Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder
We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5‐HTR2c) and serotonin transporter (5‐HTT) genes. No significant associations were found in the total patient sample. However, when the individua...
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| Veröffentlicht in: | American journal of medical genetics 1997-09, Vol.74 (5), p.504-506 |
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| container_title | American journal of medical genetics |
| container_volume | 74 |
| creator | Oruc˘, L. Verheyen, G.R. Furac˘, I. Jakovljević, M. Ivezić, S. Raeymaekers, P. Broeckhoven, C. Van |
| description | We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5‐HTR2c) and serotonin transporter (5‐HTT) genes. No significant associations were found in the total patient sample. However, when the individuals were divided according to gender, trends for association with both polymorphisms (P = 0.051 for 5‐HTR2c and P = 0.049 for 5‐HTT) in female patients were observed. These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women. Am. J. Med. Genet. 74:504–506, 1997. © 1997 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-8628(19970919)74:5<504::AID-AJMG10>3.0.CO;2-G |
| format | Article |
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Genet. 74:504–506, 1997. © 1997 Wiley‐Liss, Inc.</description><identifier>ISSN: 0148-7299</identifier><identifier>EISSN: 1096-8628</identifier><identifier>DOI: 10.1002/(SICI)1096-8628(19970919)74:5<504::AID-AJMG10>3.0.CO;2-G</identifier><identifier>PMID: 9342201</identifier><identifier>CODEN: AJMGDA</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Adult and adolescent clinical studies ; Aged ; association ; Biological and medical sciences ; Bipolar Disorder - genetics ; Bipolar disorders ; Carrier Proteins - genetics ; Female ; genetics ; Humans ; Male ; Medical sciences ; Membrane Glycoproteins - genetics ; Membrane Transport Proteins ; Middle Aged ; Mood disorders ; Nerve Tissue Proteins ; Polymorphism, Restriction Fragment Length ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Receptor, Serotonin, 5-HT2C ; Receptors, Serotonin - genetics ; Serotonin - genetics ; Serotonin - metabolism ; Serotonin Plasma Membrane Transport Proteins ; serotonin receptor 2c gene ; serotonin transporter gene</subject><ispartof>American journal of medical genetics, 1997-09, Vol.74 (5), p.504-506</ispartof><rights>Copyright © 1997 Wiley‐Liss, Inc.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5030-bee404ba43363c6f1760c08ad4b6ba5784e9726bb95c25555ca4c4883c1c2d343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2854623$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9342201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oruc˘, L.</creatorcontrib><creatorcontrib>Verheyen, G.R.</creatorcontrib><creatorcontrib>Furac˘, I.</creatorcontrib><creatorcontrib>Jakovljević, M.</creatorcontrib><creatorcontrib>Ivezić, S.</creatorcontrib><creatorcontrib>Raeymaekers, P.</creatorcontrib><creatorcontrib>Broeckhoven, C. Van</creatorcontrib><title>Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder</title><title>American journal of medical genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5‐HTR2c) and serotonin transporter (5‐HTT) genes. No significant associations were found in the total patient sample. However, when the individuals were divided according to gender, trends for association with both polymorphisms (P = 0.051 for 5‐HTR2c and P = 0.049 for 5‐HTT) in female patients were observed. These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women. Am. J. Med. Genet. 74:504–506, 1997. © 1997 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>association</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - genetics</subject><subject>Bipolar disorders</subject><subject>Carrier Proteins - genetics</subject><subject>Female</subject><subject>genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Transport Proteins</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Nerve Tissue Proteins</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Receptor, Serotonin, 5-HT2C</subject><subject>Receptors, Serotonin - genetics</subject><subject>Serotonin - genetics</subject><subject>Serotonin - metabolism</subject><subject>Serotonin Plasma Membrane Transport Proteins</subject><subject>serotonin receptor 2c gene</subject><subject>serotonin transporter gene</subject><issn>0148-7299</issn><issn>1096-8628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9v0zAcxS0EGt3gT0DKAaHtkOKfcVIQWhcg6zTogaGhXb5yHAcMaRLsVND_HpeEXkDCF0vvPT89fxA6J3hOMKbPTz-s8tUZwVkSpwlNT0mWSZyR7EzyhXgpMF8slqvX8fLqXUHwKzbH83z9gsbFPTQ7PLqPZpjwNJY0yx6iY--_YkyCQI_QUcY4pZjM0N3S-05bNdiujVSrmp23PurqaPhiIhFf3tA8ckabfuhc8KvfWjQ41fq-c4Nx0WfTGh_ZNipt3zXKRZX1nauMe4Qe1Krx5vF0n6CPb9_c5Jfx9bpY5cvrWAvMcFwawzEvFWcsYTqpiUywxqmqeJmUSsiUm0zSpCwzoakIRyuueZoyTTStGGcn6NnY27vu-9b4ATbWa9M0qjXd1oMMn00YS0Pw0xjUrvPemRp6ZzfK7YBg2GMH2GOHPUHYE4Q_2EFyEBCwAwTsMGIHBhjyNVAoQvWTacO23JjqUDxxDv7TyVdeq6YO_LT1hxhNBU8oC7G7MfbDNmb317z_rvvnuEkJ5fFYbv1gfh7KlfsGiWRSwO37Am4viLi4yhlI9gsS4bjB</recordid><startdate>19970919</startdate><enddate>19970919</enddate><creator>Oruc˘, L.</creator><creator>Verheyen, G.R.</creator><creator>Furac˘, I.</creator><creator>Jakovljević, M.</creator><creator>Ivezić, S.</creator><creator>Raeymaekers, P.</creator><creator>Broeckhoven, C. Van</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970919</creationdate><title>Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder</title><author>Oruc˘, L. ; Verheyen, G.R. ; Furac˘, I. ; Jakovljević, M. ; Ivezić, S. ; Raeymaekers, P. ; Broeckhoven, C. Van</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5030-bee404ba43363c6f1760c08ad4b6ba5784e9726bb95c25555ca4c4883c1c2d343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>association</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - genetics</topic><topic>Bipolar disorders</topic><topic>Carrier Proteins - genetics</topic><topic>Female</topic><topic>genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Transport Proteins</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Nerve Tissue Proteins</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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Genet</addtitle><date>1997-09-19</date><risdate>1997</risdate><volume>74</volume><issue>5</issue><spage>504</spage><epage>506</epage><pages>504-506</pages><issn>0148-7299</issn><eissn>1096-8628</eissn><coden>AJMGDA</coden><abstract>We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5‐HTR2c) and serotonin transporter (5‐HTT) genes. No significant associations were found in the total patient sample. However, when the individuals were divided according to gender, trends for association with both polymorphisms (P = 0.051 for 5‐HTR2c and P = 0.049 for 5‐HTT) in female patients were observed. These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women. Am. J. Med. 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| ispartof | American journal of medical genetics, 1997-09, Vol.74 (5), p.504-506 |
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| subjects | Adult Adult and adolescent clinical studies Aged association Biological and medical sciences Bipolar Disorder - genetics Bipolar disorders Carrier Proteins - genetics Female genetics Humans Male Medical sciences Membrane Glycoproteins - genetics Membrane Transport Proteins Middle Aged Mood disorders Nerve Tissue Proteins Polymorphism, Restriction Fragment Length Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptor, Serotonin, 5-HT2C Receptors, Serotonin - genetics Serotonin - genetics Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins serotonin receptor 2c gene serotonin transporter gene |
| title | Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder |
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