Respiratory muscle reserve in rats during heavy exercise
Luc E. Gosselin, David Megirian, Joshua Rodman, Donna Mueller, and Gaspar A. Farkas Department of Physical Therapy, Exercise, and Nutrition Sciences, State University of New York at Buffalo, Buffalo, New York 14214 Received 10 April 1997; accepted in final form 23 July 1997. Gosselin, Luc E., David...
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| creator | Gosselin, Luc E Megirian, David Rodman, Joshua Mueller, Donna Farkas, Gaspar A |
| description | Luc E.
Gosselin,
David
Megirian,
Joshua
Rodman,
Donna
Mueller, and
Gaspar A.
Farkas
Department of Physical Therapy, Exercise, and Nutrition
Sciences, State University of New York at Buffalo, Buffalo, New
York 14214
Received 10 April 1997; accepted in final form 23 July 1997.
Gosselin, Luc E., David Megirian, Joshua Rodman, Donna
Mueller, and Gaspar A. Farkas. Respiratory muscle reserve in rats
during heavy exercise. J. Appl.
Physiol. 83(4): 1405-1409, 1997. The extent to
which the respiratory pump muscles limit maximal aerobic capacity in
quadrupeds is not entirely clear. To examine the effect of reduced
respiratory muscle reserve on aerobic capacity, whole body
peak oxygen consumption
( O 2 peak ) was
measured in healthy Sprague-Dawley rats before and after Sham,
unilateral, or bilateral hemidiaphragm denervation (Dnv) surgery.
O 2 peak was
determined by using a graded treadmill running test.
Hemidiaphragm paralysis was verified after testing by
recording the absence of electromyographic activity during
inspiration. Before surgery, O 2 peak averaged 86, 87, and 92 ml · kg 1 · min 1
for the Sham, unilateral, and bilateral Dnv groups, respectively. Two
weeks after surgery, there was no significant change in
O 2 peak for
either the Sham or unilateral Dnv group. However,
O 2 peak decreased
~19% in the bilateral Dnv group 2 wk after surgery. These findings
strongly suggest that the pulmonary system in rats is designed such
that during heavy exercise, the remaining respiratory pump muscles are
able to compensate for the loss of one hemidiaphragm, but not of both.
hemiparalysis; diaphragm; denervation; peak oxygen consumption
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society |
| doi_str_mv | 10.1152/jappl.1997.83.4.1405 |
| format | Article |
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Gosselin,
David
Megirian,
Joshua
Rodman,
Donna
Mueller, and
Gaspar A.
Farkas
Department of Physical Therapy, Exercise, and Nutrition
Sciences, State University of New York at Buffalo, Buffalo, New
York 14214
Received 10 April 1997; accepted in final form 23 July 1997.
Gosselin, Luc E., David Megirian, Joshua Rodman, Donna
Mueller, and Gaspar A. Farkas. Respiratory muscle reserve in rats
during heavy exercise. J. Appl.
Physiol. 83(4): 1405-1409, 1997. The extent to
which the respiratory pump muscles limit maximal aerobic capacity in
quadrupeds is not entirely clear. To examine the effect of reduced
respiratory muscle reserve on aerobic capacity, whole body
peak oxygen consumption
( O 2 peak ) was
measured in healthy Sprague-Dawley rats before and after Sham,
unilateral, or bilateral hemidiaphragm denervation (Dnv) surgery.
O 2 peak was
determined by using a graded treadmill running test.
Hemidiaphragm paralysis was verified after testing by
recording the absence of electromyographic activity during
inspiration. Before surgery, O 2 peak averaged 86, 87, and 92 ml · kg 1 · min 1
for the Sham, unilateral, and bilateral Dnv groups, respectively. Two
weeks after surgery, there was no significant change in
O 2 peak for
either the Sham or unilateral Dnv group. However,
O 2 peak decreased
~19% in the bilateral Dnv group 2 wk after surgery. These findings
strongly suggest that the pulmonary system in rats is designed such
that during heavy exercise, the remaining respiratory pump muscles are
able to compensate for the loss of one hemidiaphragm, but not of both.
hemiparalysis; diaphragm; denervation; peak oxygen consumption
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1997.83.4.1405</identifier><identifier>PMID: 9338452</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Air breathing ; Animals ; Biological and medical sciences ; Body Weight - physiology ; Denervation ; Diaphragm - physiology ; Electromyography ; Fundamental and applied biological sciences. Psychology ; Male ; Oxygen Consumption - physiology ; Physical Exertion - physiology ; Rats ; Rats, Sprague-Dawley ; Respiratory Muscles - physiology ; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics ; Vertebrates: respiratory system</subject><ispartof>Journal of applied physiology (1985), 1997-10, Vol.83 (4), p.1405-1409</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-be2a59812cfff5259a465fde8ab7c49c83250ee3c41b4ac6391821b77dd8f6253</citedby><cites>FETCH-LOGICAL-c409t-be2a59812cfff5259a465fde8ab7c49c83250ee3c41b4ac6391821b77dd8f6253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2842924$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9338452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gosselin, Luc E</creatorcontrib><creatorcontrib>Megirian, David</creatorcontrib><creatorcontrib>Rodman, Joshua</creatorcontrib><creatorcontrib>Mueller, Donna</creatorcontrib><creatorcontrib>Farkas, Gaspar A</creatorcontrib><title>Respiratory muscle reserve in rats during heavy exercise</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Luc E.
Gosselin,
David
Megirian,
Joshua
Rodman,
Donna
Mueller, and
Gaspar A.
Farkas
Department of Physical Therapy, Exercise, and Nutrition
Sciences, State University of New York at Buffalo, Buffalo, New
York 14214
Received 10 April 1997; accepted in final form 23 July 1997.
Gosselin, Luc E., David Megirian, Joshua Rodman, Donna
Mueller, and Gaspar A. Farkas. Respiratory muscle reserve in rats
during heavy exercise. J. Appl.
Physiol. 83(4): 1405-1409, 1997. The extent to
which the respiratory pump muscles limit maximal aerobic capacity in
quadrupeds is not entirely clear. To examine the effect of reduced
respiratory muscle reserve on aerobic capacity, whole body
peak oxygen consumption
( O 2 peak ) was
measured in healthy Sprague-Dawley rats before and after Sham,
unilateral, or bilateral hemidiaphragm denervation (Dnv) surgery.
O 2 peak was
determined by using a graded treadmill running test.
Hemidiaphragm paralysis was verified after testing by
recording the absence of electromyographic activity during
inspiration. Before surgery, O 2 peak averaged 86, 87, and 92 ml · kg 1 · min 1
for the Sham, unilateral, and bilateral Dnv groups, respectively. Two
weeks after surgery, there was no significant change in
O 2 peak for
either the Sham or unilateral Dnv group. However,
O 2 peak decreased
~19% in the bilateral Dnv group 2 wk after surgery. These findings
strongly suggest that the pulmonary system in rats is designed such
that during heavy exercise, the remaining respiratory pump muscles are
able to compensate for the loss of one hemidiaphragm, but not of both.
hemiparalysis; diaphragm; denervation; peak oxygen consumption
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><subject>Air breathing</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - physiology</subject><subject>Denervation</subject><subject>Diaphragm - physiology</subject><subject>Electromyography</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Oxygen Consumption - physiology</subject><subject>Physical Exertion - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Respiratory Muscles - physiology</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Vertebrates: respiratory system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPGzEQxy1UlIbHN6DSHirUyy5-xvYRoaZUQkJCcLa83nFi5GQXO5tmvz0biCIuPc3h_5iZH0JXBFeECHrzarsuVkRrWSlW8YpwLE7QdJRoSWaYfENTJQUupVDyOzrL-RVjwrkgEzTRjCku6BSpJ8hdSHbTpqFY9dlFKBJkSFsowroYhVw0fQrrRbEEux0K2EFyIcMFOvU2Zrg8zHP0Mv_9fHdfPjz--Xt3-1A6jvWmrIFaoRWhznsvqNCWz4RvQNlaOq6dYlRgAOY4qbl1M6aJoqSWsmmUn1HBztH1Z2-X2rce8sasQnYQo11D22cjNeNcCj4a-afRpTbnBN50KaxsGgzBZg_MfAAze2BGMcPNHtgY-3Ho7-sVNMfQgdCo_zzoNjsbfbLr8f2jjSpONf2yfRkWy38hgemWQw5tbBeDmfcxPsNus7_guNl0jR9jv_4fG91fDn0HO4aWFQ</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Gosselin, Luc E</creator><creator>Megirian, David</creator><creator>Rodman, Joshua</creator><creator>Mueller, Donna</creator><creator>Farkas, Gaspar A</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971001</creationdate><title>Respiratory muscle reserve in rats during heavy exercise</title><author>Gosselin, Luc E ; Megirian, David ; Rodman, Joshua ; Mueller, Donna ; Farkas, Gaspar A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-be2a59812cfff5259a465fde8ab7c49c83250ee3c41b4ac6391821b77dd8f6253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Air breathing</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - physiology</topic><topic>Denervation</topic><topic>Diaphragm - physiology</topic><topic>Electromyography</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Oxygen Consumption - physiology</topic><topic>Physical Exertion - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Respiratory Muscles - physiology</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gosselin, Luc E</creatorcontrib><creatorcontrib>Megirian, David</creatorcontrib><creatorcontrib>Rodman, Joshua</creatorcontrib><creatorcontrib>Mueller, Donna</creatorcontrib><creatorcontrib>Farkas, Gaspar A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gosselin, Luc E</au><au>Megirian, David</au><au>Rodman, Joshua</au><au>Mueller, Donna</au><au>Farkas, Gaspar A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Respiratory muscle reserve in rats during heavy exercise</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>83</volume><issue>4</issue><spage>1405</spage><epage>1409</epage><pages>1405-1409</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Luc E.
Gosselin,
David
Megirian,
Joshua
Rodman,
Donna
Mueller, and
Gaspar A.
Farkas
Department of Physical Therapy, Exercise, and Nutrition
Sciences, State University of New York at Buffalo, Buffalo, New
York 14214
Received 10 April 1997; accepted in final form 23 July 1997.
Gosselin, Luc E., David Megirian, Joshua Rodman, Donna
Mueller, and Gaspar A. Farkas. Respiratory muscle reserve in rats
during heavy exercise. J. Appl.
Physiol. 83(4): 1405-1409, 1997. The extent to
which the respiratory pump muscles limit maximal aerobic capacity in
quadrupeds is not entirely clear. To examine the effect of reduced
respiratory muscle reserve on aerobic capacity, whole body
peak oxygen consumption
( O 2 peak ) was
measured in healthy Sprague-Dawley rats before and after Sham,
unilateral, or bilateral hemidiaphragm denervation (Dnv) surgery.
O 2 peak was
determined by using a graded treadmill running test.
Hemidiaphragm paralysis was verified after testing by
recording the absence of electromyographic activity during
inspiration. Before surgery, O 2 peak averaged 86, 87, and 92 ml · kg 1 · min 1
for the Sham, unilateral, and bilateral Dnv groups, respectively. Two
weeks after surgery, there was no significant change in
O 2 peak for
either the Sham or unilateral Dnv group. However,
O 2 peak decreased
~19% in the bilateral Dnv group 2 wk after surgery. These findings
strongly suggest that the pulmonary system in rats is designed such
that during heavy exercise, the remaining respiratory pump muscles are
able to compensate for the loss of one hemidiaphragm, but not of both.
hemiparalysis; diaphragm; denervation; peak oxygen consumption
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>9338452</pmid><doi>10.1152/jappl.1997.83.4.1405</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 1997-10, Vol.83 (4), p.1405-1409 |
| issn | 8750-7587 1522-1601 |
| language | eng |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Air breathing Animals Biological and medical sciences Body Weight - physiology Denervation Diaphragm - physiology Electromyography Fundamental and applied biological sciences. Psychology Male Oxygen Consumption - physiology Physical Exertion - physiology Rats Rats, Sprague-Dawley Respiratory Muscles - physiology Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Vertebrates: respiratory system |
| title | Respiratory muscle reserve in rats during heavy exercise |
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