THA disrupts mismatch negativity in Alzheimer disease

The present study investigates the effects of 25 or 50 mg tetrahydroaminoacridine (THA), a cholinesterase inhibitor, on auditory mismatch negativity (MMN) event-related response in 19 patients with Alzheimer disease (AD). MMN is produced by the deviant tones representing passive attention and automa...

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Veröffentlicht in:	Psychopharmacologia 1997-09, Vol.133 (2), p.203-206
Hauptverfasser:	RIEKKINEN, P. JR, PÄÄKKÖNEN, A, KARHU, J, PARTANEN, J, SOININEN, H, LAAKSO, M, RIEKKINEN, P. SR
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - physiopathology Alzheimer's disease Attention task Biological and medical sciences Brain - drug effects Brain - physiopathology Cholinesterase inhibitors Cholinesterase Inhibitors - pharmacology Double-Blind Method Drug toxicity and drugs side effects treatment Evoked Potentials, Auditory - drug effects Evoked Potentials, Auditory - physiology Female Humans Interstimulus interval Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Mismatch negativity Neurodegenerative diseases Nootropic Agents - pharmacology Pharmacology. Drug treatments Tacrine - pharmacology
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