An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion

Hematogenous metastasis requires the arrest and extravasation of blood-borne tumor cells, possibly involving direct adhesive interactions with vascular endothelium. Cytokine activation of cultured human endothelium increases adhesion of melanoma and carcinoma cell lines. An inducible 110-kD endothel...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1989-12, Vol.246 (4935), p.1303-1306
Hauptverfasser:	Rice, G. Edgar, Bevilacqua, Michael P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibodies, Monoclonal Antigens Biological and medical sciences Cancer Cancer invasiveness Cancer metastasis Cell adhesion Cell Adhesion - physiology Cell Adhesion Molecules - analysis Cell Adhesion Molecules - physiology Cell growth Cell interactions, adhesion Cell lines Cell receptors Colonic Neoplasms - pathology Complementary DNA Endothelial cells Endothelium Endothelium, Vascular - analysis Endothelium, Vascular - cytology Endothelium, Vascular - physiology Fundamental and applied biological sciences. Psychology Humans Melanoma Melanoma - pathology Melanoma, Experimental - pathology Metastasis Methods Molecular and cellular biology Molecular Weight Physiological aspects Protein research Proteins Tumor Cells, Cultured Tumors Vascular endothelium
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