Role of Curdlan Sulfate in the Binding of HIV-1 gp120 to CD4 Molecules and the Production of gp120-Mediated TNF-α

To clarify the mechanism by which curdlan sulfate (CRDS) inhibits human immunodeficiency virus (HIV)-1 infection, we examined its influence on the binding of gp120 to CD4 molecules on T cells and macrophages, as well as on the production of TNF-α by gp120-stimulated macrophages (which promotes HIV-1...

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Veröffentlicht in:	MICROBIOLOGY and IMMUNOLOGY 1997, Vol.41(9), pp.741-745
Hauptverfasser:	Takeda-Hirokawa, Nanako, Neoh, Lian-pin, Akimoto, Hiroaki, Kaneko, Hiroshi, Hishikawa, Takashi, Sekigawa, Iwao, Hashimoto, Hiroshi, Hirose, Shun-ichi, Murakami, Tsutomu, Yamamoto, Naoki, Mimura, Tohru, Kaneko, Yutaro
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents beta-Glucans Biological and medical sciences CD4 Antigens - metabolism Curdlan sulfate Depression, Chemical Gene Expression Regulation - drug effects Glucans - pharmacology HIV Envelope Protein gp120 - metabolism HIV-1 - drug effects HIV-1 - metabolism HIV-1 gp120 Humans Macrophages - metabolism Medical sciences Pharmacology. Drug treatments Protein Binding - drug effects T-Lymphocytes - metabolism TNF-α Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
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