Bioactive human recombinant tumor necrosis factor‐α: an unstable dimer?

As determined by native polyacrylamide gel electrophoresis (PAGE) and gel chromatography the molecular mass of native tumor necrosis factor (TNF)‐α was approximately 35 kDa. When incubated at low concentrations (< 1 nM) 125I‐labeled TNF‐α and unlabeled TNF‐α rapidly multimerized or dissociated in...

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