A gastrin-releasing peptide antagonist containing a ψ(CH 2O) amide bond surrogate

The [Leu 26-ψ(CH 2O)Leu 27] derivative of N-Ac-GRP20–27-peptide amide was prepared and evaluated as a gastrin-releasing peptide antagonist. This ψ(CH 2O) derivative was found to be a more potent inhibitor of [ 3H-Phe 15]GRP15–27NH 2 binding and N-Ac-GRP20–27NH 2 induced mitogenesis in Swiss 3T3 fibr...

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Veröffentlicht in:	Biochemical and biophysical research communications 1989-11, Vol.165 (1), p.114-117
Hauptverfasser:	Saari, Walfred S., Heimbrook, David C., Friedman, Arthur, Fisher, Thorsten W., Oliff, Allen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Division - drug effects Cells, Cultured Fundamental and applied biological sciences. Psychology Gastrin-Releasing Peptide Gastrointestinal Hormones - antagonists & inhibitors Mice Molecular Sequence Data Peptide Fragments - chemical synthesis Peptide Fragments - metabolism Peptide Fragments - pharmacology Peptides - antagonists & inhibitors Peptides - chemical synthesis Peptides - metabolism Peptides - pharmacology Proteins Radioligand Assay Structure-Activity Relationship
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