Relative substrate activities of structurally related pteridine, quinazoline, and pyrimidine analogs for mouse liver folylpolyglutamate synthetase

Several structurally related series of folate analogs were studied as substrates for mouse liver folylpolyglutamate synthetase (FPGS). A comparison of the kinetics of the interaction of this enzyme with folate analogs that contained the quinazoline ring in place of the pteridine ring with those of t...

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Veröffentlicht in:	Molecular pharmacology 1989-11, Vol.36 (5), p.736-743
Hauptverfasser:	MORAN, R. G, COLMAN, P. D, JONES, T. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Animals Antineoplastic agents Biological and medical sciences General aspects Kinetics liver Liver - enzymology Medical sciences Mice Peptide Synthases - antagonists & inhibitors Peptide Synthases - metabolism Pharmacology. Drug treatments Pteridines - metabolism Pyrimidines - metabolism Quinazolines - metabolism Structure-Activity Relationship Substrate Specificity
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