Local but no systemic immunomodulation by intraperitoneal treatment of advanced ovarian cancer with autologous T lymphocytes re‐targeted by a bi‐specific monoclonal antibody

We have reported a 27% overall anti‐tumor response using i.p. immunotherapy of advanced ovarian carcinoma with autologous, ex vivo expanded, T lymphocytes re‐targeted with bi‐specific monoclonal antibody OC/TR, combined with soluble OC/TR and low‐dose recombinant interleukin‐2 (IL‐2). This treatment...

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Veröffentlicht in:	International journal of cancer 1997-10, Vol.73 (2), p.211-219
Hauptverfasser:	Lamers, Cor H.J., Bolhuis, Reinder L.H., Warnaar, Sven O., Stoter, Gerrit, Gratama, Jan W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bispecific - therapeutic use Antibodies, Monoclonal - therapeutic use Ascitic Fluid - cytology Biological and medical sciences CD3 Complex - immunology Cytotoxicity, Immunologic Female Flow Cytometry Genital system. Mammary gland Humans Immunophenotyping Immunotherapy Infusions, Parenteral Leukapheresis Lymphocyte Activation - immunology Lymphocyte Count Medical sciences Ovarian Neoplasms - immunology Ovarian Neoplasms - therapy Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology
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