Microchimerism and hyporesponsiveness induced by intraportal injection of donor spleen cells in rats

It is controversial whether or not microchimerism (MC) is responsible for the induction and maintenance of donor-specific tolerance. We have shown that intraportal injection (i.p.) of donor splenocytes induces a long-term graft survival of liver and heart in rats. In this study, we examined by polym...

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Veröffentlicht in:	Cell transplantation 1997-09, Vol.6 (5), p.551-552
Hauptverfasser:	Ota, Hirofumi, Gotoh, Mitsukazu, Ohzato, Hiroki, Dono, Keizo, Takeda, Yutaka, Umeshita, Koji, Sakon, Masato, Nishisho, Isamu, Monden, Morito
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Transplantation - physiology DNA - analysis Graft Survival - immunology Heart Transplantation - immunology Histocompatibility Antigens - genetics Intraportal injection Liver Male Microchimerism Polymerase Chain Reaction Rats Rats, Wistar Spleen - cytology Tolerance Transplantation Chimera - immunology Transplantation, Heterotopic
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