Expression of mouse CD43 in the B cell lineage of transgenic mice causes impaired immune responses to T‐independent antigens

CD43 (leukosialin), a sialylated glycoprotein expressed on the surface of most hematopoietic cells, has been implicated in cell adhesion and signaling. However, its precise physiological function remains unclear. We used mouse CD43 (mCD43)‐immunoglobulin enhancer‐transgenic (TG) mice to study the ro...

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Veröffentlicht in:	European journal of immunology 1997-09, Vol.27 (9), p.2152-2159
Hauptverfasser:	Ostberg, Julie R., Dragone, Leonard L., Borrello, Melinda A., Phipps, Richard P., Barth, Richard K., Frelinger, John G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Antigens, CD Antigens, T-Independent - immunology B cell B-Lymphocytes - immunology CD43 Enhancer Elements, Genetic Ficoll - immunology Genes, Immunoglobulin Immunodeficiency Leukosialin Lipopolysaccharides - immunology Lymphocyte Activation Lymphocyte Cooperation Mice Mice, Transgenic Peritoneal Cavity - cytology Sialoglycoproteins - physiology T‐independent antigen
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