situation.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(89)91073-5</identifier><identifier>PMID: 2590230</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier</publisher><subject>ACETILCOLINESTERASA ; ACETYLCHOLINESTERASE ; Acetylcholinesterase - metabolism ; Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Biotransformation ; BRAIN ; Brain - drug effects ; Brain - metabolism ; Carboxylesterase ; Carboxylic Ester Hydrolases - metabolism ; CEREBRO ; ENCEPHALE ; Enzymes and enzyme inhibitors ; Fundamental and applied biological sciences. 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However, at a higher dose (nominally 48 mg/kg) there was substantial (about 70%) inhibition of brain acetylcholinesterase after 15 min, suggesting that the brain does have the ability to activate parathion in the intact situation.</description><subject>ACETILCOLINESTERASA</subject><subject>ACETYLCHOLINESTERASE</subject><subject>Acetylcholinesterase - metabolism</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biotransformation</subject><subject>BRAIN</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Carboxylesterase</subject><subject>Carboxylic Ester Hydrolases - metabolism</subject><subject>CEREBRO</subject><subject>ENCEPHALE</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydrolases</subject><subject>INSECTICIDAS</subject><subject>INSECTICIDE</subject><subject>INSECTICIDES</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Parathion - metabolism</subject><subject>Parathion - pharmacology</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Inbred Strains</subject><subject>Reference Values</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M9LwzAUB_AgypzTf0AUchDRQ_UlaZvkOIa_YOhBB95K0iYu0rUzaYX994at7OohvJDvh8d7QeiCwB0Bkt8DQJ5QST5vhLyVBDhLsgM0JiAhoQTSQzTek2N0EsI3ACFpLkdoRDMJlMEYvU7Lzv2qzrUNbi3ulgavl22Ix7fdMr6qzmDXBBNZ6aqYKq-2AdYbHK9Ye-WaSHBwXX-Kjqyqgzkb6gQtHh8-Zs_J_O3pZTadJ5YCdElluVGSC86YBhkHzEFxagi1qbSiNEZpk6ZWigwyLawVlUy5yaQuNTNgJJug613ftW9_ehO6YuVCaepaNabtQ8Ely3LJxL-QZCkThJIILwfY65WpirV3K-U3xfBTMb8achVKVVuvmtKFPct53GHLznfMqrZQXz6SxbsEIkSesT9dBIDB</recordid><startdate>19891130</startdate><enddate>19891130</enddate><creator>Chambers, J.E. 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Psychology</topic><topic>Hydrolases</topic><topic>INSECTICIDAS</topic><topic>INSECTICIDE</topic><topic>INSECTICIDES</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Parathion - metabolism</topic><topic>Parathion - pharmacology</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Inbred Strains</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chambers, J.E. (Mississippi State University, Mississippi State, MS)</creatorcontrib><creatorcontrib>Munson, J.R</creatorcontrib><creatorcontrib>Chambers, H.W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chambers, J.E. (Mississippi State University, Mississippi State, MS)</au><au>Munson, J.R</au><au>Chambers, H.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of the phosphorothionate insecticide parathion by rat brain in situ</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1989-11-30</date><risdate>1989</risdate><volume>165</volume><issue>1</issue><spage>327</spage><epage>333</epage><pages>327-333</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>The ability of the rat brain to activate the phosphorothionate insecticide parathion to its potent anticholinesterase metabolite paraoxon in situ was observed by ligating the posterior portion of the circulatory system and thus removing the liver from the circulation. Under these conditions no acetylcholinesterase inhibition was observed in 15 min at a dosage of parathion (nominally 2.4 mg/kg) which yielded 95% inhibition when the liver was in the circulation. However, at a higher dose (nominally 48 mg/kg) there was substantial (about 70%) inhibition of brain acetylcholinesterase after 15 min, suggesting that the brain does have the ability to activate parathion in the intact situation.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>2590230</pmid><doi>10.1016/0006-291X(89)91073-5</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1989-11, Vol.165 (1), p.327-333 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ACETILCOLINESTERASA ACETYLCHOLINESTERASE Acetylcholinesterase - metabolism Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Biotransformation BRAIN Brain - drug effects Brain - metabolism Carboxylesterase Carboxylic Ester Hydrolases - metabolism CEREBRO ENCEPHALE Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases INSECTICIDAS INSECTICIDE INSECTICIDES Liver - drug effects Liver - enzymology Male Parathion - metabolism Parathion - pharmacology RAT RATA RATS Rats, Inbred Strains Reference Values |
| title | Activation of the phosphorothionate insecticide parathion by rat brain in situ |
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