Attention-Deficit Hyperactivity Disorder With Bipolar Disorder: A Familial Subtype?

To clarify the nosological status of children with attention-deficit hyperactivity disorder (ADHD) who also satisfy diagnostic criteria for bipolar disorder (BPD). Blind raters and structured psychiatric interviews were used to examine 140 children with ADHD, a sample of 120 non-ADHD comparisons, an...

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Veröffentlicht in:Journal of the American Academy of Child and Adolescent Psychiatry 1997-10, Vol.36 (10), p.1378-1390
Hauptverfasser: FARAONE, STEPHEN V., BIEDERMAN, JOSEPH, MENNIN, DOUGLAS, WOZNIAK, JANET, SPENCER, THOMAS
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container_end_page 1390
container_issue 10
container_start_page 1378
container_title Journal of the American Academy of Child and Adolescent Psychiatry
container_volume 36
creator FARAONE, STEPHEN V.
BIEDERMAN, JOSEPH
MENNIN, DOUGLAS
WOZNIAK, JANET
SPENCER, THOMAS
description To clarify the nosological status of children with attention-deficit hyperactivity disorder (ADHD) who also satisfy diagnostic criteria for bipolar disorder (BPD). Blind raters and structured psychiatric interviews were used to examine 140 children with ADHD, a sample of 120 non-ADHD comparisons, and their 822 first-degree relatives. Data analyses tested specific hypotheses about the familial relationship between ADHD and BPD. After stratifying the ADHD sample into those with and without BPD, the authors found that (1) relatives of both ADHD subgroups were at significantly greater risk for ADHD than relatives of non-ADHD controls; (2) the two subgroups did not differ significantly from one another in their relatives' risk for ADHD; (3) a fivefold elevated risk for BPD was observed among relatives when the proband child had BPD but not when the proband had ADHD alone; (4) an elevated risk for major depression with severe impairment was found for relatives of ADHD+BPD probands; (5) both ADHD and BPD occurred in the same relatives more often than expected by chance alone; and (6) there was a trend for random mating between ADHD parents and those with mania. The data suggest that comorbid ADHD with BPD is famililally distinct from other forms of ADHD and may be related to what others have termed childhood-onset BPD.
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After stratifying the ADHD sample into those with and without BPD, the authors found that (1) relatives of both ADHD subgroups were at significantly greater risk for ADHD than relatives of non-ADHD controls; (2) the two subgroups did not differ significantly from one another in their relatives' risk for ADHD; (3) a fivefold elevated risk for BPD was observed among relatives when the proband child had BPD but not when the proband had ADHD alone; (4) an elevated risk for major depression with severe impairment was found for relatives of ADHD+BPD probands; (5) both ADHD and BPD occurred in the same relatives more often than expected by chance alone; and (6) there was a trend for random mating between ADHD parents and those with mania. 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source MEDLINE; Journals@Ovid Complete; Applied Social Sciences Index & Abstracts (ASSIA); Access via ScienceDirect (Elsevier)
subjects Adolescent
Adult
Attention Deficit Disorder with Hyperactivity - complications
Attention Deficit Disorder with Hyperactivity - genetics
Attention deficit hyperactivity disorder
bipolar disorder
Bipolar Disorder - complications
Bipolar Disorder - genetics
Child
Child psychology
comorbidity
Female
Genetics
Humans
Male
Manic depression
Middle Aged
nosology
title Attention-Deficit Hyperactivity Disorder With Bipolar Disorder: A Familial Subtype?
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