Development of the hypothalamic 5-hydroxytryptamine system during ontogenesis in rats: Uptake and release of 5-hydroxytryptamine in vitro
The development of the hypothalamic 5-hydroxytryptamine system has been evaluated in vitro according to [ 3H]5-hydroxytryptamine uptake and release in fetuses (16–20th fetal day), neonates (9th postnatal day) and adults (45th day of life). At the 16th fetal day the hypothalamic Neural elements were...
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| Veröffentlicht in: | Neuroscience 1989, Vol.32 (1), p.127-131 |
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| creator | Ugrumov, M.V. Proshlyakova, E.V. Sapronova, A. |
| description | The development of the hypothalamic 5-hydroxytryptamine system has been evaluated
in vitro according to [
3H]5-hydroxytryptamine uptake and release in fetuses (16–20th fetal day), neonates (9th postnatal day) and adults (45th day of life). At the 16th fetal day the hypothalamic Neural elements were characterized by specific uptake of 5-hydroxytryptamine and its spontaneous release; the next day K
+-stimulated Ca
2+-dependent release appeared. By the 18th fetal day, the 5-hydroxytryptamine uptake doubled and was retained at this level both in older fetuses and in postnatal rats. The K
+-stimulated release of [
3H]5-hydroxytryptamine increased considerably during the perinatal period, reaching an adult level by the 9th postnatal day.
These data indicate the sprouting of 5-hydroxytryptamine fibers to the hypothalamus and the maturation of their membrane mechanisms for the bidirectional transport of 5-hydroxytryptamine early during ontogenesis—to a significant extent before the 18th fetal day. |
| doi_str_mv | 10.1016/0306-4522(89)90112-7 |
| format | Article |
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in vitro according to [
3H]5-hydroxytryptamine uptake and release in fetuses (16–20th fetal day), neonates (9th postnatal day) and adults (45th day of life). At the 16th fetal day the hypothalamic Neural elements were characterized by specific uptake of 5-hydroxytryptamine and its spontaneous release; the next day K
+-stimulated Ca
2+-dependent release appeared. By the 18th fetal day, the 5-hydroxytryptamine uptake doubled and was retained at this level both in older fetuses and in postnatal rats. The K
+-stimulated release of [
3H]5-hydroxytryptamine increased considerably during the perinatal period, reaching an adult level by the 9th postnatal day.
These data indicate the sprouting of 5-hydroxytryptamine fibers to the hypothalamus and the maturation of their membrane mechanisms for the bidirectional transport of 5-hydroxytryptamine early during ontogenesis—to a significant extent before the 18th fetal day.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/0306-4522(89)90112-7</identifier><identifier>PMID: 2586745</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aging - metabolism ; Animals ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Embryonic and Fetal Development ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Hypothalamus - embryology ; Hypothalamus - growth & development ; Hypothalamus - metabolism ; Rats ; Rats, Inbred Strains ; Serotonin - pharmacokinetics ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 1989, Vol.32 (1), p.127-131</ispartof><rights>1989 IBRO</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0306-4522(89)90112-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6672108$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2586745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ugrumov, M.V.</creatorcontrib><creatorcontrib>Proshlyakova, E.V.</creatorcontrib><creatorcontrib>Sapronova, A.</creatorcontrib><title>Development of the hypothalamic 5-hydroxytryptamine system during ontogenesis in rats: Uptake and release of 5-hydroxytryptamine in vitro</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>The development of the hypothalamic 5-hydroxytryptamine system has been evaluated
in vitro according to [
3H]5-hydroxytryptamine uptake and release in fetuses (16–20th fetal day), neonates (9th postnatal day) and adults (45th day of life). At the 16th fetal day the hypothalamic Neural elements were characterized by specific uptake of 5-hydroxytryptamine and its spontaneous release; the next day K
+-stimulated Ca
2+-dependent release appeared. By the 18th fetal day, the 5-hydroxytryptamine uptake doubled and was retained at this level both in older fetuses and in postnatal rats. The K
+-stimulated release of [
3H]5-hydroxytryptamine increased considerably during the perinatal period, reaching an adult level by the 9th postnatal day.
These data indicate the sprouting of 5-hydroxytryptamine fibers to the hypothalamus and the maturation of their membrane mechanisms for the bidirectional transport of 5-hydroxytryptamine early during ontogenesis—to a significant extent before the 18th fetal day.</description><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Embryonic and Fetal Development</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Hypothalamus - embryology</subject><subject>Hypothalamus - growth & development</subject><subject>Hypothalamus - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Serotonin - pharmacokinetics</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi1EVZbCG4DkA0JwCNjxv7gHJFSgIFXiQs-W15l0DYkdbO-qeQTeGoeueqrEXEaa-c03mvkQekHJO0qofE8YkQ0Xbfum0281obRt1CO0oZ1ijRKcP0abe-QJeprzT1JDcHaKTlvRScXFBv35BAcY4zxBKDgOuOwA75Y5lp0d7eQdFs1u6VO8XUpa5lJLAXBecoEJ9_vkww2OocQbCJB9xj7gZEs-x9eV_QXYhh4nGMFmWNUfEqsjB19SfIZOBjtmeH7MZ-j6y-cfF1-bq--X3y4-XjXQMlkaoYVzsoOtllIIBowPTjrFiVCi01vlBtsqbTvQgnHiuNQMSLd1nPW8t6xjZ-j1ne6c4u895GImnx2Mow0Q99kozeoQ_z9IBa8bW1nBl0dwv52gN3Pyk02LOT659l8d-zY7Ow7JBufzPSalailZ9324w6Bef_CQTHYegoPeJ3DF9NEbSszqvVmNNauxptPmn_dGsb_DpqIi</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Ugrumov, M.V.</creator><creator>Proshlyakova, E.V.</creator><creator>Sapronova, A.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Development of the hypothalamic 5-hydroxytryptamine system during ontogenesis in rats: Uptake and release of 5-hydroxytryptamine in vitro</title><author>Ugrumov, M.V. ; Proshlyakova, E.V. ; Sapronova, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e236t-595cc68eb966553e34fc6c74057589b7cfa279a8e95340c4693e08bc43d4da383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Embryonic and Fetal Development</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestational Age</topic><topic>Hypothalamus - embryology</topic><topic>Hypothalamus - growth & development</topic><topic>Hypothalamus - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Serotonin - pharmacokinetics</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ugrumov, M.V.</creatorcontrib><creatorcontrib>Proshlyakova, E.V.</creatorcontrib><creatorcontrib>Sapronova, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ugrumov, M.V.</au><au>Proshlyakova, E.V.</au><au>Sapronova, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of the hypothalamic 5-hydroxytryptamine system during ontogenesis in rats: Uptake and release of 5-hydroxytryptamine in vitro</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1989</date><risdate>1989</risdate><volume>32</volume><issue>1</issue><spage>127</spage><epage>131</epage><pages>127-131</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>The development of the hypothalamic 5-hydroxytryptamine system has been evaluated
in vitro according to [
3H]5-hydroxytryptamine uptake and release in fetuses (16–20th fetal day), neonates (9th postnatal day) and adults (45th day of life). At the 16th fetal day the hypothalamic Neural elements were characterized by specific uptake of 5-hydroxytryptamine and its spontaneous release; the next day K
+-stimulated Ca
2+-dependent release appeared. By the 18th fetal day, the 5-hydroxytryptamine uptake doubled and was retained at this level both in older fetuses and in postnatal rats. The K
+-stimulated release of [
3H]5-hydroxytryptamine increased considerably during the perinatal period, reaching an adult level by the 9th postnatal day.
These data indicate the sprouting of 5-hydroxytryptamine fibers to the hypothalamus and the maturation of their membrane mechanisms for the bidirectional transport of 5-hydroxytryptamine early during ontogenesis—to a significant extent before the 18th fetal day.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2586745</pmid><doi>10.1016/0306-4522(89)90112-7</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuroscience, 1989, Vol.32 (1), p.127-131 |
| issn | 0306-4522 1873-7544 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aging - metabolism Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Embryonic and Fetal Development Fundamental and applied biological sciences. Psychology Gestational Age Hypothalamus - embryology Hypothalamus - growth & development Hypothalamus - metabolism Rats Rats, Inbred Strains Serotonin - pharmacokinetics Vertebrates: nervous system and sense organs |
| title | Development of the hypothalamic 5-hydroxytryptamine system during ontogenesis in rats: Uptake and release of 5-hydroxytryptamine in vitro |
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